Search Results - "Duffin, Rodger"

A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis by Barth, Nicole D., Subiros-Funosas, Ramon, Mendive-Tapia, Lorena, Duffin, Rodger, Shields, Mario A., Cartwright, Jennifer A., Henriques, Sónia Troeira, Sot, Jesus, Goñi, Felix M., Lavilla, Rodolfo, Marwick, John A., Vermeren, Sonja, Rossi, Adriano G., Egeblad, Mikala, Dransfield, Ian, Vendrell, Marc

“…Programmed cell death or apoptosis is a central biological process that is dysregulated in many diseases, including inflammatory conditions and cancer. The…”
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Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma by Donaldson, Ken, Murphy, Fiona A, Duffin, Rodger, Poland, Craig A

“…The unique hazard posed to the pleural mesothelium by asbestos has engendered concern in potential for a similar risk from high aspect ratio nanoparticles…”
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Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes by Cho, Wan-Seob, Duffin, Rodger, Howie, Sarah E M, Scotton, Chris J, Wallace, William A H, Macnee, William, Bradley, Mark, Megson, Ian L, Donaldson, Ken

“…Large production volumes of zinc oxide nanoparticles (ZnONP) might be anticipated to pose risks, of accidental inhalation in occupational and even in consumer…”
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The Biologically Effective Dose in Inhalation Nanotoxicology by Donaldson, Ken, Schinwald, Anja, Murphy, Fiona, Cho, Wan-Seob, Duffin, Rodger, Tran, Lang, Poland, Craig

“…In all branches of toxicology, the biologically effective dose (BED) is thefraction of the total dose of a toxin that actually drives any toxic effect…”
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Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles by Cho, Wan-Seob, Duffin, Rodger, Thielbeer, Frank, Bradley, Mark, Megson, Ian L, Macnee, William, Poland, Craig A, Tran, C Lang, Donaldson, Ken

“…The toxicology of nanoparticles (NPs) is an area of intense investigation that would be greatly aided by improved understanding of the relationship between NP…”
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Proinflammogenic Effects of Low-Toxicity and Metal Nanoparticles In Vivo and In Vitro: Highlighting the Role of Particle Surface Area and Surface Reactivity by Duffin, Rodger, Tran, Lang, Brown, David, Stone, Vicki, Donaldson, Ken

“…Different particle types cause excessive lung inflammation that is thought to play a role in the various types of pathology they produce. Recently attention…”
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Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis by Gray, Robert D, Hardisty, Gareth, Regan, Kate H, Smith, Maeve, Robb, Calum T, Duffin, Rodger, Mackellar, Annie, Felton, Jennifer M, Paemka, Lily, McCullagh, Brian N, Lucas, Christopher D, Dorward, David A, McKone, Edward F, Cooke, Gordon, Donnelly, Seamas C, Singh, Pradeep K, Stoltz, David A, Haslett, Christopher, McCray, Paul B, Whyte, Moira K B, Rossi, Adriano G, Davidson, Donald J

“…Cystic fibrosis (CF) lung disease is defined by large numbers of neutrophils and associated damaging products in the airway. Delayed neutrophil apoptosis is…”
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Length-Dependent Retention of Carbon Nanotubes in the Pleural Space of Mice Initiates Sustained Inflammation and Progressive Fibrosis on the Parietal Pleura by Murphy, Fiona A, Poland, Craig A, Duffin, Rodger, Al-Jamal, Khuloud T, Ali-Boucetta, Hanene, Nunes, Antonio, Byrne, Fiona, Prina-Mello, Adriele, Volkov, Yuri, Li, Shouping, Mather, Stephen J, Bianco, Alberto, Prato, Maurizio, MacNee, William, Wallace, William A, Kostarelos, Kostas, Donaldson, Ken

“…The fibrous shape of carbon nanotubes (CNTs) raises concern that they may pose an asbestos-like inhalation hazard, leading to the development of diseases,…”
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Neutrophil Apoptosis: Relevance to the Innate Immune Response and Inflammatory Disease by Fox, Sarah, Leitch, Andrew E., Duffin, Rodger, Haslett, Christopher, Rossi, Adriano G.

