Search Results - "Duchen, M.R."

β-Amyloid Fragment 25–35 Causes Mitochondrial Dysfunction in Primary Cortical Neurons by Casley, C.S., Land, J.M., Sharpe, M.A., Clark, J.B., Duchen, M.R., Canevari, L.

“…β-Amyloid deposition and compromised energy metabolism both occur in vulnerable brain regions in Alzheimer's disease. It is not known whether β-amyloid is the…”
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P83 Investigating mitochondria in cell culture models of core myopathies by Munteanu, I, Zhou, H, Hargreaves, I, Yasukawa, T, Duchen, M.R, Muntoni, F

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O03 Dysregulation of calcium and mitochondrial function as potential therapeutic targets in muscle disease by Duchen, M.R, Heath, K, Baruch, N.B, Hanna, M.G, Muntoni, F

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P72 Uncovering the role of mitochondria in the pathogenesis of core myopathies by Munteanu, I, Yasukawa, T, Duchen, M.R, Muntoni, F

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Renal function and mitochondrial cytopathy (MC): more questions than answers? by Hall, A.M., Unwin, R.J., Hanna, M.G., Duchen, M.R.

“…Our knowledge of mitochondrial biology has advanced significantly in the last 10 years. The effects of mitochondrial dysfunction or cytopathy (MC) on the heart…”
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P24 Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signalling by Sharpe, J.A, Logan, C.V, Szabadkai, G, Parry, D.A, Torelli, S, Childs, A.-M, Kriek, M, Phadke, R, Johnson, C.A, Roberts, N.Y, Bonthron, D.T, Pysden, K.A, Whyte, T, Munteanu, I, Foley, A.R, Wheway, G, Szymanska, K, Natarajan, S, Abdelhamed, Z.A, Morgan, J.E, Roper, H, Santen, G.W.E, Niks, E.H, van der Pol, W.L, Lindhout, D, Raffaello, A, De Stefani, D, den Dunnen, J.T, Sun, Y, Ginjaar, I, Sewry, C.A, Hurles, M, Rizzuto, R, Duchen, M.R, Muntoni, F, Sheridan, E

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Mitochondria and Ca2+in cell physiology and pathophysiology by Duchen, M.R.

“…There is now a consensus that mitochondria take up and accumulate Ca2+during physiological [Ca2+]csignalling. This contribution will consider some of the…”
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Rosiglitazone protects differentiated SH-SY5Y cells against damage induced by rotenone through mitochondrial biogenesis and by anti-oxidative mechanisms by Corona, J.C., Duchen, M.R.

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Mitochondrial function and redox state in mammalian embryos by Dumollard, R., Carroll, J., Duchen, M.R., Campbell, K., Swann, K.

“…Mitochondria play a central and multifaceted role in the mammalian egg and early embryo, contributing to many different aspects of early development. While the…”
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Differential expression of membrane currents in dissociated mouse primary sensory neurons by Pearce, R J, Duchen, M R

“…The whole cell configuration of the patch clamp technique has been applied to identify the membrane currents expressed by populations of dissociated mouse…”
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Biophysical studies of the cellular elements of the rabbit carotid body by Duchen, M R, Caddy, K W, Kirby, G C, Patterson, D L, Ponte, J, Biscoe, T J

“…The carotid body is a major sensor of oxygen partial pressure in the arterial blood, and plays a role in the control of respiration. Despite extensive…”
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Heme Oxygenase 1 Induction In The Peri-Infarct Region After Cerebral Ischemia-Reperfusion Injury In Rats Is Associated With Reduced Blood-Brain Barrier Breakdown by Alfieri⁎, A., Srivastava, S., Siow, R.C.M., Duchen, M.R., Fraser, P.A., Mann et al, G.E.

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Albumin uptake in OK cells exposed to rotenone: a model for studying the effects of mitochondrial dysfunction on endocytosis in the proximal tubule? by Hall, A M, Campanella, M, Loesch, A, Duchen, M R, Unwin, R J

“…The renal proximal tubule (PT) is clinically vulnerable to mitochondrial dysfunction; sub-lethal injury can lead to the Fanconi syndrome, with elevated urinary…”
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Mechanisms of intracellular calcium regulation in adult astrocytes by Peuchen, S., Clark, J.B., Duchen, M.R.

“…Microfluorimetric techniques were used to measure changes in intracellular calcium in astrocytes cultured from the forebrain of the adult rat. Application of…”
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Energy metabolism of adult astrocytes in vitro by Peuchen, S., Duchen, M.R., Clark, J.B.

“…In this study we established cultures of astrocytes from the forebrain of the adult rat. The homeostatic regulatory mechanisms of the aerobic and anaerobic…”
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An intracellular study of the interactions of N-methyl-DL-aspartate with ketamine in the mouse hippocampal slice by Duchen, M R, Burton, N R, Biscoe, T J

“…Intracellular recordings were made from dentate and CA1 pyramidal cells of the mouse hippocampal slice preparation. N-methyl-DL-aspartate (NMDLA), quisqualate…”
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Primary afferent terminal excitability in the normal and spastic mutant mouse spinal cord by Yu, Y B, Duchen, M R, Biscoe, T J

“…A microcomputer-based system has been used to apply the technique of excitability testing to the study of the actions of a range of pharmacological agents on…”
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