Search Results - "Ducommun, Serge"

Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function by Mottillo, Emilio P., Desjardins, Eric M., Crane, Justin D., Smith, Brennan K., Green, Alex E., Ducommun, Serge, Henriksen, Tora I., Rebalka, Irena A., Razi, Aida, Sakamoto, Kei, Scheele, Camilla, Kemp, Bruce E., Hawke, Thomas J., Ortega, Joaquin, Granneman, James G., Steinberg, Gregory R.

“…Brown (BAT) and white (WAT) adipose tissues play distinct roles in maintaining whole-body energy homeostasis, and their dysfunction can contribute to…”
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Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate by Ducommun, Serge, Deak, Maria, Sumpton, David, Ford, Rebecca J., Núñez Galindo, Antonio, Kussmann, Martin, Viollet, Benoit, Steinberg, Gregory R., Foretz, Marc, Dayon, Loïc, Morrice, Nicholas A., Sakamoto, Kei

“…AMP-activated protein kinase (AMPK) is a key cellular energy sensor and regulator of metabolic homeostasis. Although it is best known for its effects on…”
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Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662 by Ducommun, Serge, Ford, Rebecca J, Bultot, Laurent, Deak, Maria, Bertrand, Luc, Kemp, Bruce E, Steinberg, Gregory R, Sakamoto, Kei

“…AMP-activated protein kinase (AMPK) is a key cellular energy sensor and regulator of metabolic homeostasis. Activation of AMPK provides beneficial outcomes in…”
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AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues by Wang, Hong Yu, Ducommun, Serge, Quan, Chao, Xie, Bingxian, Li, Min, Wasserman, David H, Sakamoto, Kei, Mackintosh, Carol, Chen, Shuai

“…AS160 (Akt substrate of 160 kDa) is a Rab GTPase-activating protein implicated in insulin control of GLUT4 (glucose transporter 4) trafficking. In humans, a…”
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Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition by Ducommun, Serge, Jannig, Paulo R., Cervenka, Igor, Murgia, Marta, Mittenbühler, Melanie J., Chernogubova, Ekaterina, Dias, José M., Jude, Baptiste, Correia, Jorge C., Van Vranken, Jonathan G., Ocana-Santero, Gabriel, Porsmyr-Palmertz, Margareta, McCann Haworth, Sarah, Martínez-Redondo, Vicente, Liu, Zhengye, Carlström, Mattias, Mann, Matthias, Lanner, Johanna T., Teixeira, Ana I., Maegdefessel, Lars, Spiegelman, Bruce M., Ruas, Jorge L.

“…Skeletal muscle plasticity and remodeling are critical for adapting tissue function to use, disuse, and regeneration. The aim of this study was to identify…”
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Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity by Correia, Jorge C., Kelahmetoglu, Yildiz, Jannig, Paulo R., Schweingruber, Christoph, Shvaikovskaya, Dasha, Zhengye, Liu, Cervenka, Igor, Khan, Naveen, Stec, Michael, Oliveira, Mariana, Nijssen, Jik, Martínez-Redondo, Vicente, Ducommun, Serge, Azzolini, Michele, Lanner, Johanna T., Kleiner, Sandra, Hedlund, Eva, Ruas, Jorge L.

“…Endurance exercise promotes skeletal muscle vascularization, oxidative metabolism, fiber-type switching, and neuromuscular junction integrity. Importantly, the…”
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The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids by Desjardins, Eric M, Smith, Brennan K, Day, Emily A, Ducommun, Serge, Sanders, Matthew J, Nederveen, Joshua P, Ford, Rebecca J, Pinkosky, Stephen L, Townsend, Logan K, Gutgesell, Robert M, Lu, Rachel, Sakamoto, Kei, Steinberg, Gregory R

