Search Results - "Dudanova, Irina"

Biosensors for Studying Neuronal Proteostasis by Dudanova, Irina

“…Cellular health depends on the integrity and functionality of the proteome. Each cell is equipped with a protein quality control machinery that maintains…”
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Cortical and Striatal Circuits in Huntington's Disease by Blumenstock, Sonja, Dudanova, Irina

“…Huntington's disease (HD) is a hereditary neurodegenerative disorder that typically manifests in midlife with motor, cognitive, and/or psychiatric symptoms…”
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In situ architecture of neuronal α-Synuclein inclusions by Trinkaus, Victoria A., Riera-Tur, Irene, Martínez-Sánchez, Antonio, Bäuerlein, Felix J. B., Guo, Qiang, Arzberger, Thomas, Baumeister, Wolfgang, Dudanova, Irina, Hipp, Mark S., Hartl, F. Ulrich, Fernández-Busnadiego, Rubén

“…The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. α-Syn inclusions were long…”
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The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model by Yuste-Checa, Patricia, Trinkaus, Victoria A., Riera-Tur, Irene, Imamoglu, Rahmi, Schaller, Theresa F., Wang, Huping, Dudanova, Irina, Hipp, Mark S., Bracher, Andreas, Hartl, F. Ulrich

“…Spreading of aggregate pathology across brain regions acts as a driver of disease progression in Tau-related neurodegeneration, including Alzheimer’s disease…”
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In Situ Architecture and Cellular Interactions of PolyQ Inclusions by Bäuerlein, Felix J.B., Saha, Itika, Mishra, Archana, Kalemanov, Maria, Martínez-Sánchez, Antonio, Klein, Rüdiger, Dudanova, Irina, Hipp, Mark S., Hartl, F. Ulrich, Baumeister, Wolfgang, Fernández-Busnadiego, Rubén

“…Expression of many disease-related aggregation-prone proteins results in cytotoxicity and the formation of large intracellular inclusion bodies. To gain…”
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Cortical circuit alterations precede motor impairments in Huntington’s disease mice by Burgold, Johanna, Schulz-Trieglaff, Elena Katharina, Voelkl, Kerstin, Gutiérrez-Ángel, Sara, Bader, Jakob Maximilian, Hosp, Fabian, Mann, Matthias, Arzberger, Thomas, Klein, Rüdiger, Liebscher, Sabine, Dudanova, Irina

“…Huntington’s disease (HD) is a devastating hereditary movement disorder, characterized by degeneration of neurons in the striatum and cortex. Studies in human…”
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The composition of EphB2 clusters determines the strength in the cellular repulsion response by Schaupp, Andreas, Sabet, Ola, Dudanova, Irina, Ponserre, Marion, Bastiaens, Philippe, Klein, Rüdiger

“…Trans interactions of erythropoietin-producing human hepatocellular (Eph) receptors with their membrane-bound ephrin ligands generate higher-order clusters…”
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Spatiotemporal Proteomic Profiling of Huntington’s Disease Inclusions Reveals Widespread Loss of Protein Function by Hosp, Fabian, Gutiérrez-Ángel, Sara, Schaefer, Martin H., Cox, Jürgen, Meissner, Felix, Hipp, Mark S., Hartl, F.-Ulrich, Klein, Rüdiger, Dudanova, Irina, Mann, Matthias

“…Aggregation of polyglutamine-expanded huntingtin exon 1 (HttEx1) in Huntington’s disease (HD) proceeds from soluble oligomers to late-stage inclusions. The…”
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The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system by Saha, Itika, Yuste-Checa, Patricia, Da Silva Padilha, Miguel, Guo, Qiang, Körner, Roman, Holthusen, Hauke, Trinkaus, Victoria A., Dudanova, Irina, Fernández-Busnadiego, Rubén, Baumeister, Wolfgang, Sanders, David W., Gautam, Saurabh, Diamond, Marc I., Hartl, F. Ulrich, Hipp, Mark S.

