Potassium Bromide for Treatment of Malignant Migrating Partial Seizures in Infancy

Abstract Background The syndrome of malignant migrating partial seizures in infancy is a rare epileptic syndrome with a devastating course characterized by early onset of continuous pharmacoresistent multifocal seizures arising from multiple independent sites of both hemispheres with unknown etiolog...

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Published in:	Pediatric neurology Vol. 49; no. 5; pp. 355 - 357
Main Authors:	Uenver, Olcay, Incecik, Faruk, Duendar, Huelya, Komuer, Mustafa, Uenver, Afsin, Okuyaz, Cetin
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-11-2013
Subjects:	Anticonvulsants - therapeutic use Bromides - therapeutic use Electroencephalography Epilepsies, Partial - drug therapy Humans Infant Male malignant migrating partial seizures in infancy Neurology Pediatrics potassium bromide Potassium Compounds - therapeutic use refractory epilepsy potassium bromide refractory epilepsy malignant migrating partial seizures in infancy
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Summary:	Abstract Background The syndrome of malignant migrating partial seizures in infancy is a rare epileptic syndrome with a devastating course characterized by early onset of continuous pharmacoresistent multifocal seizures arising from multiple independent sites of both hemispheres with unknown etiology. Patient A 2-month-old boy with the characteristic clinical and electroencephalograph pattern of migrating partial seizures in infancy was treated with potassium bromide. His seizures were unresponsive to the conventional and new generation antiepileptic drugs. Results The seizure frequency was reduced markedly with potassium bromide. Conclusions Potassium bromide, an old antiepileptic drug, is useful in the treatment of malignant migrating partial seizures in infancy.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0887-8994 1873-5150
DOI:	10.1016/j.pediatrneurol.2013.05.016