Search Results - "Duddy, Graham"

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases by Steger, Martin, Tonelli, Francesca, Ito, Genta, Davies, Paul, Trost, Matthias, Vetter, Melanie, Wachter, Stefanie, Lorentzen, Esben, Duddy, Graham, Wilson, Stephen, Baptista, Marco As, Fiske, Brian K, Fell, Matthew J, Morrow, John A, Reith, Alastair D, Alessi, Dario R, Mann, Matthias

“…Mutations in Park8, encoding for the multidomain Leucine-rich repeat kinase 2 (LRRK2) protein, comprise the predominant genetic cause of Parkinson's disease…”
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Tumors induce de novo steroid biosynthesis in T cells to evade immunity by Mahata, Bidesh, Pramanik, Jhuma, van der Weyden, Louise, Polanski, Krzysztof, Kar, Gozde, Riedel, Angela, Chen, Xi, Fonseca, Nuno A., Kundu, Kousik, Campos, Lia S., Ryder, Edward, Duddy, Graham, Walczak, Izabela, Okkenhaug, Klaus, Adams, David J., Shields, Jacqueline D., Teichmann, Sarah A.

“…Tumors subvert immune cell function to evade immune responses, yet the complex mechanisms driving immune evasion remain poorly understood. Here we show that…”
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Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors by Ito, Genta, Katsemonova, Kristina, Tonelli, Francesca, Lis, Pawel, Baptista, Marco A S, Shpiro, Natalia, Duddy, Graham, Wilson, Steve, Ho, Philip Wing-Lok, Ho, Shu-Leong, Reith, Alastair D, Alessi, Dario R

“…Autosomal dominant mutations that activate the leucine-rich repeat kinase 2 (LRRK2) cause inherited Parkinson's disease. Recent work has revealed that LRRK2…”
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Donor template delivery by recombinant adeno-associated virus for the production of knock-in mice by Duddy, Graham, Courtis, Katherine, Horwood, Juliette, Olsen, Jessica, Horsler, Helen, Hodgson, Tina, Varsani-Brown, Sunita, Abdullah, Abdullah, Denti, Laura, Lane, Hollie, Delaqua, Fabio, Janzen, Julia, Strom, Molly, Rosewell, Ian, Crawley, Katharine, Davies, Benjamin

“…The ability of recombinant adeno-associated virus to transduce preimplantation mouse embryos has led to the use of this delivery method for the production of…”
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Pathological mechanisms and candidate therapeutic approaches in the hearing loss of mice carrying human MIR96 mutations by Lewis, Morag A, Lachgar-Ruiz, Maria, Di Domenico, Francesca, Duddy, Graham, Chen, Jing, Fernandez, Sergio, Morin, Matias, Williams, Gareth, Moreno Pelayo, Miguel Angel, Steel, Karen P

“…Progressive hearing loss is a common problem in the human population with no effective therapeutics currently available. However, it has a strong genetic…”
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Targeting apoptosis signalling kinase-1 (ASK-1) does not prevent the development of neuropathy in streptozotocin-induced diabetic mice by Newton, Victoria L, Ali, Sumia, Duddy, Graham, Whitmarsh, Alan J, Gardiner, Natalie J

“…Apoptosis signal-regulating kinase-1 (ASK1) is a mitogen-activated protein 3 kinase (MAPKKK/MAP3K) which lies upstream of the stress-activated MAPKs, JNK and…”
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Characterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target by Deakin, Angela, Duddy, Graham, Wilson, Steve, Harrison, Steve, Latcham, Judi, Fulleylove, Mick, Fung, Sylvia, Smith, Jason, Pedrick, Mike, McKevitt, Tom, Felton, Leigh, Morley, Joanne, Quint, Diana, Fattah, Dilniya, Hayes, Brian, Gough, Jade, Solari, Roberto

“…Interleukin-2 inducible tyrosine kinase (ITK) is expressed in T cells and plays a critical role in signalling through the T cell receptor. Evidence, mainly…”
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BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes by Harrison, Steve M, Harper, Alex J, Hawkins, Julie, Duddy, Graham, Grau, Evelyn, Pugh, Pippa L, Winter, Panida H, Shilliam, Claire S, Hughes, Zoë A, Dawson, Lee A, Gonzalez, M Isabel, Upton, Neil, Pangalos, Menelas N, Dingwall, Colin

“…BACE1 is a key enzyme in the generation of Abeta, the major component of senile plaques in the brains of Alzheimer's disease patients. We have generated…”
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Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation by Henriksson, Johan, Chen, Xi, Gomes, Tomás, Ullah, Ubaid, Meyer, Kerstin B., Miragaia, Ricardo, Duddy, Graham, Pramanik, Jhuma, Yusa, Kosuke, Lahesmaa, Riitta, Teichmann, Sarah A.

