Search Results - "Dudman, Joshua T."

The timing of action determines reward prediction signals in identified midbrain dopamine neurons by Coddington, Luke T., Dudman, Joshua T.

“…Animals adapt their behavior in response to informative sensory cues using multiple brain circuits. The activity of midbrain dopaminergic neurons is thought to…”
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Opponent and bidirectional control of movement velocity in the basal ganglia by Yttri, Eric A., Dudman, Joshua T.

“…Activity in the direct and indirect basal ganglia pathways can bidirectionally control the speed of movements that underlie reward-seeking actions in mice…”
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Learning from Action: Reconsidering Movement Signaling in Midbrain Dopamine Neuron Activity by Coddington, Luke T., Dudman, Joshua T.

“…Animals infer when and where a reward is available from experience with informative sensory stimuli and their own actions. In vertebrates, this is thought to…”
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The basal ganglia: from motor commands to the control of vigor by Dudman, Joshua T, Krakauer, John W

“…Highlights • Vertebrates are remarkable for their ability to select and execute motor skill. • Motor skill is defined by flexibility of execution while…”
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A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons by Tervo, D. Gowanlock R., Hwang, Bum-Yeol, Viswanathan, Sarada, Gaj, Thomas, Lavzin, Maria, Ritola, Kimberly D., Lindo, Sarah, Michael, Susan, Kuleshova, Elena, Ojala, David, Huang, Cheng-Chiu, Gerfen, Charles R., Schiller, Jackie, Dudman, Joshua T., Hantman, Adam W., Looger, Loren L., Schaffer, David V., Karpova, Alla Y.

“…Efficient retrograde access to projection neurons for the delivery of sensors and effectors constitutes an important and enabling capability for neural circuit…”
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Mesolimbic dopamine adapts the rate of learning from action by Coddington, Luke T., Lindo, Sarah E., Dudman, Joshua T.

“…Recent success in training artificial agents and robots derives from a combination of direct learning of behavioural policies and indirect learning through…”
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Dopamine Is Required for the Neural Representation and Control of Movement Vigor by Panigrahi, Babita, Martin, Kathleen A., Li, Yi, Graves, Austin R., Vollmer, Alison, Olson, Lars, Mensh, Brett D., Karpova, Alla Y., Dudman, Joshua T.

“…Progressive depletion of midbrain dopamine neurons (PDD) is associated with deficits in the initiation, speed, and fluidity of voluntary movement. Models…”
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Reconstruction of 1,000 Projection Neurons Reveals New Cell Types and Organization of Long-Range Connectivity in the Mouse Brain by Winnubst, Johan, Bas, Erhan, Ferreira, Tiago A., Wu, Zhuhao, Economo, Michael N., Edson, Patrick, Arthur, Ben J., Bruns, Christopher, Rokicki, Konrad, Schauder, David, Olbris, Donald J., Murphy, Sean D., Ackerman, David G., Arshadi, Cameron, Baldwin, Perry, Blake, Regina, Elsayed, Ahmad, Hasan, Mashtura, Ramirez, Daniel, Dos Santos, Bruno, Weldon, Monet, Zafar, Amina, Dudman, Joshua T., Gerfen, Charles R., Hantman, Adam W., Korff, Wyatt, Sternson, Scott M., Spruston, Nelson, Svoboda, Karel, Chandrashekar, Jayaram

“…Neuronal cell types are the nodes of neural circuits that determine the flow of information within the brain. Neuronal morphology, especially the shape of the…”
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A repeated molecular architecture across thalamic pathways by Phillips, James W., Schulmann, Anton, Hara, Erina, Winnubst, Johan, Liu, Chenghao, Valakh, Vera, Wang, Lihua, Shields, Brenda C., Korff, Wyatt, Chandrashekar, Jayaram, Lemire, Andrew L., Mensh, Brett, Dudman, Joshua T., Nelson, Sacha B., Hantman, Adam W.

