Search Results - "Duda, David"

Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis by Ordureau, Alban, Sarraf, Shireen A., Duda, David M., Heo, Jin-Mi, Jedrychowski, Mark P., Sviderskiy, Vladislav O., Olszewski, Jennifer L., Koerber, James T., Xie, Tiao, Beausoleil, Sean A., Wells, James A., Gygi, Steven P., Schulman, Brenda A., Harper, J. Wade

“…Phosphorylation is often used to promote protein ubiquitylation, yet we rarely understand quantitatively how ligase activation and ubiquitin (UB) chain…”
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Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy by Ordureau, Alban, Heo, Jin-Mi, Duda, David M., Paulo, Joao A., Olszewski, Jennifer L., Yanishevski, David, Rinehart, Jesse, Schulman, Brenda A., Harper, J. Wade

“…Significance PINK1 protein kinase and PARKIN UB ligase are mutated in inherited forms of Parkinson’s disease and several cancers. Thus, it is of great…”
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Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation by Scott, Daniel C., Rhee, David Y., Duda, David M., Kelsall, Ian R., Olszewski, Jennifer L., Paulo, Joao A., de Jong, Annemieke, Ovaa, Huib, Alpi, Arno F., Harper, J. Wade, Schulman, Brenda A.

“…Hundreds of human cullin-RING E3 ligases (CRLs) modify thousands of proteins with ubiquitin (UB) to achieve vast regulation. Current dogma posits that CRLs…”
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Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism by Duda, David M., Olszewski, Jennifer L., Schuermann, Jonathan P., Kurinov, Igor, Miller, Darcie J., Nourse, Amanda, Alpi, Arno F., Schulman, Brenda A.

“…A distinct mechanism for ubiquitin (Ub) ligation has recently been proposed for the RING1-IBR-RING2 (RBR) family of E3s: an N-terminal RING1 domain recruits a…”
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Structure of a Glomulin-RBX1-CUL1 Complex: Inhibition of a RING E3 Ligase through Masking of Its E2-Binding Surface by Duda, David M., Olszewski, Jennifer L., Tron, Adriana E., Hammel, Michal, Lambert, Lester J., Waddell, M. Brett, Mittag, Tanja, DeCaprio, James A., Schulman, Brenda A.

“…The approximately 300 human cullin-RING ligases (CRLs) are multisubunit E3s in which a RING protein, either RBX1 or RBX2, recruits an E2 to catalyze…”
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Activity-based profiling of cullin–RING E3 networks by conformation-specific probes by Henneberg, Lukas T., Singh, Jaspal, Duda, David M., Baek, Kheewoong, Yanishevski, David, Murray, Peter J., Mann, Matthias, Sidhu, Sachdev S., Schulman, Brenda A.

“…The cullin–RING ubiquitin ligase (CRL) network comprises over 300 unique complexes that switch from inactive to activated conformations upon site-specific…”
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Structural regulation of cullin-RING ubiquitin ligase complexes by Duda, David M, Scott, Daniel C, Calabrese, Matthew F, Zimmerman, Erik S, Zheng, Ning, Schulman, Brenda A

“…▶ Recent structural studies have revealed numerous ways in which CRL E3 ligase activities are controlled, including: ▶ Mechanisms of multimodal CRL E3 ligase…”
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Impact of COVID‐19‐Related Air Traffic Reductions on the Coverage and Radiative Effects of Linear Persistent Contrails Over Conterminous United States and Surrounding Oceanic Routes by Duda, David P., Smith, William L., Bedka, Sarah, Spangenberg, Douglas, Chee, Thad, Minnis, Patrick

“…The radiative effects of the large‐scale air traffic slowdown during April and May 2020 due to the international response to the COVID‐19 pandemic are…”
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Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation by Duda, David M., Borg, Laura A., Scott, Daniel C., Hunt, Harold W., Hammel, Michal, Schulman, Brenda A.

“…Cullin-RING ligases (CRLs) comprise the largest ubiquitin E3 subclass, in which a central cullin subunit links a substrate-binding adaptor with an E2-binding…”
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Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases by Zhuang, Min, Calabrese, Matthew F., Liu, Jiang, Waddell, M. Brett, Nourse, Amanda, Hammel, Michal, Miller, Darcie J., Walden, Helen, Duda, David M., Seyedin, Steven N., Hoggard, Timothy, Harper, J. Wade, White, Kevin P., Schulman, Brenda A.

