Search Results - "Dudley, Andrew T."

Noncanonical frizzled signaling regulates cell polarity of growth plate chondrocytes by Li, Yuwei, Dudley, Andrew T

“…Bone growth is driven by cell proliferation and the subsequent hypertrophy of chondrocytes arranged in columns of discoid cells that resemble stacks of coins…”
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Steered molecular dynamic simulations reveal Marfan syndrome mutations disrupt fibrillin-1 cbEGF domain mechanosensitive calcium binding by Haller, Stephen J., Roitberg, Adrian E., Dudley, Andrew T.

“…Marfan syndrome (MFS) is a highly variable genetic connective tissue disorder caused by mutations in the calcium binding extracellular matrix glycoprotein…”
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New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure by Espinoza, Daniel O, Huang, Tian Lian, Norris, Andrew W, Yamamoto, Yuji, Schulz, Tim J, Dudley, Andrew T, Tran, Thien T, Kahn, C. Ronald, Tseng, Yu-Hua, Taniguchi, Cullen M, Kulkarni, Rohit N, Ahrens, Molly J, Kokkotou, Efi, Suzuki, Ryo, Winnay, Jonathon N

“…Adipose tissue is central to the regulation of energy balance. Two functionally different types of fat are present in mammals: white adipose tissue, the…”
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A dynamic cell adhesion surface regulates tissue architecture in growth plate cartilage by Romereim, Sarah M, Conoan, Nicholas H, Chen, Baojiang, Dudley, Andrew T

“…The architecture and morphogenetic properties of tissues are founded in the tissue-specific regulation of cell behaviors. In endochondral bones, the growth…”
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Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins by Ahrens, Molly J, Li, Yuwei, Jiang, Hongmei, Dudley, Andrew T

“…Proteins that are localized to the cell surface via glycosylphosphatidylinositol (gpi) anchors have been proposed to regulate cell signaling and cell adhesion…”
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Calcium/calmodulin-dependent protein kinase II activity regulates the proliferative potential of growth plate chondrocytes by Li, Yuwei, Ahrens, Molly J, Wu, Amy, Liu, Jennifer, Dudley, Andrew T

“…For tissues that develop throughout embryogenesis and into postnatal life, the generation of differentiated cells to promote tissue growth is at odds with the…”
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A re-examination of proximodistal patterning during vertebrate limb development by Tabin, Clifford J, Dudley, Andrew T, Ros, María A

“…The 'progress zone' model provides a framework for understanding progressive development of the vertebrate limb. This model holds that undifferentiated cells…”
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Pneumatic microfluidic cell compression device for high-throughput study of chondrocyte mechanobiology by Lee, Donghee, Erickson, Alek, You, Taesun, Dudley, Andrew T, Ryu, Sangjin

“…Hyaline cartilage is a specialized type of connective tissue that lines many moveable joints (articular cartilage) and contributes to bone growth (growth plate…”
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Chemical Pretreatment of Growth Plate Cartilage Increases Immunofluorescence Sensitivity by Ahrens, Molly J., Dudley, Andrew T.

“…Immunofluorescence detection of proteins in growth plate cartilage is often unsuccessful because of innate autofluorescence, fixative-induced fluorescence, and…”
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A re‐evaluation of two key reagents for in vivo studies of Wnt signaling by Ahrens, Molly J., Romereim, Sarah, Dudley, Andrew T.

“…Conditional mutations and transcription‐based reporters are important new tools for exploring the dynamic functions of biological pathways in vivo. While…”
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Role of Mammalian Ecdysoneless in Cell Cycle Regulation by Kim, Jun Hyun, Gurumurthy, Channabasavaiah Basavaraju, Naramura, Mayumi, Zhang, Ying, Dudley, Andrew T., Doglio, Lynn, Band, Hamid, Band, Vimla

“…The Ecdysoneless (Ecd) protein is required for cell-autonomous roles in development and oogenesis in Drosophila, but the function of its evolutionarily…”
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N-cadherin and β1 integrin coordinately regulate growth plate cartilage architecture by Greer, Sydney E., Haller, Stephen J., Lee, Donghee, Dudley, Andrew T.

“…Spatial and temporal regulation of chondrocyte maturation in the growth plate drives growth of many bones. One essential event to generate the ordered cell…”
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Extracellular mechanotransduction by Haller, Stephen J, Dudley, Andrew T

“…We highlight the force-sensing function of extracellular matrix and present a complementary mechanotransduction paradigm…”
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Cell polarity: The missing link in skeletal morphogenesis? by Romereim, Sarah M., Dudley, Andrew T.

“…Despite extensive genetic analysis of the dynamic multi-phase process that transforms a small population of lateral plate mesoderm into the mature limb…”
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Dynamic hyaluronic acid hydrogel with covalent linked gelatin as an anti-oxidative bioink for cartilage tissue engineering by Shi, Wen, Fang, Fang, Kong, Yunfan, Greer, Sydney E, Kuss, Mitchell, Liu, Bo, Xue, Wen, Jiang, Xiping, Lovell, Paul, Mohs, Aaron M, Dudley, Andrew T, Li, Tieshi, Duan, Bin

“…In the past decade, cartilage tissue engineering has arisen as a promising therapeutic option for degenerative joint diseases, such as osteoarthritis, in the…”
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A Facile Strategy for the Fabrication of Cell‐Laden Porous Alginate Hydrogels based on Two‐Phase Aqueous Emulsions by Xue, Wen, Lee, Donghee, Kong, Yunfan, Kuss, Mitchell, Huang, Ying, Kim, Taesung, Chung, Soonkyu, Dudley, Andrew T., Ro, Seung‐Hyun, Duan, Bin

“…Porous alginate (Alg) hydrogels possess many advantages as cell carriers. However, current pore generation methods require either complex or harsh fabrication…”
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3D printed alginate bead generator for high-throughput cell culture by Lee, Donghee, Greer, Sydney E., Kuss, Mitchell A., An, Yang, Dudley, Andrew T.

“…Alginate hydrogel beads are a common platform for generating 3D cell cultures in biomedical research. Simple methods for bead generation using a manual…”
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A Tunable, Three-Dimensional In Vitro Culture Model of Growth Plate Cartilage Using Alginate Hydrogel Scaffolds by Erickson, Alek G, Laughlin, Taylor D, Romereim, Sarah M, Sargus-Patino, Catherine N, Pannier, Angela K, Dudley, Andrew T

“…Defining the final size and geometry of engineered tissues through precise control of the scalar and vector components of tissue growth is a necessary…”
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Impact of anaesthetics and analgesics on fetal growth in the mouse by Thaete, Larry G, Levin, Stephen I, Dudley, Andrew T

“…Common anaesthetic and analgesic agents used during pregnancy in mice have been observed to cause fetal growth restriction. We investigated the impact of…”
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Constructive antagonism in limb development by Dudley, Andrew T, Tabin, Clifford J

“…Several advances have been made in our understanding of the control of the growth and patterning of embryonic limbs. Development of the vertebrate limb is…”
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