Search Results - "Ducharme, MP"

A pharmacokinetic study of amoxycillin in febrile beagle dogs following repeated administrations of endotoxin by Marier, J.-F., Beaudry, F., Ducharme, M. P., Fortin, D., Moreau, J.-P., Massé, R., Vachon, P.

“…The pharmacokinetics of amoxycillin was studied in nine male beagle dogs under healthy and febrile conditions. In Period 1, dogs received 20 mg/kg of an oral…”
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Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model by Marier, Jean-Francois, Vachon, Pascal, Gritsas, Ari, Zhang, Jie, Moreau, Jean-Pierre, Ducharme, Murray P

“…Pharmacokinetics of trans-resveratrol in its aglycone (RES(AGL)) and glucuronide (RES(GLU)) forms were studied following intravenous (15 mg/kg i.v.) and oral…”
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Novel pharmacokinetic modelling of transdermal nitroglycerin by AUCLAIR, B, SIROIS, G, ANH HO NGOC, DUCHARME, M. P

“…To construct a pharmacokinetic (PK) model and to determine population PK parameters of nitroglycerin (GTN), 1,2-dinitroglycerin (1,2-GDN), and…”
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Pomelo juice, but not cranberry juice, affects the pharmacokinetics of cyclosporine in humans by Grenier, Julie, Fradette, Caroline, Morelli, Gaetano, Merritt, Gerald J., Vranderick, Manon, Ducharme, Murray P.

“…Background Cyclosporine (INN, ciclosporin) is a cytochrome P450 (CYP) 3A and P‐glycoprotein (P‐gp) substrate whose bioavailability increases when administered…”
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Effect of Food on the Pharmacokinetics of Single- and Multiple-Dose Hydrocodone Extended Release in Healthy Subjects by Bond, Mary, Rabinovich-Guilatt, Laura, Selim, Sally, Darwish, Mona, Tracewell, William, Robertson, Philmore, Yang, Ronghua, Malamut, Richard, Colucci, Philippe, Ducharme, Murray P., Spiegelstein, Ofer

“…Background and objectives Food intake can alter the pharmacokinetics of certain medications, including changes in their oral bioavailability, which is of…”
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The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: The role of gut CYP3A and P-glycoprotein by Di Marco, Marika Pasternyk, Edwards, David J, Wainer, Irving W, Ducharme, Murray P

“…The objective of this study was to determine the effects of grapefruit juice and seville orange juice on dextromethorphan (DM) pharmacokinetics. Eleven healthy…”
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Disposition of intravenous and oral cyclosporine after administration with grapefruit juice by Ducharme, M P, Warbasse, L H, Edwards, D J

“…To examine the effect of grapefruit juice on the disposition of cyclosporine after administration of oral and intravenous doses to healthy male subjects…”
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6′,7′-Dihydroxybergamottin in grapefruit juice and Seville orange juice: Effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein by Edwards, David J., Fitzsimmons, Michael E., Schuetz, Erin G., Yasuda, Kazuto, Ducharme, Murray P., Warbasse, Lawrence H., Woster, Patrick M., Schuetz, John D., Watkins, Paul

“…Background 6′,7′‐Dihydroxybergamottin is a furanocoumarin that inhibits CYP3A4 and is found in grapefruit juice and Seville orange juice. Grapefruit juice…”
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Bioequivalence of oxycodone hydrochoride extended release tablets to marketed reference products OxyContin® in Canada and US by GOSAI, Pritti, DUCHARME, Murray P, GODFREY, Anthony R, FREEMAN, James C, MONIF, Tausif, KSHIRASAGAR SANTOSH KUMAR, KUMAR, Sudershan, MUDNAIK, Rajesh, KATIKANENI, Pruthvipathy

“…Oxycodone is a semisynthetic opioid agonist used for the relief of moderate to severe pain. A new generic oxycodone hydrochloride (HCl) extended release (ER)…”
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Phase I and Pharmacokinetic Study of DE-310 in Patients with Advanced Solid Tumors by SOEPENBERG, Otto, DE JONGE, Maja J. A, SPARREBOOM, Alex, DE BRUIN, Peter, ESKENS, Ferry A. L. M, DE HEUS, Gerda, WANDERS, Jantien, CHEVERTON, Peter, DUCHARME, Murray P, VERWEIJ, Jaap

