Search Results - "Dudek, Steven"

Natural Killer Cell Ligands: Another Source of Heterogeneity in Acute Lung Injury Pathophysiology? by Letsiou, Eleftheria, Dudek, Steven M

“…The acute respiratory distress syndrome (ARDS) is a common pathophysiological process marked by diffuse inflammatory lung damage in response to multiple…”
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Secretory Phospholipase A2 Enzymes in Acute Lung Injury by Letsiou, Eleftheria, Htwe, Yu Maw, Dudek, Steven M.

“…The secretory phospholipase A 2 (sPLA 2 ) group of secreted enzymes hydrolyze phospholipids and lead to the production of multiple biologically active lipid…”
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Effect of ACE mutations on blood ACE phenotype parameters by Kryukova, Olga V, Korostin, Dmitry O, Belova, Vera A, Cheranev, Valery V, Repinskaia, Zhanna A, Uporov, Igor V, Dudek, Steven M, Kost, Olga A, Rebrikov, Denis V, Danilov, Sergei M

“…Analysis of existing mutations of Angiotensin-I-Converting Enzyme (ACE) led us to hypothesize that the carriers of damaging ACE mutations (accompanied by low…”
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Regulation of vascular permeability by sphingosine 1-phosphate by Wang, Lichun, Dudek, Steven M.

“…A significant and sustained increase in vascular permeability is a hallmark of acute inflammatory diseases such as acute lung injury (ALI) and sepsis and is an…”
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Functional roles of CD26/DPP4 in lipopolysaccharide-induced lung injury by Sato, Shun, Kawasaki, Takeshi, Hatano, Ryo, Koyanagi, Yu, Takahashi, Yukiko, Ohnuma, Kei, Morimoto, Chikao, Dudek, Steven M, Tatsumi, Koichiro, Suzuki, Takuji

“…Acute respiratory distress syndrome (ARDS) is characterized by dysregulated inflammation and increased permeability of lung microvascular cells…”
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Cortactin in Lung Cell Function and Disease by Bandela, Mounica, Belvitch, Patrick, Garcia, Joe G N, Dudek, Steven M

“…Cortactin (CTTN) is an actin-binding and cytoskeletal protein that is found in abundance in the cell cortex and other peripheral structures of most cell types…”
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Angiocrine Sphingosine-1-Phosphate Activation of S1PR2-YAP Signaling Axis in Alveolar Type II Cells Is Essential for Lung Repair by Chen, Qian, Rehman, Jalees, Chan, Manwai, Fu, Panfeng, Dudek, Steven M., Natarajan, Viswanathan, Malik, Asrar B., Liu, Yuru

“…Lung alveolar epithelium is composed of alveolar type I (AT1) and type II (AT2) cells. AT1 cells mediate gas exchange, whereas AT2 cells act as progenitor…”
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Parkin regulates lipopolysaccharide-induced proinflammatory responses in acute lung injury by Letsiou, Eleftheria, Sammani, Saad, Wang, Huashan, Belvitch, Patrick, Dudek, Steven M.

“…The acute respiratory distress syndrome (ARDS) is a serious condition resulting from direct or indirect lung injury that is associated with high mortality and…”
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Epigenetic mechanisms mediate cytochrome P450 1A1 expression and lung endothelial injury caused by MRSA in vitro and in vivo by Ha, Alison W., Meliton, Lucille N., Chen, Weiguo, Wang, Lichun, Maienschein‐Cline, Mark, Jacobson, Jeffrey R., Letsiou, Eleftheria, Dudek, Steven M.

“…Methicillin‐resistant Staphylococcus aureus (MRSA) is a common cause of severe pneumonia and acute respiratory distress syndrome (ARDS). To advance our…”
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Imatinib attenuates inflammation and vascular leak in a clinically relevant two-hit model of acute lung injury by Rizzo, Alicia N, Sammani, Saad, Esquinca, Adilene E, Jacobson, Jeffrey R, Garcia, Joe G N, Letsiou, Eleftheria, Dudek, Steven M

“…Acute lung injury/acute respiratory distress syndrome (ALI/ARDS), an illness characterized by life-threatening vascular leak, is a significant cause of…”
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Endothelial eNAMPT amplifies pre-clinical acute lung injury: efficacy of an eNAMPT-neutralising monoclonal antibody by Quijada, Hector, Bermudez, Tadeo, Kempf, Carrie L, Valera, Daniel G, Garcia, Alexander N, Camp, Sara M, Song, Jin H, Franco, Evelyn, Burt, Jessica K, Sun, Belinda, Mascarenhas, Joseph B, Burns, Kimberlie, Gaber, Amir, Oita, Radu C, Reyes Hernon, Vivian, Barber, Christy, Moreno-Vinasco, Liliana, Sun, Xiaoguang, Cress, Anne E, Martin, Diego, Liu, Zhonglin, Desai, Ankit A, Natarajan, Viswanathan, Jacobson, Jeffrey R, Dudek, Steven M, Bime, Christian, Sammani, Saad, Garcia, Joe G N

