Multidimensional Analysis of the Mother-to-child Transmission Risk Factors in Chronic Hepatitis B Virus Infection in Pregnant Women in Vietnam

Multidimensional Analysis of the Mother-to-child Transmission Risk Factors in Chronic Hepatitis B Virus Infection in Pregnant Women in Vietnam

Hepatitis B virus (HBV) infection remains a major public health problem. The interaction between HBV and the host inflammatory response is an important factor contributing to liver damage and disease development. We investigate of the correlation between peripheral blood cell levels, HBV DNA, and th...

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Bibliographic Details
Published in:Clinica terapeutica Vol. 174; no. 3; p. 266
Main Authors: Ngoc Tram, H T, Thu Huong, B T, Duc Hinh, N, Thuy, P T, Lan Anh, L T, Kim Phuon, D T, Thu Lan, H, Cam Tu, H, Koerber, N, Bauer, T, Khanh Lam, H, Manh Ha, N, Minh Duc, N, Thanh Hiep, N, Protzer, U, Tien Dung, N
Format: Journal Article
Language:English
Published: Italy 01-05-2023
Subjects:
DNA, Viral - genetics
Female
Hepatitis B
Hepatitis B e Antigens
Hepatitis B Surface Antigens
Hepatitis B virus - genetics
Hepatitis B, Chronic - epidemiology
Humans
Infant
Infectious Disease Transmission, Vertical
Leukocytes, Mononuclear
Pregnancy
Pregnancy Complications, Infectious - epidemiology
Pregnant Women
Risk Factors
Vietnam - epidemiology
Vietnam
Chronic hepatitis B virus infection
peripheral blood mononuclear cells
cord blood
pregnant women
cord blood mononuclear cells
liver
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Summary:Hepatitis B virus (HBV) infection remains a major public health problem. The interaction between HBV and the host inflammatory response is an important factor contributing to liver damage and disease development. We investigate of the correlation between peripheral blood cell levels, HBV DNA, and the risk of transmission to the baby in pregnant women infected with hepatitis B. A multidimensional analysis was performed on data collected from 60 Vietnamese pregnant women and their babies (cord blood). Taking the risk ratio test results of cord blood HBsAg as a positive probability, the boundary of maternal PBMC concentration is 8.03x106 cells/ml (with negative correlation) and for CBMCs is 6.64x106 cells/ml (with positive correlation). That means that HBsAg positivity in the blood may be related to the increasing of CBMCs and the diminution of maternal PBMCs. When the maternal viral load is higher than 5x107 copies/ml, the risk of being HBsAg-positive in cord blood is 123% (RR=2.23 [1.48,3.36]); when the viral load is lower than this baseline, the risk is decreased by 55% (RR=0.45 [0.30,0.67]) (p<0.001). With several steps of the analysis, this study found maternal peripheral blood cell levels and cord blood positively cor-related in pregnant women with a load lower than 5x107 copies of HBV DNA/ml. The study's results suggest that the role of PBMCs and HBV DNA in vertical infection is essential.
ISSN:1972-6007
DOI:10.7417/CT.2023.2533