Synthesis, structure, and biological properties of some 8α analogues of steroid estrogens with fluorine in position 2

A total synthesis of 8 alpha analogues of steroid estrogens with fluorine in position 2 was achieved. Structural features of these compounds were studied by the example of 17 beta -acetoxy-2-fluoro-3-methoxy-8 alpha -estra-1,3,5(10)-triene. It was shown that the 8 alpha analogues of 2-fluorosubstitu...

Full description

Saved in:

Bibliographic Details
Published in:	Russian journal of bioorganic chemistry Vol. 33; no. 3; pp. 293 - 301
Main Authors:	Belov, V. N., Dudkin, V. Yu, Urusova, E. A., Starova, G. L., Selivanov, S. I., Nikolaev, S. V., Eshchenko, N. D., Morozkina, S. N., Shavva, A. G.
Format:	Journal Article
Language:	English
Published:	01-05-2007
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	A total synthesis of 8 alpha analogues of steroid estrogens with fluorine in position 2 was achieved. Structural features of these compounds were studied by the example of 17 beta -acetoxy-2-fluoro-3-methoxy-8 alpha -estra-1,3,5(10)-triene. It was shown that the 8 alpha analogues of 2-fluorosubstituted steroid estrogens have a low uterotropic activity and retain the osteoprotective and hypocholesterolemic activities.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	1068-1620 1573-9163 1608-330X
DOI:	10.1134/S1068162007030041