Search Results - "Ducibella, Tom"

The roles of Ca2+, downstream protein kinases, and oscillatory signaling in regulating fertilization and the activation of development by Ducibella, Tom, Fissore, Rafael

“…Reviews in Developmental Biology have covered the pathways that generate the all-important intracellular calcium (Ca2+) signal at fertilization [Miyazaki, S.,…”
Get full text

Fertilization stimulates long-lasting oscillations of CaMKII activity in mouse eggs by Markoulaki, Styliani, Matson, Sara, Ducibella, Tom

“…Elucidation of the biochemical mechanisms by which specific proteins transduce the all important intracellular calcium (Ca 2+) signal at fertilization into…”
Get full text

Egg activation events are regulated by the duration of a sustained [Ca 2+] cyt signal in the mouse by Ozil, Jean-Pierre, Markoulaki, Styliani, Toth, Szabolcs, Matson, Sara, Banrezes, Bernadette, Knott, Jason G., Schultz, Richard M., Huneau, Daniel, Ducibella, Tom

“…Although the dynamics of oscillations of cytosolic Ca 2+ concentration ([Ca 2+] cyt) play important roles in early mammalian development, the impact of the…”
Get full text

Antagonists of Myosin Light Chain Kinase and of Myosin II Inhibit Specific Events of Egg Activation in Fertilized Mouse Eggs by MATSON, Sara, MARKOULAKI, Styliani, DUCIBELLA, Tom

“…Although recent studies have demonstrated the importance of calcium/calmodulin (Ca 2+ /CAM) signaling in mammalian fertilization, many targets of Ca 2+ /CAM…”
Get full text

Oscillatory CaMKII activity in mouse egg activation by Markoulaki, Styliani, Matson, Sara, Abbott, Allison L, Ducibella, Tom

“…Fertilization-induced intracellular calcium (Ca 2+) oscillations stimulate the onset of mammalian development, and little is known about the biochemical…”
Get full text

Antagonists of Myosin Light Chain Kinase and of Myosin II Inhibit Specific Events of Egg Activation in Fertilized Mouse Eggs1 by Matson, Sara, Markoulaki, Styliani, Ducibella, Tom

“…Although recent studies have demonstrated the importance of calcium/calmodulin (Ca2+/CAM) signaling in mammalian fertilization, many targets of Ca2+/CAM have…”
Get full text

Differential Distribution of Inositol Trisphosphate Receptor Isoforms in Mouse Oocytes by FISSORE, R. A, LONGO, F. J, ANDERSON, E, PARYS, J. B, DUCIBELLA, T

“…In mammalian fertilization, inositol 1,4,5-trisphosphate receptor (IP 3 R)-dependent Ca 2+ release is a crucial signaling event that originates from the…”
Get full text

Identification of a Translocation Deficiency in Cortical Granule Secretion in Preovulatory Mouse Oocytes by ABBOTT, Allison L, FISSORE, Rafael A, DUCIBELLA, Tom

“…Preovulatory, germinal vesicle (GV)-stage mouse oocytes are unable to undergo normal cortical granule (CG) secretion. Full secretory competence is observed by…”
Get full text

Competence to Undergo Normal, Fertilization-Induced Cortical Activation Develops after Metaphase I of Meiosis in Mouse Oocytes by Ducibella, Tom, Buetow, Jan

“…The purpose of this study was to determine at what stage of meiotic maturation mouse oocytes develop the ability to undergo sperm-induced activation, assayed…”
Get full text

Inhibition of the Inositol Trisphosphate Receptor of Mouse Eggs and A7r5 Cells by KN-93 via a Mechanism Unrelated to Ca2+/Calmodulin-dependent Protein Kinase II Antagonism by Smyth, Jeremy T, Abbott, Allison L, Lee, Bora, Sienaert, Ilse, Kasri, Nael Nadif, De Smedt, Humbert, Ducibella, Tom, Missiaen, Ludwig, Parys, Jan B, Fissore, Rafael A