“…Amyloid-like aggregates of the microtubule-associated protein Tau are associated with several neurodegenerative disorders including Alzheimer’s disease. The…”
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GDNF Acts as a Chemoattractant to Support ephrinA-Induced Repulsion of Limb Motor Axons by Dudanova, Irina, Gatto, Graziana, Klein, Rüdiger

“…Despite the abundance of guidance cues in vertebrate nervous systems, little is known about cooperation between them [1–3]. Motor axons of the lateral motor…”
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Distinct histological alterations of cortical interneuron types in mouse models of Huntington’s disease by Voelkl, Kerstin, Schulz-Trieglaff, Elena Katharina, Klein, Rüdiger, Dudanova, Irina

“…Huntington’s disease (HD) is a debilitating hereditary motor disorder caused by an expansion of the CAG triplet repeat in the Huntingtin gene. HD causes…”
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Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling by Gatto, Graziana, Dudanova, Irina, Suetterlin, Philipp, Davies, Alun M, Drescher, Uwe, Bixby, John L, Klein, Rüdiger

“…Axonal branches of the trigeminal ganglion (TG) display characteristic growth and arborization patterns during development. Subsets of TG neurons express…”
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Genetic targeting of NRXN2 in mice unveils role in excitatory cortical synapse function and social behaviors by Born, Gesche, Grayton, Hannah M, Langhorst, Hanna, Dudanova, Irina, Rohlmann, Astrid, Woodward, Benjamin W, Collier, David A, Fernandes, Cathy, Missler, Markus

“…Human genetics has identified rare copy number variations and deleterious mutations for all neurexin genes (NRXN1-3) in patients with neurodevelopmental…”
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Balancing neuronal circuits by Blumenstock, Sonja, Dudanova, Irina

“…Correcting synaptic defects in development delays Huntington’s disease symptoms in older mice Neurodegenerative diseases are associated with old age. However,…”
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Integration of guidance cues: parallel signaling and crosstalk by Dudanova, Irina, Klein, Rüdiger

“…Growing axons are exposed to various guidance cues en route to their targets. Although many guidance molecules have been identified and their effects on axon…”
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The Axon's Balancing Act:cis- andtrans-Interactions between Ephs and Ephrins by Dudanova, Irina, Klein, Rüdiger

“…Ephrin ligands are known to be coexpressed with Eph receptors in certain populations of axons. In this issue ofNeuron, Kao and Kania demonstrate the importance…”
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The Axon's Balancing Act: cis- and trans-Interactions between Ephs and Ephrins by Dudanova, Irina, Klein, Rüdiger

“…Ephrin ligands are known to be coexpressed with Eph receptors in certain populations of axons. In this issue of Neuron, Kao and Kania demonstrate the…”
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Fluc‐EGFP reporter mice reveal differential alterations of neuronal proteostasis in aging and disease by Blumenstock, Sonja, Schulz‐Trieglaff, Elena Katharina, Voelkl, Kerstin, Bolender, Anna‐Lena, Lapios, Paul, Lindner, Jana, Hipp, Mark S, Hartl, F Ulrich, Klein, Rüdiger, Dudanova, Irina

“…The cellular protein quality control machinery is important for preventing protein misfolding and aggregation. Declining protein homeostasis (proteostasis) is…”
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Genetic evidence for a contribution of EphA:ephrinA reverse signaling to motor axon guidance by Dudanova, Irina, Kao, Tzu-Jen, Herrmann, Julia E, Zheng, Binhai, Kania, Artur, Klein, Rüdiger

“…Repulsive Eph forward signaling from limb-derived ephrins guides the axons of lateral motor column (LMC) motor neurons. LMC axons also express ephrinAs, while…”
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Neuroprotective effects of hepatoma-derived growth factor in models of Huntington's disease by Voelkl, Kerstin, Gutiérrez-Ángel, Sara, Keeling, Sophie, Koyuncu, Seda, da Silva Padilha, Miguel, Feigenbutz, Dennis, Arzberger, Thomas, Vilchez, David, Klein, Rüdiger, Dudanova, Irina

“…Huntington's disease (HD) is a movement disorder caused by a mutation in the Huntingtin gene that leads to severe neurodegeneration. Molecular mechanisms of HD…”
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