Search Results - "Duerkop, Breck A."

Targeted IS-element sequencing uncovers transposition dynamics during selective pressure in enterococci by Kirsch, Joshua M, Ely, Shannon, Stellfox, Madison E, Hullahalli, Karthik, Luong, Phat, Palmer, Kelli L, Van Tyne, Daria, Duerkop, Breck A

“…Insertion sequences (IS) are simple transposons implicated in the genome evolution of diverse pathogenic bacterial species. Enterococci have emerged as…”
Get full text

Molecular mechanisms of enterococcal-bacteriophage interactions and implications for human health by Canfield, Gregory S, Duerkop, Breck A

“…•Phage-bacteria interactions drive key fitness tradeoffs in enterococci.•Discovery of novel phage receptors will aid in the future therapeutic development of…”
Get full text

Bacteriophages shift the focus of the mammalian microbiota by Duerkop, Breck A

“…[...]it has become increasingly clear that resident microbes are integral to health and disease. The use of gnotobiotic mice colonized with a defined bacterial…”
Get full text

Precision editing of the gut microbiota ameliorates colitis by Zhu, Wenhan, Winter, Maria G., Byndloss, Mariana X., Spiga, Luisella, Duerkop, Breck A., Hughes, Elizabeth R., Büttner, Lisa, de Lima Romão, Everton, Behrendt, Cassie L., Lopez, Christopher A., Sifuentes-Dominguez, Luis, Huff-Hardy, Kayci, Wilson, R. Paul, Gillis, Caroline C., Tükel, Çagla, Koh, Andrew Y., Burstein, Ezra, Hooper, Lora V., Bäumler, Andreas J., Winter, Sebastian E.

“…Tungstate inhibits molybdenum-cofactor-dependent microbial respiratory pathways and shows potential as a selective treatment for microbial imbalances that…”
Get full text

Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis by Hughes, Elizabeth R., Winter, Maria G., Duerkop, Breck A., Spiga, Luisella, Furtado de Carvalho, Tatiane, Zhu, Wenhan, Gillis, Caroline C., Büttner, Lisa, Smoot, Madeline P., Behrendt, Cassie L., Cherry, Sara, Santos, Renato L., Hooper, Lora V., Winter, Sebastian E.

“…Intestinal inflammation is frequently associated with an alteration of the gut microbiota, termed dysbiosis, which is characterized by a reduced abundance…”
Get full text

Phage infection and sub-lethal antibiotic exposure mediate Enterococcus faecalis type VII secretion system dependent inhibition of bystander bacteria by Chatterjee, Anushila, Willett, Julia L E, Dunny, Gary M, Duerkop, Breck A

“…Bacteriophages (phages) are being considered as alternative therapeutics for the treatment of multidrug resistant bacterial infections. Considering phages have…”
Get full text

Bacteriophage Resistance Alters Antibiotic-Mediated Intestinal Expansion of Enterococci by Chatterjee, Anushila, Johnson, Cydney N, Luong, Phat, Hullahalli, Karthik, McBride, Sara W, Schubert, Alyxandria M, Palmer, Kelli L, Carlson, Jr, Paul E, Duerkop, Breck A

“…is a human intestinal pathobiont with intrinsic and acquired resistance to many antibiotics, including vancomycin. Nature provides a diverse and virtually…”
Get full text

CRISPR-based antimicrobials to obstruct antibiotic-resistant and pathogenic bacteria by Palacios Araya, Dennise, Palmer, Kelli L, Duerkop, Breck A

“…Toward this goal, clustered regularly interspaced short palindromic repeats/CRISPR-associated protein (CRISPR/Cas) systems are being explored as possible…”
Get full text

Beyond Bacteria: Bacteriophage-Eukaryotic Host Interactions Reveal Emerging Paradigms of Health and Disease by Chatterjee, Anushila, Duerkop, Breck A

“…For decades, a wealth of information has been acquired to define how host associated microbial communities contribute to health and disease. Within the human…”
Get full text

composite bacteriophage alters colonization by an intestinal commensal bacterium by Duerkop, Breck A, Clements, Charmaine V, Rollins, Darcy, Rodrigues, Jorge L. M, Hooper, Lora V

“…The mammalian intestine is home to a dense community of bacteria and its associated bacteriophage (phage). Virtually nothing is known about how phages impact…”
Get full text

Pseudo-pac site sequences used by phage P22 in generalized transduction of Salmonella by Maier, Jessie L, Gin, Craig, Callahan, Benjamin, Sheriff, Emma K, Duerkop, Breck A, Kleiner, Manuel

