Search Results - "Dudakov, Jarrod A."

When the Damage Is Done: Injury and Repair in Thymus Function by Kinsella, Sinéad, Dudakov, Jarrod A

“…Even though the thymus is exquisitely sensitive to acute insults like infection, shock, or common cancer therapies such as cytoreductive chemo- or…”
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Interleukin-22: Immunobiology and Pathology by Dudakov, Jarrod A, Hanash, Alan M, van den Brink, Marcel R.M

“…Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T helper (Th) 17 cells, γδ T cells, NKT cells, and newly described…”
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Thymus: the next (re)generation by Chaudhry, Mohammed S., Velardi, Enrico, Dudakov, Jarrod A., van den Brink, Marcel R. M.

“…Summary As the primary site of T‐cell development, the thymus plays a key role in the generation of a strong yet self‐tolerant adaptive immune response,…”
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Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation by Jenq, Robert R, Ubeda, Carles, Taur, Ying, Menezes, Clarissa C, Khanin, Raya, Dudakov, Jarrod A, Liu, Chen, West, Mallory L, Singer, Natalie V, Equinda, Michele J, Gobourne, Asia, Lipuma, Lauren, Young, Lauren F, Smith, Odette M, Ghosh, Arnab, Hanash, Alan M, Goldberg, Jenna D, Aoyama, Kazutoshi, Blazar, Bruce R, Pamer, Eric G, van den Brink, Marcel R M

“…Despite a growing understanding of the link between intestinal inflammation and resident gut microbes, longitudinal studies of human flora before initial onset…”
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Interleukin-22 Drives Endogenous Thymic Regeneration in Mice by Dudakov, Jarrod A., Hanash, Alan M., Jenq, Robert R., Young, Lauren F., Ghosh, Arnab, Singer, Natalie V., West, Mallory L., Smith, Odette M., Holland, Amanda M., Tsai, Jennifer J., Boyd, Richard L., van den Brink, Marcel R. M.

“…Endogenous thymic regeneration is a crucial function that allows for renewal of immune competence after stress, infection, or immunodepletion. However, the…”
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RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury by Fischer, Julius C, Bscheider, Michael, Eisenkolb, Gabriel, Lin, Chia-Ching, Wintges, Alexander, Otten, Vera, Lindemans, Caroline A, Heidegger, Simon, Rudelius, Martina, Monette, Sébastien, Porosnicu Rodriguez, Kori A, Calafiore, Marco, Liebermann, Sophie, Liu, Chen, Lienenklaus, Stefan, Weiss, Siegfried, Kalinke, Ulrich, Ruland, Jürgen, Peschel, Christian, Shono, Yusuke, Docampo, Melissa, Velardi, Enrico, Jenq, Robert R, Hanash, Alan M, Dudakov, Jarrod A, Haas, Tobias, van den Brink, Marcel R M, Poeck, Hendrik

“…The molecular pathways that regulate the tissue repair function of type I interferon (IFN-I) during acute tissue damage are poorly understood. We describe a…”
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Loss of thymic innate lymphoid cells leads to impaired thymopoiesis in experimental graft-versus-host disease by Dudakov, Jarrod A., Mertelsmann, Anna M., O'Connor, Margaret H., Jenq, Robert R., Velardi, Enrico, Young, Lauren F., Smith, Odette M., Boyd, Richard L., van den Brink, Marcel R.M., Hanash, Alan M.

“…Graft-versus-host disease (GVHD) and posttransplant immunodeficiency are frequently related complications of allogeneic hematopoietic transplantation…”
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Sex steroid blockade enhances thymopoiesis by modulating Notch signaling by Velardi, Enrico, Tsai, Jennifer J, Holland, Amanda M, Wertheimer, Tobias, Yu, Vionnie W C, Zakrzewski, Johannes L, Tuckett, Andrea Z, Singer, Natalie V, West, Mallory L, Smith, Odette M, Young, Lauren F, Kreines, Fabiana M, Levy, Emily R, Boyd, Richard L, Scadden, David T, Dudakov, Jarrod A, van den Brink, Marcel R M

“…Paradoxical to its importance for generating a diverse T cell repertoire, thymic function progressively declines throughout life. This process has been at…”
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Attenuation of apoptotic cell detection triggers thymic regeneration after damage by Kinsella, Sinéad, Evandy, Cindy A., Cooper, Kirsten, Iovino, Lorenzo, deRoos, Paul C., Hopwo, Kayla S., Granadier, David W., Smith, Colton W., Rafii, Shahin, Dudakov, Jarrod A.