“…T helper type 2 (Th2) cells are important regulators of mammalian adaptive immunity and have relevance for infection, autoimmunity, and tumor immunology. Using…”
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Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome by Balmus, Gabriel, Larrieu, Delphine, Barros, Ana C., Collins, Casey, Abrudan, Monica, Demir, Mukerrem, Geisler, Nicola J., Lelliott, Christopher J., White, Jacqueline K., Karp, Natasha A., Atkinson, James, Kirton, Andrea, Jacobsen, Matt, Clift, Dean, Rodriguez, Raphael, Adams, David J., Jackson, Stephen P.

“…Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare, but devastating genetic disease characterized by segmental premature aging, with cardiovascular disease…”
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Evaluation of expression and function of the H+/myo-inositol transporter HMIT by Di Daniel, Elena, Mok, Man H S, Mead, Emma, Mutinelli, Chiara, Zambello, Erika, Caberlotto, Laura L, Pell, Theresa J, Langmead, Christopher J, Shah, Ajit J, Duddy, Graham, Kew, James N C, Maycox, Peter R

“…The phosphoinositide (PIns) signalling pathway regulates a series of neuronal processes, such as neurotransmitter release, that are thought to be altered in…”
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Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines by Elrick, Hillary, Peterson, Kevin A., Willis, Brandon J., Lanza, Denise G., Acar, Elif F., Ryder, Edward J., Teboul, Lydia, Kasparek, Petr, Birling, Marie-Christine, Adams, David J., Bradley, Allan, Braun, Robert E., Brown, Steve D., Caulder, Adam, Codner, Gemma F., DeMayo, Francesco J., Dickinson, Mary E., Doe, Brendan, Duddy, Graham, Gertsenstein, Marina, Goodwin, Leslie O., Hérault, Yann, Lintott, Lauri G., Lloyd, K. C. Kent, Lorenzo, Isabel, Mackenzie, Matthew, Mallon, Ann-Marie, McKerlie, Colin, Parkinson, Helen, Ramirez-Solis, Ramiro, Seavitt, John R., Sedlacek, Radislav, Skarnes, William C., Smedley, Damien, Wells, Sara, White, Jacqueline K., Wood, Joshua A., Murray, Stephen A., Heaney, Jason D., Nutter, Lauryl M. J.

“…The International Mouse Phenotyping Consortium (IMPC) systematically produces and phenotypes mouse lines with presumptive null mutations to provide insight…”
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Genetic Vulnerabilities of DNMT3AR882H in Myeloid Malignancies by Gozdecka, Malgorzata, Dudek, Monika, Tzelepis, Konstantinos, Damaskou, Aristi, Baskar, Vijay, Wright, Penny, Duddy, Graham, Meduri, Eshwar, Mazan, Milena, Yusa, Kosuke, Huntly, Brian J.P., Vassiliou, George S.

“…Mutations affecting the gene for the de novo DNA Methyltransferase 3A (DNMT3A) are the most common drivers of clonal hematopoiesis (CH) and amongst the most…”
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Genome-wide screening reveals the genetic basis of mammalian embryonic eye development by Chee, Justine M, Lanoue, Louise, Clary, Dave, Higgins, Kendall, Bower, Lynette, Flenniken, Ann, Guo, Ruolin, Adams, David J, Bosch, Fatima, Braun, Robert E, Brown, Steve D M, Chin, H-J Genie, Dickinson, Mary E, Hsu, Chih-Wei, Dobbie, Michael, Gao, Xiang, Galande, Sanjeev, Grobler, Anne, Heaney, Jason D, Herault, Yann, de Angelis, Martin Hrabe, Mammano, Fabio, Nutter, Lauryl M J, Parkinson, Helen, Qin, Chuan, Shiroishi, Toshi, Sedlacek, Radislav, Seong, J-K, Xu, Ying, Brooks, Brian, McKerlie, Colin, Lloyd, K C Kent, Westerberg, Henrik, Moshiri, Ala

