Search Results - "Duckworth, P"

Adenylating enzymes in Mycobacterium tuberculosis as drug targets by Duckworth, Benjamin P, Nelson, Kathryn M, Aldrich, Courtney C

“…Adenylation or adenylate-forming enzymes (AEs) are widely found in nature and are responsible for the activation of carboxylic acids to intermediate…”
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Poor glycaemic control and ectopic fat deposition mediates the increased risk of non-alcoholic steatohepatitis in high-risk populations with type 2 diabetes: Insights from Bayesian-network modelling by Waddell, T, Namburete, A, Duckworth, P, Fichera, A, Telford, A, Thomaides-Brears, H, Cuthbertson, D J, Brady, M

“…An estimated 55.5% and 37.3% of people globally with type 2 diabetes (T2D) will have concomitant non-alcoholic fatty liver disease (NAFLD) and the more severe…”
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Bayesian networks and imaging-derived phenotypes highlight the role of fat deposition in COVID-19 hospitalisation risk by Waddell, T, Namburete, A I L, Duckworth, P, Eichert, N, Thomaides-Brears, H, Cuthbertson, D J, Despres, J P, Brady, M

“…Obesity is a significant risk factor for adverse outcomes following coronavirus infection (COVID-19). However, BMI fails to capture differences in the body fat…”
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Development of a high-throughput fluorescence polarization assay for the discovery of phosphopantetheinyl transferase inhibitors by Duckworth, Benjamin P., Aldrich, Courtney C.

“…An alarming number of clinically relevant bacterial pathogens are becoming resistant to many antibiotics, thereby fueling intense research into the discovery…”
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Development of a Selective Activity-Based Probe for Adenylating Enzymes: Profiling MbtA Involved in Siderophore Biosynthesis from Mycobacterium tuberculosis by Duckworth, Benjamin P, Wilson, Daniel J, Nelson, Kathryn M, Boshoff, Helena I, Barry, Clifton E, Aldrich, Courtney C

“…MbtA is an adenylating enzyme from Mycobacterium tuberculosis that catalyzes the first step in the biosynthesis of the mycobactins. A bisubstrate inhibitor of…”
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Universal Method for the Preparation of Covalent Protein-DNA Conjugates for Use in Creating Protein Nanostructures by Duckworth, Benjamin P, Chen, Yan, Wollack, James W, Sham, Yuk, Mueller, Joachim D, Taton, T. Andrew, Distefano, Mark D

“…Protein patterning: A protein, selectively labeled with an azide tag, was reacted with alkyne‐functionalized DNA. These protein–DNA conjugates were used to…”
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Biochemical and Structural Characterization of Bisubstrate Inhibitors of BasE, the Self-Standing Nonribosomal Peptide Synthetase Adenylate-Forming Enzyme of Acinetobactin Synthesis by Drake, Eric J, Duckworth, Benjamin P, Neres, João, Aldrich, Courtney C, Gulick, Andrew M

“…The human pathogen Acinetobacter baumannii produces a siderophore called acinetobactin that is derived from one molecule each of threonine, histidine, and…”
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Sexual Victimization and Benefit Expectations of Risky Behavior Among Female College Students by Carlson, Gwendolyn C., Duckworth, Melanie P.

“…Sexual victimization has been shown to positively relate to both engagement in risky behavior and subsequent sexual victimization. Research has focused on the…”
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Chronic Pain and Posttraumatic Stress Symptoms in Litigating Motor Vehicle Accident Victims by Duckworth, Melanie P, Iezzi, Tony

“…OBJECTIVE:There has been little research examining chronic pain and posttraumatic stress symptoms in persons injured in motor vehicle accidents. The purpose of…”
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The Development of Video Messages to Reduce Binge Drinking: Focus Group Results by Carlson, Gwendolyn C, Duckworth, Melanie P

“…The current study examined college students' perceptions of loss framed and gain framed messages aimed at reducing binge drinking. Using focus groups (n = 3)…”
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Structure–activity relationships of 2-aminothiazoles effective against Mycobacterium tuberculosis by Meissner, Anja, Boshoff, Helena I., Vasan, Mahalakshmi, Duckworth, Benjamin P., Barry, Clifton E., Aldrich, Courtney C.

“…A series of 2-aminothiazoles was synthesized based on a HTS scaffold from a whole-cell screen against Mycobacterium tuberculosis (Mtb). The SAR shows the…”
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Motor Vehicle Collisions and Their Consequences—Part II: Predictors of Impairment and Disability by Duckworth, Melanie P., Iezzi, Tony

“…A significant number of persons involved in motor vehicle collisions (MVCs) evidence persistent changes in physical, psychosocial, and cognitive functioning…”
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Motor Vehicle Collisions and Their Consequences—Part 1: Common Physical, Psychosocial, and Cognitive Outcomes by Iezzi, Tony, Duckworth, Melanie P.

“…Motor vehicle collisions (MVCs) have a significant impact on injured persons and society. MVCs generally result in property damage, but more serious MVCs often…”
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Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium tuberculosis by Nelson, Kathryn M., Viswanathan, Kishore, Dawadi, Surendra, Duckworth, Benjamin P., Boshoff, Helena I., Barry, Clifton E., Aldrich, Courtney C.

“…MbtA catalyzes the first committed biosynthetic step of the mycobactins, which are important virulence factors associated with iron acquisition in…”
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Fluorescent peptide sensors for tyrosylprotein sulfotransferase activity by Zhou, Wenbo, Duckworth, Benjamin P., Geraghty, Robert J.

“…Tyrosine sulfurylation is a post-translational modification important for protein–protein interactions in the extracellular space that are instrumental in cell…”
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The effects of body size and vitamin D status on bone mass of British women from South Asian and European origin: results from the Vitamin D, Food Intake, Nutrition and Exposure to Sunlight in Southern England (D-FINES) Study by Lee, W. T. K., Darling, A. L., Lee, P. A., Osborn, A., Hanjra, F., Duckworth, P., Cardew, P., Patel, S., Gray, R., Lanham-New, S. A.

“…Promotion of higher peak bone mass in younger SA women by promoting a healthy body weight, regular sunshine exposure, regular PA and the use of vitamin…”
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Selective Labeling of Proteins by Using Protein Farnesyltransferase by Duckworth, Benjamin P., Zhang, Zhiyuan, Hosokawa, Ayako, Distefano, Mark D.

“…The challenging task of identifying and studying protein function has been greatly aided by labeling proteins with reporter groups. Here, we present a strategy…”
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Introduction to the Special Issue on Motor Vehicle Collisions and Their Wide-Ranging Consequences by Duckworth, Melanie P., Iezzi, Tony

“…MVC-related injuries also often result in physical, psychological, and cognitive symptoms that have profound effects on quality of life and emotional…”
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Measurement of Nonribosomal Peptide Synthetase Adenylation Domain Activity Using a Continuous Hydroxylamine Release Assay by Duckworth, Benjamin P, Wilson, Daniel J, Aldrich, Courtney C

“…Adenylation is a crucial enzymatic process in the biosynthesis of nonribosomal peptide synthetase (NRPS) derived natural products. Adenylation domains are…”
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Psycholegal Assessment of Co-occurring Chronic Pain and Schizophrenia Post-MVC: Analysis of Causation Using Two Case Examples by Iezzi, Tony, Duckworth, Melanie P.

“…The key aspect of any psycholegal assessment is the analysis of causation, which requires consideration of important legal constructs such as the but for test…”
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