“…Purpose: To assess the maximum-tolerated dose, toxicity, and pharmacokinetics of DE-310, a macromolecular prodrug of the topoisomerase I inhibitor exatecan…”
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Liposomal tobramycin against pulmonary infections of Pseudomonas aeruginosa: a pharmacokinetic and efficacy study following single and multiple intratracheal administrations in rats by Marier, J. F., Brazier, J. L., Lavigne, J., Ducharme, M. P.

“…Objective: To determine the pharmacokinetics and efficacy of tobramycin against pulmonary infections of Pseudomonas aeruginosa in rats after intratracheal…”
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A Population Pharmacokinetic Model for Vancomycin in Pediatric Patients and Its Predictive Value in a Naive Population by LAMARRE, P, LEBEL, D, DUCHARME, M. P

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Pharmacokinetics of omeprazole in healthy adults and in children with gastroesophageal reflux disease by Marier, Jean-Francois, Dubuc, Marie-Claude, Drouin, Eric, Alvarez, Fernando, Ducharme, Murray P, Brazier, Jean-Louis

“…Studies of the pharmacokinetics of omeprazole in children with gastroesophageal reflux disease (GERD) remain scarce despite the vast number of reports on its…”
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Phase I and Pharmacokinetic Study of Exatecan Mesylate (DX-8951f): A Novel Camptothecin Analog by ROYCE, Melanie E, HOFF, Paulo M, DUMAS, Pamela, LASSERE, Yvonne, LEE, J. Jack, COYLE, John, DUCHARME, Murray P, DE JAGER, Robert, PAZDUR, Richard

“…To determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacokinetic (PK) profile, and recommended phase II dose of Exatecan mesylate…”
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Vancomycin pharmacokinetics in a patient population: effect of age, gender, and body weight by Ducharme, M P, Slaughter, R L, Edwards, D J

“…The effects of age, gender, and body weight on the pharmacokinetics of vancomycin were examined using data collected as part of routine therapeutic drug…”
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Trough concentrations of cyclosporine in blood following administration with grapefruit juice by DUCHARME, MURRAY P., PROVENZANO, ROBERT, DEHOORNE‐SMITH, MICHELLE, EDWARDS, DAVID J.

“…Components of grapefruit juice have been shown to inhibit CYP3A4 activity, the enzyme involved in cyclosporine metabolism. Eleven medically stable patients…”
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A population pharmacokinetic-metabolism model for individualizing ciprofloxacin therapy in ophthalmology by Di Marco, Marika Pasternyk, Chen, John, Wainer, Irving W, Ducharme, Murray P

“…The purpose of this study was to construct a population pharmacokinetic (PK) metabolism (MB) model to describe ciprofloxacin (C) concentrations in plasma and…”
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Piperacillin and Tazobactam Exhibit Linear Pharmacokinetics after Multiple Standard Clinical Doses by AUCLAIR, B, DUCHARME, M. P

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Phase I Study of Topoisomerase I Inhibitor Exatecan Mesylate (DX-8951f) Given as Weekly 24-Hour Infusions Three of Every Four Weeks by SHARMA, Sunil, KEMENY, Nancy, HOLLYWOOD, Ellen, SALTZ, Leonard B, SCHWARTZ, Gary K, KELSEN, David, O'REILLY, Eileen, ILSON, David, COYLE, John, DE JAGER, Robert L, DUCHARME, Martin P, KLEBAN, Sarah

“…Exatecan mesylate (DX-8951f) is a topoisomerase I inhibitor that has increased solubility and antitumor activity compared with other topoisomerase I…”
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Itraconazole and hydroxyitraconazole serum concentrations are reduced more than tenfold by phenytoin by Ducharme, M P, Slaughter, R L, Warbasse, L H, Chandrasekar, P H, Van de Velde, V, Mannens, G, Edwards, D J

“…To study the disposition of single doses of phenytoin and itraconazole when administered alone and after chronic treatment with the other drug. Healthy male…”
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