“…Microphthalmia, anophthalmia, and coloboma (MAC) spectrum disease encompasses a group of eye malformations which play a role in childhood visual impairment…”
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Targeting Apoptosis Signalling Kinase-1 by Newton, Victoria L, Ali, Sumia, Duddy, Graham, Whitmarsh, Alan J, Gardiner, Natalie J

“…Apoptosis signal-regulating kinase-1 (ASK1) is a mitogen-activated protein 3 kinase (MAPKKK/MAP3K) which lies upstream of the stress-activated MAPKs, JNK and…”
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High-throughput discovery of genetic determinants of circadian misalignment by Zhang, Tao, Xie, Pancheng, Dong, Yingying, Liu, Zhiwei, Zhou, Fei, Pan, Dejing, Huang, Zhengyun, Zhai, Qiaocheng, Gu, Yue, Wu, Qingyu, Tanaka, Nobuhiko, Obata, Yuichi, Bradley, Allan, Lelliott, Christopher J, Nutter, Lauryl M J, McKerlie, Colin, Flenniken, Ann M, Champy, Marie-France, Sorg, Tania, Herault, Yann, Angelis, Martin Hrabe De, Durner, Valerie Gailus, Mallon, Ann-Marie, Brown, Steve D M, Meehan, Terry, Parkinson, Helen E, Smedley, Damian, Lloyd, K C Kent, Yan, Jun, Gao, Xiang, Seong, Je Kyung, Wang, Chi-Kuang Leo, Sedlacek, Radislav, Liu, Yi, Rozman, Jan, Yang, Ling, Xu, Ying

“…Circadian systems provide a fitness advantage to organisms by allowing them to adapt to daily changes of environmental cues, such as light/dark cycles. The…”
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Molecular and pharmacological characterization of genes encoding urotensin‐II peptides and their cognate G‐protein‐coupled receptors from the mouse and monkey by Elshourbagy, Nabil A., Douglas, Stephen A., Shabon, Usman, Harrison, Stephen, Duddy, Graham, Sechler, Jan L., Ao, Zhaohui, Maleeff, Beverly E., Naselsky, Diane, Disa, Jyoti, Aiyar, Nambi V.

“…Urotensin‐II (U‐II) and its receptor (UT) represent novel therapeutic targets for management of a variety of cardiovascular diseases. To test such hypothesis,…”
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Serum and glucocorticoid‐regulated kinase mediates hypertension and end organ damage in DOCA‐salt hypertension by Schnackenberg, Christine G., Costell, Melissa H., Hoang, Bao, Duddy, Graham, Willette, Robert N.

“…Abstract only Serum and glucocorticoid‐regulated kinase 1 (SGK1) plays an important role in mediating mineralocorticoid receptor stimulated sodium…”
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Characterisation of a K390R ITK Kinase Dead Transgenic Mouse - Implications for ITK as a Therapeutic Target: e107490 by Deakin, Angela, Duddy, Graham, Wilson, Steve, Harrison, Steve, Latcham, Judi, Fulleylove, Mick, Fung, Sylvia, Smith, Jason, Pedrick, Mike, McKevitt, Tom

“…Interleukin-2 inducible tyrosine kinase (ITK) is expressed in T cells and plays a critical role in signalling through the T cell receptor. Evidence, mainly…”
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Compensatory role for Sgk2 mediated sodium reabsorption during salt deprivation in Sgk1 knockout mice by Schnackenberg, Christine G, Costell, Melissa H., Bernard, Roberta E., Minuti, Kristine K., Grygielko, Eugene T., Parsons, Michael J., Laping, Nicholas J., Duddy, Graham

“…The purpose of this study was to investigate the role of Sgk2 in the regulation of salt and water homeostasis. Kidney function and expression of Sgk1, Sgk2,…”
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