Search Results - "Ducret, Axel"

Assay format diversity in pre-clinical immunogenicity risk assessment: Toward a possible harmonization of antigenicity assays by Ducret, Axel, Ackaert, Chloé, Bessa, Juliana, Bunce, Campbell, Hickling, Timothy, Jawa, Vibha, Kroenke, Mark A., Lamberth, Kasper, Manin, Anaïs, Penny, Hweixian L., Smith, Noel, Terszowski, Grzegorz, Tourdot, Sophie, Spindeldreher, Sebastian

“…A major impediment to successful use of therapeutic protein drugs is their ability to induce anti-drug antibodies (ADA) that can alter treatment efficacy and…”
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Development and characterization of dendritic cell internalization and activation assays contributing to the immunogenicity risk evaluation of biotherapeutics by Siegel, Michel, Padamsey, Aman, Bolender, Anna-Lena, Hargreaves, Patrick, Fraidling, Johannes, Ducret, Axel, Hartman, Katharina, Looney, Cary M, Bertinetti-Lapatki, Cristina, Rohr, Olivier, Hickling, Timothy P, Kraft, Thomas E, Marban-Doran, Céline

“…Immunogenicity refers to the ability of a substance, such as a therapeutic drug, to elicit an immune response. While beneficial in vaccine development,…”
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Internalization of therapeutic antibodies into dendritic cells as a risk factor for immunogenicity by Siegel, Michel, Bolender, Anna-Lena, Ducret, Axel, Fraidling, Johannes, Hartman, Katharina, Looney, Cary M, Rohr, Olivier, Hickling, Timothy P, Kettenberger, Hubert, Lechmann, Martin, Marban-Doran, Céline, Kraft, Thomas E

“…Immunogenicity, the unwanted immune response triggered by therapeutic antibodies, poses significant challenges in biotherapeutic development. This response can…”
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Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor by Stahl, Sebastian, Seidl, Ana Rita da Silva Mateus, Ducret, Axel, van Geijtenbeek, Sabine Kux, Michel, Sven, Racek, Tomas, Birzele, Fabian, Haas, Alexander K., Rueger, Ruediger, Gerg, Michael, Niederfellner, Gerhard, Pastan, Ira, Brinkmann, Ulrich

“…The diphthamide on human eukaryotic translation elongation factor 2 (eEF2) is the target of ADP ribosylating diphtheria toxin (DT) andPseudomonasexotoxin A…”
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Applications of mass spectrometry for quantitative protein analysis in formalin-fixed paraffin-embedded tissues by Steiner, Carine, Ducret, Axel, Tille, Jean-Christophe, Thomas, Marlene, McKee, Thomas A., Rubbia-Brandt, Laura, Scherl, Alexander, Lescuyer, Pierre, Cutler, Paul

“…Proteomic analysis of tissues has advanced in recent years as instruments and methodologies have evolved. The ability to retrieve peptides from formalin‐fixed…”
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Impairment of Multiple Mitochondrial Energy Metabolism Pathways in the Heart of Chagas Disease Cardiomyopathy Patients by Teixeira, Priscila Camillo, Ducret, Axel, Langen, Hanno, Nogoceke, Everson, Santos, Ronaldo Honorato Barros, Silva Nunes, João Paulo, Benvenuti, Luiz, Levy, Debora, Bydlowski, Sergio Paulo, Bocchi, Edimar Alcides, Kuramoto Takara, Andréia, Fiorelli, Alfredo Inácio, Stolf, Noedir Antonio, Pomeranzeff, Pablo, Chevillard, Christophe, Kalil, Jorge, Cunha-Neto, Edecio

“…Chagas disease cardiomyopathy (CCC) is an inflammatory dilated cardiomyopathy occurring in 30% of the 6 million infected with the protozoan in Latin America…”
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Expanding the MAPPs Assay to Accommodate MHC-II Pan Receptors for Improved Predictability of Potential T Cell Epitopes by Hartman, Katharina, Steiner, Guido, Siegel, Michel, Looney, Cary M, Hickling, Timothy P, Bray-French, Katharine, Springer, Sebastian, Marban-Doran, Céline, Ducret, Axel

“…A critical step in the immunogenicity cascade is attributed to human leukocyte antigen (HLA) II presentation triggering T cell immune responses. The liquid…”
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Validation of a Dendritic Cell and CD4+ T Cell Restimulation Assay Contributing to the Immunogenicity Risk Evaluation of Biotherapeutics by Siegel, Michel, Steiner, Guido, Franssen, Linnea C, Carratu, Francesca, Herron, James, Hartman, Katharina, Looney, Cary M, Ducret, Axel, Bray-French, Katharine, Rohr, Olivier, Hickling, Timothy P, Smith, Noel, Marban-Doran, Céline

“…Immunogenicity, defined as the ability to provoke an immune response, can be either wanted (i.e., vaccines) or unwanted. The latter refers to an immune…”
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Translation and evaluation of a pre-clinical 5-protein response prediction signature in a breast cancer phase Ib clinical trial by Ducret, Axel, James, Ian, Wilson, Sabine, Feilke, Martina, Tebbe, Andreas, Dybowski, Nikolaj, Elschenbroich, Sarah, Klammer, Martin, Blackler, Adele, Liao, Wei-Li, Tian, Yuan, Friess, Thomas, Bossenmaier, Birgit, Dietmann, Gabriele, Schaab, Christoph, Hembrough, Todd, Ceppi, Maurizio

