Human parvovirus B19: a new emerging pathogen of inflammatory cardiomyopathy

The human parvovirus B19 (PVB19), an erythrovirus causing diverse clinical manifestations ranging from asymptomatic or mild to more severe outcomes such as hydrops fetalis, is the only known human pathogenic parvovirus so far. Although enteroviruses have long been considered the most common cause of...

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Bibliographic Details
Published in:	Journal of veterinary medicine. Series B Vol. 52; no. 7-8; pp. 340 - 343
Main Authors:	Bock, C.T, Klingel, K, Aberle, S, Duechting, A, Lupescu, A, Lang, F, Kandolf, R
Format:	Journal Article
Language:	English
Published:	Berlin, Germany Blackwell Verlag GmbH 01-09-2005 Blackwell Publishing Ltd
Subjects:	B19 virus cardiomyopathy Cardiomyopathy, Dilated - etiology Cardiomyopathy, Dilated - virology Cardiovascular disease Cells complications emerging diseases endothelial cells Erythrovirus etiology human diseases Human parvovirus B19 Humans inflammation Inflammatory diseases literature reviews Parvoviridae Infections - complications Parvovirus B19, Human - pathogenicity pathogenesis Pathogens viral diseases of animals and humans Viruses
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Summary:	The human parvovirus B19 (PVB19), an erythrovirus causing diverse clinical manifestations ranging from asymptomatic or mild to more severe outcomes such as hydrops fetalis, is the only known human pathogenic parvovirus so far. Although enteroviruses have long been considered the most common cause of inflammatory cardiomyopathy, PVB19 is emerging as a important candidate. Recent studies have indicated an association of PVB19 with paediatric and adult inflammatory cardiac disease. However, whether or not PVB19 has an impact on inflammatory cardiomyopathy in adult patients is still unclear. The first hints for a possible aetiopathogenetic role of the PVB19-infection and the development of cardiac dysfunction were demonstrated by molecular biology utilizing in situ hybridization (ISH) and polymerase chain reaction (PCR). According to available evidence, PVB19-associated inflammatory cardiomyopathy is characterized by infection of endothelial cells of small intracardiac arterioles and venules, which may be associated with endothelial dysfunction, impairment of myocardial microcirculation, and penetration of inflammatory cells into the myocardium.
Bibliography:	ArticleID:ZPH867 ark:/67375/WNG-R8D5HZCZ-H istex:086F9340D8CAE78E30485490A2CF4FFD2DC09F44 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0931-1793 1863-1959 1439-0450 1863-2378
DOI:	10.1111/j.1439-0450.2005.00867.x