Search Results - "Dudley, Samuel C."

Magnesium, Oxidative Stress, Inflammation, and Cardiovascular Disease by Liu, Man, Dudley, Jr, Samuel C

“…Hypomagnesemia is commonly observed in heart failure, diabetes mellitus, hypertension, and cardiovascular diseases. Low serum magnesium (Mg) is a predictor for…”
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Evidence for Inflammation as a Driver of Atrial Fibrillation by Zhou, Xiaoxu, Dudley, Jr, Samuel C

“…Atrial fibrillation (AF) is one of the most common types of arrhythmias and increases cardiovascular morbidity and mortality. Current therapeutic approaches to…”
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Reactive Oxygen Species Originating From Mitochondria Regulate the Cardiac Sodium Channel by Liu, Man, Liu, Hong, Dudley, Samuel C

“…RATIONALE:Pyridine nucleotides regulate the cardiac Na current (INa) through generation of reactive oxygen species (ROS). OBJECTIVE:We investigated the source…”
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Beyond Ion Homeostasis: Hypomagnesemia, Transient Receptor Potential Melastatin Channel 7, Mitochondrial Function, and Inflammation by Liu, Man, Dudley, Jr, Samuel C

“…As the second most abundant intracellular divalent cation, magnesium (Mg ) is essential for cell functions, such as ATP production, protein/DNA synthesis,…”
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miR-448 regulates potassium voltage-gated channel subfamily A member 4 (KCNA4) in ischemia and heart failure by Kang, Gyeoung-Jin, Xie, An, Kim, Eunji, Dudley, Samuel C.

“…MicroRNA miR-448 mediates some of the effects of ischemia on arrhythmic risk. Potassium voltage-gated channel subfamily A member 4 (KCNA4) encodes a Kv1.4…”
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Inhibition of the unfolded protein response reduces arrhythmia risk after myocardial infarction by Liu, Man, Liu, Hong, Parthiban, Preethy, Kang, Gyeoung-Jin, Shi, Guangbin, Feng, Feng, Zhou, Anyu, Gu, Lianzhi, Karnopp, Courtney, Tolkacheva, Elena G, Dudley, Jr, Samuel C

“…Ischemic cardiomyopathy is associated with an increased risk of sudden death, activation of the unfolded protein response (UPR), and reductions in multiple…”
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Diastolic Dysfunction: Potential New Diagnostics and Therapies by Jeong, Euy-Myoung, Dudley, Samuel C., Jr

“…Despite the growing number of patients affected, the understanding of diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF) is still…”
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Short term Pm2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy by Yue, Wenhui, Tong, Lei, Liu, Xiaohong, Weng, Xinyu, Chen, Xiaoyu, Wang, Dongzhi, Dudley, Samuel C, Weir, E Kenneth, Ding, Wenjun, Lu, Zhongbing, Xu, Yawei, Chen, Yingjie

“…Heart failure (HF) is the single largest cause for increased hospitalization after fine particulate matter (PM2.5) exposure. Patients with left HF often…”
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Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias by Liu, Man, Dudley, Jr, Samuel C

“…The unfolded protein response (UPR) has been extensively investigated in neurological diseases and diabetes, while its function in heart disease is less well…”
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Mutation in glycerol-3-phosphate dehydrogenase 1-like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias by LONDON, Barry, MICHALEC, Michael, BATY, Catherine J, LAGANA, Stephen, ALEONG, Ryan, GUTMANN, Rebecca, ACKERMAN, Michael J, MCNAMARA, Dennis M, WEISS, Raul, DUDLEY, Samuel C, MEHDI, Haider, XIAODONG ZHU, KERCHNER, Laurie, SANYAL, Shamarendra, VISWANATHAN, Prakash C, PFAHNL, Arnold E, SHANG, Lijuan L, MADHUSUDANAN, Mohan

“…Brugada syndrome is a rare, autosomal-dominant, male-predominant form of idiopathic ventricular fibrillation characterized by a right bundle-branch block and…”
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TRPM7 kinase mediates hypomagnesemia-induced seizure-related death by Liu, Man, Liu, Hong, Feng, Feng, Krook-Magnuson, Esther, Dudley, Samuel C.