“…Neutrophils are the most abundant cell type involved in the innate immune response. They are rapidly recruited to sites of injury or infection where they…”
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The impact of different nanoparticle surface chemistry and size on uptake and toxicity in a murine macrophage cell line by Clift, Martin J.D., Rothen-Rutishauser, Barbara, Brown, David M., Duffin, Rodger, Donaldson, Ken, Proudfoot, Lorna, Guy, Keith, Stone, Vicki

“…This study investigated the uptake, kinetics and cellular distribution of different surface coated quantum dots (QDs) before relating this to their toxicity…”
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Targeting granulocyte apoptosis: mechanisms, models, and therapies by Duffin, Rodger, Leitch, Andrew E, Fox, Sarah, Haslett, Chris, Rossi, Adriano G

“…The inflammatory process is a complex series of tightly controlled cellular and biochemical events initiated by the immune system, which has evolved to…”
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Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles by Cho, Wan-Seob, Duffin, Rodger, Bradley, Mark, Megson, Ian L, MacNee, William, Lee, Jong Kwon, Jeong, Jayoung, Donaldson, Ken

“…Hazard identification for risk assessment of nanoparticles (NPs) is mainly composed of in vitro cell-based assays and in vivo animal experimentation. The…”
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Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin by Bournazou, Irini, Pound, John D, Duffin, Rodger, Bournazos, Stylianos, Melville, Lynsey A, Brown, Simon B, Rossi, Adriano G, Gregory, Christopher D

“…Apoptosis is a noninflammatory, programmed form of cell death. One mechanism underlying the non-phlogistic nature of the apoptosis program is the swift…”
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Mer-mediated eosinophil efferocytosis regulates resolution of allergic airway inflammation by Felton, Jennifer M., Lucas, Christopher D., Dorward, David A., Duffin, Rodger, Kipari, Tiina, Vermeren, Sonja, Robb, Calum T., MacLeod, Kenneth G., Serrels, Bryan, Schwarze, Jürgen, Haslett, Christopher, Dransfield, Ian, Rossi, Adriano G.

“…Eosinophils play a central role in propagation of allergic diseases, including asthma. Both recruitment and retention of eosinophils regulate pulmonary…”
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Combustion-derived nanoparticles: a review of their toxicology following inhalation exposure by Donaldson, Ken, Tran, Lang, Jimenez, Luis Albert, Duffin, Rodger, Newby, David E, Mills, Nicholas, MacNee, William, Stone, Vicki

“…This review considers the molecular toxicology of combustion-derived nanoparticles (CDNP) following inhalation exposure. CDNP originate from a number of…”
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Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis by Rossi, Adriano G, Sawatzky, Deborah A, Walker, Annemieke, Ward, Carol, Sheldrake, Tara A, Riley, Nicola A, Caldicott, Alison, Martinez-Losa, Magdalena, Walker, Trevor R, Duffin, Rodger, Gray, Mohini, Crescenzi, Elvira, Martin, Morag C, Brady, Hugh J, Savill, John S, Dransfield, Ian, Haslett, Christopher

“…Apoptosis is essential for clearance of potentially injurious inflammatory cells and subsequent efficient resolution of inflammation. Here we report that human…”
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Protein corona formation in bronchoalveolar fluid enhances diesel exhaust nanoparticle uptake and pro-inflammatory responses in macrophages by Shaw, Catherine A., Mortimer, Gysell M., Deng, Zhou J., Carter, Edwin S., Connell, Shea P., Miller, Mark R., Duffin, Rodger, Newby, David E., Hadoke, Patrick W.F., Minchin, Rodney F.

“…In biological fluids nanoparticles bind a range of molecules, particularly proteins, on their surface. The resulting protein corona influences biological…”
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Inflammation as a Key Outcome Pathway in Particle Induced Effects in the Lung by Borm, Paul J A, Lison, Dominique, Driscoll, Kevin, Duffin, Rodger, Harkema, Jack, Weber, Klaus, Elder, Alison

“…Inflammation is considered a key event in the pathology of many chronic diseases, including pulmonary and systemic particle induced effects. In addition,…”
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Inhibition of eosinophil migration by lactoferrin by Bournazou, Irini, Mackenzie, Karen J, Duffin, Rodger, Rossi, Adriano G, Gregory, Christopher D

“…Eosinophilic granulocytes are innate effector cells that are important in immune responses against helminth parasitic infections and contribute towards the…”
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Formylated Peptide Receptor-1-Mediated Gut Inflammation as a Therapeutic Target in Inflammatory Bowel Disease by McAllister, Milly J, Hall, Rebecca, Whelan, Robert J, Fischer, Lena J, Chuah, Cher S, Cartlidge, Peter D, Drury, Broc, Rutherford, Duncan G, Duffin, Rodger M, Cartwright, Jennifer A, Dorward, David A, Rossi, Adriano G, Ho, Gwo-tzer

“…Abstract Background Formylated peptide receptor (FPR)-1 is a G-coupled receptor that senses foreign bacterial and host-derived mitochondrial formylated…”
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