“…Salmonella enterica Serovar Typhimurium (Salmonella) and its bacteriophage P22 are a model system for the study of horizontal gene transfer by generalized…”
Get full text

Molecular Basis for Lytic Bacteriophage Resistance in Enterococci by Duerkop, Breck A, Huo, Wenwen, Bhardwaj, Pooja, Palmer, Kelli L, Hooper, Lora V

“…The human intestine harbors diverse communities of bacteria and bacteriophages. Given the specificity of phages for their bacterial hosts, there is growing…”
Get full text

Parallel Genomics Uncover Novel Enterococcal-Bacteriophage Interactions by Chatterjee, Anushila, Willett, Julia L E, Nguyen, Uyen Thy, Monogue, Brendan, Palmer, Kelli L, Dunny, Gary M, Duerkop, Breck A

“…Bacteriophages (phages) have been proposed as alternative therapeutics for the treatment of multidrug-resistant bacterial infections. However, there are major…”
Get full text

An enterococcal phage protein inhibits type IV restriction enzymes involved in antiphage defense by Bullen, Nathan P., Johnson, Cydney N., Andersen, Shelby E., Arya, Garima, Marotta, Sonia R., Lee, Yan-Jiun, Weigele, Peter R., Whitney, John C., Duerkop, Breck A.

“…The prevalence of multidrug resistant (MDR) bacterial infections continues to rise as the development of antibiotics needed to combat these infections remains…”
Get full text

Transductomics: sequencing-based detection and analysis of transduced DNA in pure cultures and microbial communities by Kleiner, Manuel, Bushnell, Brian, Sanderson, Kenneth E, Hooper, Lora V, Duerkop, Breck A

“…Horizontal gene transfer (HGT) plays a central role in microbial evolution. Our understanding of the mechanisms, frequency, and taxonomic range of HGT in…”
Get full text

Bacteriophage and antibiotic combination therapy for recurrent Enterococcus faecium bacteremia by Stellfox, Madison E, Fernandes, Carolyn, Shields, Ryan K, Haidar, Ghady, Hughes Kramer, Kailey, Dembinski, Emily, Mangalea, Mihnea R, Arya, Garima, Canfield, Gregory S, Duerkop, Breck A, Van Tyne, Daria

“…is a member of the human gastrointestinal (GI) microbiota but can also cause invasive infections, especially in immunocompromised hosts. Enterococci display…”
Get full text

Aging-Associated Augmentation of Gut Microbiome Virulence Capability Drives Sepsis Severity by Colbert, James F, Kirsch, Joshua M, Erzen, Christopher L, Langouët-Astrié, Christophe J, Thompson, Grace E, McMurtry, Sarah A, Kofonow, Jennifer M, Robertson, Charles E, Kovacs, Elizabeth J, Sullivan, Ryan C, Hippensteel, Joseph A, Sawant, Namrata V, De Nisco, Nicole J, McCollister, Bruce D, Schwartz, Robert S, Horswill, Alexander R, Frank, Daniel N, Duerkop, Breck A, Schmidt, Eric P

“…Prior research has focused on host factors as mediators of exaggerated sepsis-associated morbidity and mortality in older adults. This focus on the host,…”
Get full text

Enterococcus faecalis CRISPR-Cas Is a Robust Barrier to Conjugative Antibiotic Resistance Dissemination in the Murine Intestine by Price, Valerie J, McBride, Sara W, Hullahalli, Karthik, Chatterjee, Anushila, Duerkop, Breck A, Palmer, Kelli L

“…CRISPR-Cas systems are barriers to horizontal gene transfer (HGT) in bacteria. Little is known about CRISPR-Cas interactions with conjugative plasmids, and…”
Get full text

Bacteriophage-Bacteria Interactions in the Gut: From Invertebrates to Mammals by Kirsch, Joshua M, Brzozowski, Robert S, Faith, Dominick, Round, June L, Secor, Patrick R, Duerkop, Breck A

“…Bacteria and their viruses (bacteriophages or phages) interact antagonistically and beneficially in polymicrobial communities such as the guts of animals…”
Get full text

Fitness Trade-Offs Resulting from Bacteriophage Resistance Potentiate Synergistic Antibacterial Strategies by Mangalea, Mihnea R, Duerkop, Breck A

“…Bacteria that cause life-threatening infections in humans are becoming increasingly difficult to treat. In some instances, this is due to intrinsic and…”
Get full text