“…Hypomagnesemia (HypoMg) can cause seizures and death, but the mechanism is unknown. Transient receptor potential cation channel subfamily M 7 (TRPM7) is a Mg…”
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Mitochondrial Ca2+ flux modulates spontaneous electrical activity in ventricular cardiomyocytes by Xie, An, Zhou, Anyu, Liu, Hong, Shi, Guangbin, Liu, Man, Boheler, Kenneth R, Dudley, Jr, Samuel C

“…Ca2+ release from sarcoplasmic reticulum (SR) is known to contribute to automaticity via the cytoplasmic Na+-Ca2+ exchanger (NCX). Mitochondria participate in…”
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Cardiac sodium channel mutations: why so many phenotypes? by Liu, Man, Yang, Kai-Chien, Dudley, Samuel C.

“…Mutations in the SCN5A gene, which encodes the cardiac sodium channel, are well known to cause gain or loss of channel function and, consequently, various…”
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Mechanisms of Sudden Cardiac Death: Oxidants and Metabolism by Yang, Kai-Chien, Kyle, John W, Makielski, Jonathan C, Dudley, Samuel C

“…Ventricular arrhythmia is the leading cause of sudden cardiac death (SCD). Deranged cardiac metabolism and abnormal redox state during cardiac diseases foment…”
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Characterization and Functionality of Cardiac Progenitor Cells in Congenital Heart Patients by MISHRA, Rachana, VIJAYAN, Kalpana, BACKER, Carl L, DUDLEY, Samuel C, WOLD, Loren E, KAUSHAL, Sunjay, COLLETTI, Evan J, HARRINGTON, Daniel A, MATTHIESEN, Thomas S, SIMPSON, David, SAIK KIA GOH, WALKER, Brandon L, ALMEIDA-PORADA, Graça, WANG, Deli

“…Human cardiac progenitor cells (hCPCs) may promote myocardial regeneration in adult ischemic myocardium. The regenerative capacity of hCPCs in young patients…”
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Ranolazine Improves Cardiac Diastolic Dysfunction Through Modulation of Myofilament Calcium Sensitivity by Lovelock, Joshua D, Monasky, Michelle M, Jeong, Euy-Myoung, Lardin, Harvey A, Liu, Hong, Patel, Bindiya G, Taglieri, Domenico M, Gu, Lianzhi, Kumar, Praveen, Pokhrel, Narayan, Zeng, Dewan, Belardinelli, Luiz, Sorescu, Dan, Solaro, R John, Dudley, Samuel C

“…RATIONALE:Previously, we demonstrated that a deoxycorticosterone acetate (DOCA)-salt hypertensive mouse model produces cardiac oxidative stress and diastolic…”
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Targeting PERK to treat arrhythmias by Liu, Man, Kang, Gyeoung-Jin, Dudley, Samuel C.

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Role of Mitochondrial Oxidative Stress in Glucose Tolerance, Insulin Resistance, and Cardiac Diastolic Dysfunction by Jeong, Euy‐Myoung, Chung, Jaehoon, Liu, Hong, Go, Yeongju, Gladstein, Scott, Farzaneh‐Far, Afshin, Lewandowski, E. Douglas, Dudley, Samuel C.

“…Background Diabetes mellitus (DM) is associated with mitochondrial oxidative stress. We have shown that myocardial oxidative stress leads to diastolic…”
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Uncoupled Cardiac Nitric Oxide Synthase Mediates Diastolic Dysfunction by SILBERMAN, Gad A, FAN, Tai-Hwang M, WOLSKA, Beata M, DIKALOV, Sergey, HARRISON, David G, DUDLEY, Samuel C, HONG LIU, ZHE JIAO, XIAO, Hong D, LOVELOCK, Joshua D, BOULDEN, Beth M, WIDDER, Julian, FREDD, Scott, BERNSTEIN, Kenneth E

“…Heart failure with preserved ejection fraction is 1 consequence of hypertension and is caused by impaired cardiac diastolic relaxation. Nitric oxide (NO) is a…”
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Preventing unfolded protein response-induced ion channel dysregulation to treat arrhythmias by Liu, Man, Kang, Gyeoung-Jin, Dudley, Samuel C.

“…Cardiomyopathies are associated with arrhythmias and cardiac ion channel downregulation. This downregulation is arrhythmogenic. Paradoxically, antiarrhythmic…”
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