Search Results - "Duell, Elizabeth"

Topical N-Acetyl Cysteine and Genistein Prevent Ultraviolet-Light-Induced Signaling That Leads to Photoaging in Human Skin in vivo by Kang, Sewon, Chung, Jin Ho, Lee, Joo Heung, Fisher, Gary J., Wan, Yian Sheng, Duell, Elizabeth A., Voorhees, John J.

“…Human skin is exposed to solar ultraviolet radiation. Ultraviolet radiation damages human skin and results in an old and wrinkled appearance, called…”
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Application of Retinol to Human Skin In Vivo Induces Epidermal Hyperplasia and Cellular Retinoid Binding Proteins Characteristic of Retinoic Acid but Without Measurable Retinoic Acid Levels or Irritation by Kang, Sewon, Duell, Elizabeth A., Fisher, Gary J., Datta, Subhash C., Wang, Zeng-Quan, Reddy, Ambati P., Tavakkol, Amir, Yi, Jong Y., Griffiths, Christopher E.M., Elder, James T., Voorhees, John J.

“…We investigated the clinical, histologic, and molecular responses of normal human skin to all-trans-retinol (ROL) application, compared to those induced by…”
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Effect of Topical Cyclosporine Rinse on Oral Lichen Planus: A Double-Blind Analysis by Eisen, Drore, Ellis, Charles N, Duell, Elizabeth A, Griffiths, Christopher E.M, Voorhees, John J

“…Oral lichen planus is a relatively common disorder affecting up to 2 percent of the general population. 1 Any oral mucosal site may be involved, and there are…”
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Auto-regulation of Retinoic Acid Biosynthesis through Regulation of Retinol Esterification in Human Keratinocytes by Kurlandsky, S B, Duell, E A, Kang, S, Voorhees, J J, Fisher, G J

“…In this report, we describe an auto-regulatory loop in human keratinocytes, whereby all- trans retinoic acid (retinoic acid) regulates its own biosynthesis…”
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Cyclosporine Improves Psoriasis in a Double-blind Study by Ellis, Charles N, Gorsulowsky, David C, Hamilton, Ted A, Billings, Julie K, Brown, Marc D, Headington, John T, Cooper, Kevin D, Baadsgaard, Ole, Duell, Elizabeth A, Annesley, Thomas M, Turcotte, Jeremiah G, Voorhees, John J

“…In a double-blind trial, 21 patients with severe plaque psoriasis were randomly assigned to receive oral cyclosporine, 14 mg/kg/d, or its vehicle. After four…”
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Cellular, Immunologic and Biochemical Characterization of Topical Retinoic Acid—Treated Human Skin by Fisher, Gary J., Esmann, Jorgen, Grifliths, Christopher E.M., Talwar, Harvinder S., Duell, Elizabeth A., Hammerberg, Craig, Elder, James T., Karabin, Gerald D., Nickoloff, Brian J., Cooper, Kevin D., Voorhees, John J.

“…Histologic and clinical improvement of sun-exposed skin following topical treatment with retinoic acid has been reported. Daily application of retinoic acid…”
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In Vitro Model of Essential Fatty Acid Deficiency by Marcelo, Cynthia L, Duell, Elizabeth A, Rhodes, Lenore M, Dunham, William R

“…The polyunsaturated fatty acids linoleic acid (18:2, n-6) and arachidonic acid (20:4, n-6) are essential for normal skin function and structure, both as…”
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Levels of Cyclosporin in Epidermis of Treated Psoriasis Patients Differentially Inhibit Growth of Keratinocytes Cultured in Serum Free Versus Serum Containing Media by Fisher, Gary J., Duell, Elizabeth A., Nickoloff, Brian J., Annesley, Thomas M., Kowalke, Jennifer K., Ellis, Charles N., Voorhees, John J.

“…Cyclosporin A, which is a specific immunosuppressive compound, has recently been demonstrated to be of significant benefit in the treatment of psoriasis…”
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Mechanisms of Cyclosporine A Inhibition of Antigen-Presenting Activity in Uninvolved and Lesional Psoriatic Epidermis by Cooper, Kevin D., Baadsgaard, Ole, Ellis, Charles N., Duell, Elizabeth, Voorhees, John J.

“…To elucidate how cyclosporine A affects antigen-presenting cell subsets and their function in human skin, we studied patients with psoriasis undergoing a…”
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Determination of 5,12, and 15-Lipoxygenase Products in Keratomed Biopsies of Normal and Psoriatic Skin by Duell, Elizabeth A., Ellis, Charles N., Voorhees, John J.

