Search Results - "Dudek, Serena M"

Regulation of synaptic plasticity in hippocampal area CA2 by Carstens, Kelly E, Dudek, Serena M

“…•Pyramidal neurons in hippocampal area CA2 are molecularly distinct from neighboring CA1 and CA3 pyramidal cells.•Schaffer collateral synapses onto CA2…”
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Hippocampal Subregions Express Distinct Dendritic Transcriptomes that Reveal Differences in Mitochondrial Function in CA2 by Farris, Shannon, Ward, James M., Carstens, Kelly E., Samadi, Mahsa, Wang, Yu, Dudek, Serena M.

“…RNA localization is one mechanism neurons use to spatially and temporally regulate gene expression at synapses. Here, we test the hypothesis that cells…”
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Social and novel contexts modify hippocampal CA2 representations of space by Alexander, Georgia M., Farris, Shannon, Pirone, Jason R., Zheng, Chenguang, Colgin, Laura L., Dudek, Serena M.

“…The hippocampus supports a cognitive map of space and is critical for encoding declarative memory (who, what, when and where). Recent studies have implicated…”
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Recombinase-Dependent Mouse Lines for Chemogenetic Activation of Genetically Defined Cell Types by Sciolino, Natale R., Plummer, Nicholas W., Chen, Yu-Wei, Alexander, Georgia M., Robertson, Sabrina D., Dudek, Serena M., McElligott, Zoe A., Jensen, Patricia

“…Chemogenetic technologies, including the mutated human Gq-coupled M3 muscarinic receptor (hM3Dq), have greatly facilitated our ability to directly link changes…”
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CA2 neuronal activity controls hippocampal low gamma and ripple oscillations by Alexander, Georgia M, Brown, Logan Y, Farris, Shannon, Lustberg, Daniel, Pantazis, Caroline, Gloss, Bernd, Plummer, Nicholas W, Jensen, Patricia, Dudek, Serena M

“…Hippocampal oscillations arise from coordinated activity among distinct populations of neurons and are associated with cognitive functions. Much progress has…”
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Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5 by Hartmann, Jakob, Bajaj, Thomas, Klengel, Claudia, Chatzinakos, Chris, Ebert, Tim, Dedic, Nina, McCullough, Kenneth M., Lardenoije, Roy, Joëls, Marian, Meijer, Onno C., McCann, Katharine E., Dudek, Serena M., Sarabdjitsingh, R. Angela, Daskalakis, Nikolaos P., Klengel, Torsten, Gassen, Nils C., Schmidt, Mathias V., Ressler, Kerry J.

“…Responding to different dynamic levels of stress is critical for mammalian survival. Disruption of mineralocorticoid receptor (MR) and glucocorticoid receptor…”
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Hippocampus and Entorhinal Cortex Recruit Cholinergic and NMDA Receptors Separately to Generate Hippocampal Theta Oscillations by Gu, Zhenglin, Alexander, Georgia M., Dudek, Serena M., Yakel, Jerrel L.

“…Although much progress has been made in understanding type II theta rhythm generation under urethane anesthesia, less is known about the mechanisms underlying…”
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Synaptic Plasticity (and the Lack Thereof) in Hippocampal CA2 Neurons by Zhao, Meilan, Choi, Yun-Sik, Obrietan, Karl, Dudek, Serena M

“…The hippocampus is critical for some forms of memory and spatial navigation, but previous research has mostly neglected the CA2, a unique region situated…”
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Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II by Dudek, Serena M, Saha, Ramendra N, Wissink, Erin M, Bailey, Emma R, Zhao, Meilan, Fargo, David C, Hwang, Ji-Yeon, Daigle, Kelly R, Fenn, J Daniel, Adelman, Karen

“…Immediate early genes are rapidly transcribed in response to neuronal activity, but the underlying mechanism is unclear. The authors show that this rapid…”
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Synapse elimination accompanies functional plasticity in hippocampal neurons by Bastrikova, Natalia, Gardner, Gregory A, Reece, Jeff M, Jeromin, Andreas, Dudek, Serena M

“…A critical component of nervous system development is synapse elimination during early postnatal life, a process known to depend on neuronal activity. Changes…”
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Adenosine A1 Receptor-Mediated Synaptic Depression in the Developing Hippocampal Area CA2 by Caruana, Douglas A., Dudek, Serena M.