“…The thymus, which is the primary site of T cell development, is particularly sensitive to insult but also has a remarkable capacity for repair. However, the…”
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Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration by Wertheimer, Tobias, Velardi, Enrico, Tsai, Jennifer, Cooper, Kirsten, Xiao, Shiyun, Kloss, Christopher C, Ottmüller, Katja J, Mokhtari, Zeinab, Brede, Christian, deRoos, Paul, Kinsella, Sinéad, Palikuqi, Brisa, Ginsberg, Michael, Young, Lauren F, Kreines, Fabiana, Lieberman, Sophia R, Lazrak, Amina, Guo, Peipei, Malard, Florent, Smith, Odette M, Shono, Yusuke, Jenq, Robert R, Hanash, Alan M, Nolan, Daniel J, Butler, Jason M, Beilhack, Andreas, Manley, Nancy R, Rafii, Shahin, Dudakov, Jarrod A, van den Brink, Marcel R M

“…The thymus is not only extremely sensitive to damage but also has a remarkable ability to repair itself. However, the mechanisms underlying this endogenous…”
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The central nervous system is a target of acute graft versus host disease in mice by Hartrampf, Steffen, Dudakov, Jarrod A., Johnson, Linda K., Smith, Odette M., Tsai, Jennifer, Singer, Natalie V., West, Mallory L., Hanash, Alan M., Albert, Michael H., Liu, Bingfang, Toth, Miklos, van den Brink, Marcel R.M.

“…Despite significant advances in prevention and management, graft versus host disease (GVHD) is still a leading complication after allogeneic hematopoietic stem…”
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Clinical strategies to enhance thymic recovery after allogeneic hematopoietic stem cell transplantation by Velardi, Enrico, Dudakov, Jarrod A, van den Brink, Marcel R.M

“…Abstract The thymus is particularly sensitive to injury caused by cytoreductive chemo- or radiation therapy, shock, infection and graft versus host disease…”
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Enhanced Hematopoietic Stem Cell Function Mediates Immune Regeneration following Sex Steroid Blockade by Khong, Danika M., Dudakov, Jarrod A., Hammett, Maree V., Jurblum, Marc I., Khong, Sacha M.L., Goldberg, Gabrielle L., Ueno, Tomoo, Spyroglou, Lisa, Young, Lauren F., van den Brink, Marcel R.M., Boyd, Richard L., Chidgey, Ann P.

“…Mechanisms underlying age-related defects within lymphoid-lineages remain poorly understood. We previously reported that sex steroid ablation (SSA) induced…”
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Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting by Srivastava, Shivani, Salter, Alexander I., Liggitt, Denny, Yechan-Gunja, Sushma, Sarvothama, Megha, Cooper, Kirsten, Smythe, Kimberly S., Dudakov, Jarrod A., Pierce, Robert H., Rader, Christoph, Riddell, Stanley R.

“…Many potential targets for CAR-T cells in solid tumors are expressed in some normal tissues, raising concern for off-tumor toxicity. Following lymphodepletion,…”
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Feeling at home: Identifying a human thymic epithelial progenitor cell niche by Acenas, Dante V., Dudakov, Jarrod A.

“…T cell development relies on a supportive epithelial microenvironment. Embryonic and postnatal epithelial progenitors have been identified in mice, but not…”
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Dynamics of thymus function and T cell receptor repertoire breadth in health and disease by Granadier, David, Iovino, Lorenzo, Kinsella, Sinéad, Dudakov, Jarrod A.

“…T cell recognition of unknown antigens relies on the tremendous diversity of the T cell receptor (TCR) repertoire; generation of which can only occur in the…”
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Feeding the fire: the role of defective bone marrow function in exacerbating thymic involution by Dudakov, Jarrod A, Khong, Danika M.P, Boyd, Richard L, Chidgey, Ann P

“…Most of the steps of lymphopoiesis have been elucidated but contentious issues remain, particularly regarding the identity and function of the earliest…”
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Thymic involution: where endocrinology meets immunology by Calder, Adrienne E, Hince, Melanie N, Dudakov, Jarrod A, Chidgey, Ann P, Boyd, Richard L

“…The decline in immune function with aging represents a major clinical challenge in many disease conditions. It is manifest in many parameters but is…”
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Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice by Shono, Yusuke, Docampo, Melissa D, Peled, Jonathan U, Perobelli, Suelen M, Velardi, Enrico, Tsai, Jennifer J, Slingerland, Ann E, Smith, Odette M, Young, Lauren F, Gupta, Jyotsna, Lieberman, Sophia R, Jay, Hillary V, Ahr, Katya F, Porosnicu Rodriguez, Kori A, Xu, Ke, Calarfiore, Marco, Poeck, Hendrik, Caballero, Silvia, Devlin, Sean M, Rapaport, Franck, Dudakov, Jarrod A, Hanash, Alan M, Gyurkocza, Boglarka, Murphy, George F, Gomes, Camilla, Liu, Chen, Moss, Eli L, Falconer, Shannon B, Bhatt, Ami S, Taur, Ying, Pamer, Eric G, van den Brink, Marcel R M, Jenq, Robert R

“…Intestinal bacteria may modulate the risk of infection and graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation…”
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Greater than the sum of their parts: Combination strategies for immune regeneration following allogeneic hematopoietic stem cell transplantation by Dudakov, Jarrod A., Research Fellow, van den Brink, Marcel R.M

“…Cytoreductive conditioning regimes designed to allow for successful allogeneic hematopoietic stem cell transplantation (allo-HSCT) paradoxically are also…”
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