“…Human protein biomarker discovery relies heavily on pre-clinical models, in particular established cell lines and patient-derived xenografts, but confirmation…”
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High throughput protein characterization by automated reverse‐phase chromatography/electrospray tandem mass spectrometry by Ducret, Axel, Oostveen, Inge Van, Eng, Jimmy K., Yates, John R., Aebersold, Ruedi

“…We describe an integrated workstation for the automated, high‐throughput, and conclusive identification of proteins by reverse‐phase chromatography…”
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Automated sample preparation platform for mass spectrometry-based plasma proteomics and biomarker discovery by Guryča, Vilém, Roeder, Daniel, Piraino, Paolo, Lamerz, Jens, Ducret, Axel, Langen, Hanno, Cutler, Paul

“…The identification of novel biomarkers from human plasma remains a critical need in order to develop and monitor drug therapies for nearly all disease areas…”
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Protein identification by solid phase microextraction-capillary zone electrophoresis-microelectrospray-tandem mass spectrometry by Figeys, Daniel, Ducret, Axel, Yates, John R, Aebersold, Ruedi

“…We describe an analytical system for the rapid identification of proteins by correlation of tandem mass spectra with protein sequence databases. The system…”
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Relative Quantification of Proteins in Formalin-Fixed Paraffin-Embedded Breast Cancer Tissue Using Multiplexed Mass Spectrometry Assays by Steiner, Carine, Lescuyer, Pierre, Cutler, Paul, Tille, Jean-Christophe, Ducret, Axel

“…The identification of clinically relevant biomarkers represents an important challenge in oncology. This problem can be addressed with biomarker discovery and…”
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Membrane Amine Oxidase Cloning and Identification as a Major Protein in the Adipocyte Plasma Membrane by Morris, N J, Ducret, A, Aebersold, R, Ross, S A, Keller, S R, Lienhard, G E

“…A 97-kDa protein present in the glucose transporter (GLUT4 isotype)-containing vesicles from rat adipocytes has been isolated, the sequences of two tryptic…”
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Biomarker Discovery by Imaging Mass Spectrometry by Meistermann, Hélène, Norris, Jeremy L., Aerni, Hans-Rudolf, Cornett, Dale S., Friedlein, Arno, Erskine, Annette R., Augustin, Angélique, De Vera Mudry, Maria Cristina, Ruepp, Stefan, Suter, Laura, Langen, Hanno, Caprioli, Richard M., Ducret, Axel

“…Adverse drug effects are often associated with pathological changes in tissue. An accurate depiction of the undesired affected area, possibly supported by…”
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Targeting intracellular WT1 in AML with a novel RMF-peptide-MHC-specific T-cell bispecific antibody by Augsberger, Christian, Hänel, Gerulf, Xu, Wei, Pulko, Vesna, Hanisch, Lydia Jasmin, Augustin, Angelique, Challier, John, Hunt, Katharina, Vick, Binje, Rovatti, Pier Eduardo, Krupka, Christina, Rothe, Maurine, Schönle, Anne, Sam, Johannes, Lezan, Emmanuelle, Ducret, Axel, Ortiz-Franyuti, Daniela, Walz, Antje-Christine, Benz, Jörg, Bujotzek, Alexander, Lichtenegger, Felix S., Gassner, Christian, Carpy, Alejandro, Lyamichev, Victor, Patel, Jigar, Konstandin, Nikola, Tunger, Antje, Schmitz, Marc, von Bergwelt-Baildon, Michael, Spiekermann, Karsten, Vago, Luca, Jeremias, Irmela, Marrer-Berger, Estelle, Umaña, Pablo, Klein, Christian, Subklewe, Marion

“…Antibody-based immunotherapy is a promising strategy for targeting chemoresistant leukemic cells. However, classical antibody-based approaches are restricted…”
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Proteolysis-Targeting Chimeras Enhance T Cell Bispecific Antibody-Driven T Cell Activation and Effector Function through Increased MHC Class I Antigen Presentation in Cancer Cells by Massafra, Vittoria, Tundo, Sofia, Dietzig, Aline, Ducret, Axel, Jost, Christian, Klein, Christian, Kontermann, Roland E., Knoetgen, Hendrik, Steegmaier, Martin, Romagnani, Andrea, Nagel, Yvonne A.

“…Abstract The availability of Ags on the surface of tumor cells is crucial for the efficacy of cancer immunotherapeutic approaches using large molecules, such…”
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Enabling Routine MHC-II-Associated Peptide Proteomics for Risk Assessment of Drug-Induced Immunogenicity by Steiner, Guido, Marban-Doran, Céline, Langer, Jessica, Pimenova, Tatiana, Duran-Pacheco, Gonzalo, Sauter, Denise, Langenkamp, Anja, Solier, Corinne, Singer, Thomas, Bray-French, Katharine, Ducret, Axel

“…Major histocompatibility complex-II (MHC-II)-Associated Peptide Proteomics (MAPPs) is a mass spectrometry-based approach to identify and relatively quantitate…”
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Caspase-Resistant BAP31 Inhibits Fas-Mediated Apoptotic Membrane Fragmentation and Release of Cytochrome cfrom Mitochondria by Nguyen, Mai, Breckenridge, David G., Ducret, Axel, Shore, Gordon C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Correction to “Enabling Routine MHC-II-Associated Peptide Proteomics for Risk Assessment of Drug-Induced Immunogenicity” by Steiner, Guido, Marban-Doran, Céline, Langer, Jessica, Pimenova, Tatiana, Duran-Pacheco, Gonzalo, Sauter, Denise, Langenkamp, Anja, Solier, Corinne, Singer, Thomas, Bray-French, Katharine, Ducret, Axel

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