“…KN-93, a Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) inhibitor, concentration-dependently and reversibly inhibited inositol 1,4,5-trisphosphate…”
Get full text

The MEK inhibitor, U0126, alters fertilization-induced [Ca 2+] i oscillation parameters and secretion: Differential effects associated with in vivo and in vitro meiotic maturation by Matson, Sara, Ducibella, Tom

“…Although mitogen-activated protein kinase (MAPK) is a well-known cell cycle regulator, emerging studies have also implicated its activity in the regulation of…”
Get full text

Effects of Calcium-BAPTA Buffers and the Calmodulin Antagonist W-7 on Mouse Egg Activation by Xu, Zhe, Lefevre, Leah, Ducibella, Tom, Schultz, Richard M., Kopf, Gregory S.

“…Results of numerous experiments indicate that the transient rise in intracellular Ca2+following sperm–egg fusion is essential for the subsequent events that…”
Get full text

Quantitative studies of changes in cortical granule number and distribution in the mouse oocyte during meiotic maturation by Ducibella, Tom, Anderson, Everett, Albertini, David F., Aalberg, Jeff, Rangarajan, Sathyabhama

“…Cortical granules (CGs) undergo a substantial change in distribution in the mouse oocyte cortex during meiotic maturation. In order to determine the mechanism…”
Get full text

Identification of a Translocation Deficiency in Cortical Granule Secretion in Preovulatory Mouse Oocytes1 by Abbott, Allison L, Fissore, Rafael A, Ducibella, Tom

“…Preovulatory, germinal vesicle (GV)-stage mouse oocytes are unable to undergo normal cortical granule (CG) secretion. Full secretory competence is observed by…”
Get full text

Role of calcium signals in early development by Ducibella, Tom, Schultz, Richard M., Ozil, Jean-Pierre

“…The mammalian egg appears to transduce the duration, amplitude, and temporal presentation of the increase in the intracellular calcium concentration ([Ca 2+]…”
Get full text

Egg-to-embryo transition is driven by differential responses to Ca(2+) oscillation number by Ducibella, Tom, Huneau, Daniel, Angelichio, Elizabeth, Xu, Zhe, Schultz, Richard M, Kopf, Gregory S, Fissore, Rafael, Madoux, Stephane, Ozil, Jean-Pierre

“…Ca(2+) oscillations and signaling represent a basic mechanism for controlling many cellular events. Activation of mouse eggs entrains a temporal series of…”
Get full text

The roles of Ca super(2+), downstream protein kinases, and oscillatory signaling in regulating fertilization and the activation of development by Ducibella, Tom, Fissore, Rafael

“…Reviews in Developmental Biology have covered the pathways that generate the all-important intracellular calcium (Ca super(2+)) signal at fertilization…”
Get full text

Differential Distribution of Inositol Trisphosphate Receptor Isoforms in Mouse Oocytes1 by Fissore, Rafael A., Longo, Frank J., Anderson, Everett, Parys, Jan B., Ducibella, Tom

Get full text

Isoforms of the Inositol 1,4,5-Trisphosphate Receptor Are Expressed in Bovine Oocytes and Ovaries: The Type-1 Isoform Is Down-Regulated by Fertilizationand by Injection of Adenophostin A1 by He, Chang Li, Damiani, Philip, Ducibella, Tom, Takahashi, Masaaki, Tanzawa, Kasuhiko, Parys, Jan B., Fissore, Rafael A.

Get full text

Egg-to-Embryo Transition Is Driven by Differential Responses to Ca2+ Oscillation Number by Ducibella, Tom, Huneau, Daniel, Angelichio, Elizabeth, Xu, Zhe, Schultz, Richard M., Kopf, Gregory S., Fissore, Rafael, Madoux, Stephane, Ozil, Jean-Pierre

Get full text