“…Fatty acids are vital for the survival of eukaryotes, but when present in excess can have deleterious consequences. The AMP-activated protein kinase (AMPK) is…”
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Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and remodeling by Correia, Jorge C, Jannig, Paulo R, Gosztyla, Maya L, Cervenka, Igor, Ducommun, Serge, Præstholm, Stine M, Dias, José M, Dumont, Kyle D, Liu, Zhengye, Liang, Qishan, Edsgärd, Daniel, Emanuelsson, Olof, Gregorevic, Paul, Westerblad, Håkan, Venckunas, Tomas, Brazaitis, Marius, Kamandulis, Sigitas, Lanner, Johanna T, Teixeira, Ana I, Yeo, Gene W, Ruas, Jorge L

“…Skeletal muscle atrophy is a morbidity and mortality risk factor that happens with disuse, chronic disease, and aging. The tissue remodeling that happens…”
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Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates by Ducommun, Serge, Deak, Maria, Zeigerer, Anja, Göransson, Olga, Seitz, Susanne, Collodet, Caterina, Madsen, Agnete B., Jensen, Thomas E., Viollet, Benoit, Foretz, Marc, Gut, Philipp, Sumpton, David, Sakamoto, Kei

“…AMP-activated protein kinase (AMPK) is a key regulator of cellular energy homeostasis, acting as a sensor of energy and nutrient status. As such, AMPK is…”
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A Tbc1d1 ^sup Ser231Ala^-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice by Chen, Qiaoli, Xie, Bingxian, Zhu, Sangsang, Rong, Ping, Sheng, Yang, Ducommun, Serge, Chen, Liang, Quan, Chao, Li, Min, Sakamoto, Kei, Mackintosh, Carol, Chen, Shuai, Wang, Hong Yu

“…Aims/hypothesis TBC1D1 (tre-2/USP6, BUB2, cdc16 domain family member 1) is a Rab GTPase-activating protein (RabGAP) that has been implicated in regulating…”
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A Tbc1d1 super(Ser231Ala)-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice by Chen, Qiaoli, Xie, Bingxian, Zhu, Sangsang, Rong, Ping, Sheng, Yang, Ducommun, Serge, Chen, Liang, Quan, Chao, Li, Min, Sakamoto, Kei, MacKintosh, Carol, Chen, Shuai, Wang, Hong Yu

“…TBC1D1 (tre-2/USP6, BUB2, cdc16 domain family member 1) is a Rab GTPase-activating protein (RabGAP) that has been implicated in regulating GLUT4 trafficking…”
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A Tbc1d1 Ser231Ala -knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice by Chen, Qiaoli, Xie, Bingxian, Zhu, Sangsang, Rong, Ping, Sheng, Yang, Ducommun, Serge, Chen, Liang, Quan, Chao, Li, Min, Sakamoto, Kei, MacKintosh, Carol, Chen, Shuai, Wang, Hong Yu

“…TBC1D1 (tre-2/USP6, BUB2, cdc16 domain family member 1) is a Rab GTPase-activating protein (RabGAP) that has been implicated in regulating GLUT4 trafficking…”
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A Tbc1d1Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice by Chen, Qiaoli, Xie, Bingxian, Zhu, Sangsang, Rong, Ping, Sheng, Yang, Ducommun, Serge, Chen, Liang, Quan, Chao, Li, Min, Sakamoto, Kei, MacKintosh, Carol, Chen, Shuai, Wang, Hong Yu

“…Aims/hypothesis TBC1D1 (tre-2/USP6, BUB2, cdc16 domain family member 1) is a Rab GTPase-activating protein (RabGAP) that has been implicated in regulating…”
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Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle by Sakakibara, Iori, Wurmser, Maud, Dos Santos, Matthieu, Santolini, Marc, Ducommun, Serge, Davaze, Romain, Guernec, Anthony, Sakamoto, Kei, Maire, Pascal

“…Adult skeletal muscles are composed of slow and fast myofiber subtypes which each express selective genes required for their specific contractile and metabolic…”
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Thr649Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle by Ducommun, Serge, Wang, Hong Yu, Sakamoto, Kei, MacKintosh, Carol, Chen, Shuai

“…AS160 and its closely related protein TBC1D1 have emerged as key mediators for both insulin- and contraction-stimulated muscle glucose uptake through…”
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