“…In the largest E3 ligase subfamily, Cul3 binds a BTB domain, and an associated protein-interaction domain such as MATH recruits substrates for ubiquitination…”
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TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes by Kelsall, Ian R, Duda, David M, Olszewski, Jennifer L, Hofmann, Kay, Knebel, Axel, Langevin, Frédéric, Wood, Nicola, Wightman, Melanie, Schulman, Brenda A, Alpi, Arno F

“…RING (Really Interesting New Gene)‐in‐between‐RING (RBR) enzymes are a distinct class of E3 ubiquitin ligases possessing a cluster of three zinc‐binding…”
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The Glomuvenous Malformation Protein Glomulin Binds Rbx1 and Regulates Cullin RING Ligase-Mediated Turnover of Fbw7 by Tron, Adriana E., Arai, Takehiro, Duda, David M., Kuwabara, Hiroshi, Olszewski, Jennifer L., Fujiwara, Yuko, Bahamon, Brittany N., Signoretti, Sabina, Schulman, Brenda A., DeCaprio, James A.

“…Fbw7, a substrate receptor for Cul1-RING-ligase (CRL1), facilitates the ubiquitination and degradation of several proteins, including Cyclin E and c-Myc. In…”
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Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1 by Dove, Katja K., Olszewski, Jennifer L., Martino, Luigi, Duda, David M., Wu, Xiaoli S., Miller, Darcie J., Reiter, Katherine H., Rittinger, Katrin, Schulman, Brenda A., Klevit, Rachel E.

“…RING-between-RING (RBR) E3s contain RING1 domains that are structurally similar yet mechanistically distinct from canonical RING domains. Both types of E3 bind…”
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Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7–Atg3 and Atg7–Atg10 structures by Kaiser, Stephen E, Mao, Kai, Taherbhoy, Asad M, Yu, Shanshan, Olszewski, Jennifer L, Duda, David M, Kurinov, Igor, Deng, Alan, Fenn, Timothy D, Klionsky, Daniel J, Schulman, Brenda A

“…An early step in the autophagy process is the conjugation of the ubiquitin-like proteins (UBLs) Atg8 and Atg12 to their targets. Structural and functional…”
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Pathogenic bacteria target NEDD8-conjugated cullins to hijack host-cell signaling pathways by Jubelin, Grégory, Taieb, Frédéric, Duda, David M, Hsu, Yun, Samba-Louaka, Ascel, Nobe, Rika, Penary, Marie, Watrin, Claude, Nougayrède, Jean-Philippe, Schulman, Brenda A, Stebbins, C Erec, Oswald, Eric

“…The cycle inhibiting factors (Cif), produced by pathogenic bacteria isolated from vertebrates and invertebrates, belong to a family of molecules called…”
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Site‐directed integration of exogenous DNA into the soybean genome by LbCas12a fused to a plant viral HUH endonuclease by Nagy, Ervin D., Kuehn, Rosemarie, Wang, Dafu, Shrawat, Ashok, Duda, David M., Groat, Jeanna R., Yang, Peizhen, Beach, Steven, Zhang, Yuanji, Rymarquis, Linda, Carter, Sharina L., Gaeta, Robert T., Gilbertson, Larry A.

“…SUMMARY High efficiency site‐directed chromosomal integration of exogenous DNA in plants remains a challenge despite recent advances in genome editing…”
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A Dual E3 Mechanism for Rub1 Ligation to Cdc53 by Scott, Daniel C., Monda, Julie K., Grace, Christy R.R., Duda, David M., Kriwacki, Richard W., Kurz, Thimo, Schulman, Brenda A.

“…In ubiquitin-like protein (UBL) cascades, a thioester-linked E2∼UBL complex typically interacts with an E3 enzyme for UBL transfer to the target. Here we…”
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E2-RING Expansion of the NEDD8 Cascade Confers Specificity to Cullin Modification by Huang, Danny T., Ayrault, Olivier, Hunt, Harold W., Taherbhoy, Asad M., Duda, David M., Scott, Daniel C., Borg, Laura A., Neale, Geoffrey, Murray, Peter J., Roussel, Martine F., Schulman, Brenda A.

“…Ubiquitin and ubiquitin-like proteins (UBLs) are directed to targets by cascades of E1, E2, and E3 enzymes. The largest ubiquitin E3 subclass consists of…”
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Estimation of 2006 Northern Hemisphere contrail coverage using MODIS data by Duda, David P., Minnis, Patrick, Khlopenkov, Konstantin, Chee, Thad L., Boeke, Robyn

“…A modified automated contrail detection algorithm (CDA) using five infrared channels available from the Moderate Resolution Imaging Spectrometer onboard the…”
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Structural and functional insights into the first Bacillus thuringiensis vegetative insecticidal protein of the Vpb4 fold, active against western corn rootworm by Kouadio, Jean-Louis, Zheng, Meiying, Aikins, Michael, Duda, David, Duff, Stephen, Chen, Danqi, Zhang, Jun, Milligan, Jason, Taylor, Christina, Mamanella, Patricia, Rydel, Timothy, Kessenich, Colton, Panosian, Timothy, Yin, Yong, Moar, William, Giddings, Kara, Park, Yoonseong, Jerga, Agoston, Haas, Jeffrey

“…The western corn rootworm (WCR), Diabrotica virgifera virgifera LeConte, is a major maize pest in the United States causing significant economic loss. The…”
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