“…Keratomed epidermal tissue from normal individuals and from the lesional and non-lesional skin of psoriasis patients served as source materials for the…”
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Retinoic acid antagonizes basal as well as coal tar and glucocorticoid-induced cytochrome P4501A1 expression in human skin by Li, X Y, Aström, A, Duell, E A, Qin, L, Griffiths, C E, Voorhees, J J

“…Cytochrome P4501A1 is known to be expressed in skin and thus has been implicated in the pathogenesis of skin cancer due to certain environmental carcinogens…”
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Unoccluded Retinol Penetrates Human Skin In Vivo More Effectively Than Unoccluded Retinyl Palmitate or Retinoic Acid by Duell, Elizabeth A., Kang, Sewon, Voorhess, John J.

“…The formation of all-trans retinoic acid is an oxidative process whereby retinol is converted to retinaldehyde and then to retinoic acid. Because retinol…”
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Arachidonic Acid Transformations in Normal and Psoriatic Skin by Hammarström, Sven, Lindgren, Jan Åke, Marcelo, Cynthia, Duell, Elizabeth A., Anderson, Thomas F., Voorhees, John J.

“…The levels of free arachidonic acid and 12L-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) are elevated in lesional epidermis of psoriasis (Hammarström et…”
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Extraction of Human Epidermis Treated with Retinol Yields Retro-Retinoids in Addition to Free Retinol and Retinyl Esters by Duell, Elizabeth A., Kang, Sewon, Elder, James T., Voorhees, John J., Derguini, Fadila

“…Vitamin A, all-trans-retinol, is metabolized to retinoic acid in vivo by a tightly controlled two-step conversion. Retinoic acid then binds to nuclear…”
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Cyclosporine for Plaque-Type Psoriasis: Results of a Multidose, Double-Blind Trial by Ellis, Charles N, Fradin, Mark S, Messana, Joseph M, Brown, Marc D, Siegel, Michael T, Hartley, A. Howland, Rocher, Leslie L, Wheeler, Suzanne, Hamilton, Ted A, Parish, Thomas G, Ellis-Madu, Mary, Duell, Elizabeth, Annesley, Thomas M, Cooper, Kevin D, Voorhees, John J

“…The effectiveness of cyclosporine in the treatment of psoriasis was a serendipitous finding by Mueller and Herrmann, 1 who included four patients with…”
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Biological activity of all-trans retinol requires metabolic conversion to all-trans retinoic acid and is mediated through activation of nuclear retinoid receptors in human keratinocytes by Kurlandsky, S B, Xiao, J H, Duell, E A, Voorhees, J J, Fisher, G J

“…The biological activity of all-trans retinol, in human keratinocytes, was investigated through metabolic and functional analyses that assessed the capacity for…”
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Retinoic Acid Receptors Regulate Expression of Retinoic Acid 4-Hydroxylase that Specifically Inactivates All-Trans Retinoic Acid in Human Keratinocyte HaCaT Cells by Marikar, Yasmin, Wang, ZengQuan, Petkovich, Martin, Voorhees, John J., Fisher, Gary J., Duell, Elizabeth A.

“…Tissue levels of all-trans retinoic acid (RA) are maintained through coordinated regulation of biosynthesis and breakdown. The major pathway for all-trans RA…”
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Sulfasalazine improves psoriasis. A double-blind analysis by Gupta, A K, Ellis, C N, Siegel, M T, Duell, E A, Griffiths, C E, Hamilton, T A, Nickoloff, B J, Voorhees, J J

“…In an 8-week double-blind trial of sulfasalazine for the treatment of moderate-to-severe psoriasis, 23 and 27 patients received the active and placebo tablets,…”
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The Retinoid X Receptor Agonist 9-cis-Retinoic Acid and the 24-Hydroxylase Inhibitor Ketoconazole Increase Activity of 1,25-Dihydroxyvitamin D3 in Human Skin In Vivo by Kang, Sewon, Li, Xiao-Yan, Duell, Elizabeth A., Voorhees, John J.

“…1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] transactivates its target genes via the vitamin D receptor (VDR). VDR functions in physiology as a dimer complexed with…”
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Retinoic Acid Isomers Applied to Human Skin in Vivo Each Induce a 4-Hydroxylase That Inactivates Only Trans Retinoic Acid by Duell, Elizabeth A., Kang, Sewon, Voorhees, John J.

“…Application of all-trans retinoic acid to human skin for 4 d under occlusion produces a marked increase in retinoic acid 4-hydroxylase activity. In this study,…”
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