“…Immunolabeling for adenosine A1 receptors (A1Rs) is high in hippocampal area CA2 in adult rats, and the potentiating effects of caffeine or other A1R-selective…”
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Specific Proteomes of Hippocampal Regions CA2 and CA1 Reveal Proteins Linked to the Unique Physiology of Area CA2 by Gerber, Kyle J, Dammer, Eric B, Duong, Duc M, Deng, Qiudong, Dudek, Serena M, Seyfried, Nicholas T, Hepler, John R

“…The hippocampus is well established as an essential brain center for learning and memory. Within the hippocampus, recent studies show that area CA2 is…”
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Caffeine-induced synaptic potentiation in hippocampal CA2 neurons by Simons, Stephen B, Caruana, Douglas A, Zhao, Meilan, Dudek, Serena M

“…A1 adenosine receptor is antagonized by caffeine and is highly expressed in the CA2 layer of rodent hippocampus. This study now shows that caffeine can induce…”
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Regional differences in hippocampal calcium handling provide a cellular mechanism for limiting plasticity by Simons, Stephen B, Escobedo, Yasmin, Yasuda, Ryohei, Dudek, Serena M

“…Although much is known about the mechanisms underlying synaptic plasticity, the cellular mechanisms that negatively regulate plasticity in some brain regions…”
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RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory by Lee, Sarah Emerson, Simons, Stephen B., Heldt, Scott A., Zhao, Meilan, Schroeder, Jason P., Vellano, Christopher P., Cowan, D. Patrick, Ramineni, Suneela, Yates, Cindee K., Feng, Yue, Smith, Yoland, Sweatt, J. David, Weinshenker, David, Ressler, Kerry J., Dudek, Serena M., Hepler, John R.

“…Learning and memory have been closely linked to strengthening of synaptic connections between neurons (i.e., synaptic plasticity) within the dentate gyrus…”
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Optimized Method for Robust Transcriptome Profiling of Minute Tissues Using Laser Capture Microdissection and Low-Input RNA-Seq by Farris, Shannon, Wang, Yu, Ward, James M, Dudek, Serena M

“…Obtaining high quality RNA from complex biological tissues, such as the brain, is needed for establishing high-fidelity cell-type specific transcriptomes…”
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GIRK2 splice variants and neuronal G protein-gated K+ channels: implications for channel function and behavior by Marron Fernandez de Velasco, Ezequiel, Zhang, Lei, N. Vo, Baovi, Tipps, Megan, Farris, Shannon, Xia, Zhilian, Anderson, Allison, Carlblom, Nicholas, Weaver, C. David, Dudek, Serena M., Wickman, Kevin

“…Many neurotransmitters directly inhibit neurons by activating G protein-gated inwardly rectifying K + (GIRK) channels, thereby moderating the influence of…”
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Rediscovering area CA2: unique properties and functions by Dudek, Serena M., Alexander, Georgia M., Farris, Shannon

“…Key Points Hippocampal area CA2, contrary to popular perception, has a distinct molecular profile and connectivity compared with its neighbouring areas CA1 and…”
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Late-phase long-term potentiation: getting to the nucleus by Dudek, Serena M, Adams, J. Paige

“…New mRNA must be transcribed in order to consolidate changes in synaptic strength. But how are events at the synapse communicated to the nucleus? Some research…”
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Morphological and molecular markers of mouse area CA2 along the proximodistal and dorsoventral hippocampal axes by Radzicki, Daniel, Chong, Sarah, Dudek, Serena M.

“…Hippocampal area CA2 is a molecularly and functionally distinct region of the hippocampus that has classically been defined as the area with large pyramidal…”
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