“…The thalamus is the central communication hub of the forebrain and provides the cerebral cortex with inputs from sensory organs, subcortical systems and the…”
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Minimally invasive microendoscopy system for in vivo functional imaging of deep nuclei in the mouse brain by Bocarsly, Miriam E, Jiang, Wan-Chen, Wang, Chen, Dudman, Joshua T, Ji, Na, Aponte, Yeka

“…The ability to image neurons anywhere in the mammalian brain is a major goal of optical microscopy. Here we describe a minimally invasive microendoscopy system…”
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HCN1 channels constrain synaptically evoked Ca2+ spikes in distal dendrites of CA1 pyramidal neurons by Tsay, David, Dudman, Joshua T, Siegelbaum, Steven A

“…HCN1 hyperpolarization-activated cation channels act as an inhibitory constraint of both spatial learning and synaptic integration and long-term plasticity in…”
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A Role for Synaptic Inputs at Distal Dendrites: Instructive Signals for Hippocampal Long-Term Plasticity by Dudman, Joshua T., Tsay, David, Siegelbaum, Steven A.

“…Synaptic potentials originating at distal dendritic locations are severely attenuated when they reach the soma and, thus, are poor at driving somatic spikes…”
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Precise spatial coding is preserved along the longitudinal hippocampal axis by Keinath, Alexander T., Wang, Melissa E., Wann, Ellen G., Yuan, Robin K., Dudman, Joshua T., Muzzio, Isabel A.

“…ABSTRACT Compared with the dorsal hippocampus, relatively few studies have characterized neuronal responses in the ventral hippocampus. In particular, it is…”
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Desensitized D2 autoreceptors are resistant to trafficking by Robinson, Brooks G., Bunzow, James R., Grimm, Jonathan B., Lavis, Luke D., Dudman, Joshua T., Brown, Jennifer, Neve, Kim A., Williams, John T.

“…Dendritic release of dopamine activates dopamine D2 autoreceptors, which are inhibitory G protein-coupled receptors (GPCRs), to decrease the excitability of…”
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RIVETS: a mechanical system for in vivo and in vitro electrophysiology and imaging by Osborne, Jason E, Dudman, Joshua T

“…A number of recent studies have provided compelling demonstrations that both mice and rats can be trained to perform a variety of behavioral tasks while…”
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HCN1 Channels Control Resting and Active Integrative Properties of Stellate Cells from Layer II of the Entorhinal Cortex by Nolan, Matthew F, Dudman, Joshua T, Dodson, Paul D, Santoro, Bina

“…Whereas recent studies have elucidated principles for representation of information within the entorhinal cortex, less is known about the molecular basis for…”
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Individual Differences in Trait Anxiety Predict the Response of the Basolateral Amygdala to Unconsciously Processed Fearful Faces by Etkin, Amit, Klemenhagen, Kristen C., Dudman, Joshua T., Rogan, Michael T., Hen, René, Kandel, Eric R., Hirsch, Joy

“…Responses to threat-related stimuli are influenced by conscious and unconscious processes, but the neural systems underlying these processes and their…”
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Inputs to the dorsal striatum of the mouse reflect the parallel circuit architecture of the forebrain by Pan, Weixing X, Mao, Tianyi, Dudman, Joshua T

“…The basal ganglia play a critical role in the regulation of voluntary action in vertebrates. Our understanding of the function of the basal ganglia relies…”
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Mechanism of Positive Allosteric Modulators Acting on AMPA Receptors by Jin, Rongsheng, Clark, Suzanne, Weeks, Autumn M, Dudman, Joshua T, Gouaux, Eric, Partin, Kathryn M

“…Ligand-gated ion channels involved in the modulation of synaptic strength are the AMPA, kainate, and NMDA glutamate receptors. Small molecules that potentiate…”
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The Hyperpolarization-Activated HCN1 Channel Is Important for Motor Learning and Neuronal Integration by Cerebellar Purkinje Cells by Nolan, Matthew F., Malleret, Gaël, Lee, Ka Hung, Gibbs, Emma, Dudman, Joshua T., Santoro, Bina, Yin, Deqi, Thompson, Richard F., Siegelbaum, Steven A., Kandel, Eric R., Morozov, Alexei

“…In contrast to our increasingly detailed understanding of how synaptic plasticity provides a cellular substrate for learning and memory, it is less clear how a…”
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