“…The severe acute respiratory syndrome coronavirus 2/coronavirus disease 2019 pandemic has highlighted the serious unmet need for effective therapies that…”
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Genetic and epigenetic regulation of cortactin (CTTN) by inflammatory factors and mechanical stress in human lung endothelial cells by Sun, Xiaoguang, Sun, Belinda, Sammani, Saad, Dudek, Steven M, Belvitch, Patrick, Camp, Sara M, Zhang, Donna, Bime, Christian, Garcia, Joe G N

“…Cortactin, an actin-binding cytoskeletal protein, plays a crucial role in maintaining endothelial cell (EC) barrier integrity and regulating vascular…”
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Genetic and epigenetic regulation of the non-muscle myosin light chain kinase isoform by lung inflammatory factors and mechanical stress by Sun, Xiaoguang, Sun, Belinda L, Sammani, Saad, Bermudez, Tadeo, Dudek, Steven M, Camp, Sara M, Garcia, Joe G N

“…The myosin light chain kinase gene, MYLK, encodes three proteins via unique promoters, including the non-muscle isoform of myosin light chain kinase (nmMLCK),…”
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Lamellipodia dynamics and microrheology in endothelial cell paracellular gap closure by Arce, Fernando Teran, Younger, Scott, Gaber, Amir A, Mascarenhas, Joseph B, Rodriguez, Marisela, Dudek, Steven M, Garcia, Joe G N

“…Vascular endothelial cells (ECs) form a semipermeable barrier separating vascular contents from the interstitium, thereby regulating the movement of water and…”
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Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury by Natarajan, Viswanathan, Dudek, Steven M, Jacobson, Jeffrey R, Moreno-Vinasco, Liliana, Huang, Long Shuang, Abassi, Taimur, Mathew, Biji, Zhao, Yutong, Wang, Lichun, Bittman, Robert, Weichselbaum, Ralph, Berdyshev, Evgeny, Garcia, Joe G N

“…Acute lung injury (ALI) attributable to sepsis or mechanical ventilation and subacute lung injury because of ionizing radiation (RILI) share profound increases…”
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Targeting Abl Kinases to Regulate Vascular Leak During Sepsis and Acute Respiratory Distress Syndrome by Rizzo, Alicia N, Aman, Jurjan, van Nieuw Amerongen, Geerten P, Dudek, Steven M

“…The vascular endothelium separates circulating fluid and inflammatory cells from the surrounding tissues. Vascular leak occurs in response to wide-spread…”
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MRSA-induced endothelial permeability and acute lung injury are attenuated by FTY720 S-phosphonate by Wang, Lichun, Letsiou, Eleftheria, Wang, Huashan, Belvitch, Patrick, Meliton, Lucille N, Brown, Mary E, Bandela, Mounica, Chen, Jiwang, Garcia, Joe G N, Dudek, Steven M

“…Disruption of the lung endothelial barrier is a hallmark of acute respiratory distress syndrome (ARDS), for which no effective pharmacologic treatments exist…”
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Endothelial Glycocalyx Repair: Building a Wall to Protect the Lung during Sepsis by Rizzo, Alicia N, Dudek, Steven M

“…Within the lung, sepsis frequently causes inflammation-induced disruption of the pulmonary vasculature, alveolar edema, refractory hypoxemia, and ultimately…”
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Pathologic mechanical stress and endotoxin exposure increases lung endothelial microparticle shedding by Letsiou, Eleftheria, Sammani, Saad, Zhang, Wei, Zhou, Tong, Quijada, Hector, Moreno-Vinasco, Liliana, Dudek, Steven M, Garcia, Joe G N

“…Acute lung injury (ALI) results from infectious challenges and from pathologic lung distention produced by excessive tidal volume delivered during mechanical…”
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ATP promotes cell survival via regulation of cytosolic [Ca2+] and Bcl-2/Bax ratio in lung cancer cells by Song, Shanshan, Jacobson, Krista N, McDermott, Kimberly M, Reddy, Sekhar P, Cress, Anne E, Tang, Haiyang, Dudek, Steven M, Black, Stephen M, Garcia, Joe G N, Makino, Ayako, Yuan, Jason X-J

“…Adenosine triphosphate (ATP) is a ubiquitous extracellular messenger elevated in the tumor microenvironment. ATP regulates cell functions by acting on…”
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