Search Results - "Dubuc, I."

A potential role for the secretogranin II‐derived peptide EM66 in the hypothalamic regulation of feeding behaviour by Trebak, F., Dubuc, I., Arabo, A., Alaoui, A., Boukhzar, L., Maucotel, J., Picot, M., Cherifi, S., Duparc, C., Leprince, J., Prévost, G., Anouar, Y., Magoul, R., Chartrel, N.

“…EM66 is a conserved 66‐amino acid peptide derived from secretogranin II (SgII), a member of the granin protein family. EM66 is widely distributed in secretory…”
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Comparisons between bupropion and dexamphetamine in a range of in vivo tests exploring dopaminergic transmission by Bredeloux, P, Dubuc, I, Costentin, J

“…Background and purpose: In the present study we investigated, in a range of in vivo tests whether the antidepressant bupropion, and its metabolites shared the…”
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Interactions between NTS2 neurotensin and opioid receptors on two nociceptive responses assessed on the hot plate test in mice by Bredeloux, Pierre, Costentin, Jean, Dubuc, Isabelle

“…The intracerebroventricular administration of the tridecapeptide neurotensin (NT) produces strong analgesic effects in tests evaluating acute pain. We…”
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The nonpeptide neurotensin antagonist, SR 48692, used as a tool to reveal putative neurotensin receptor subtypes by Dubuc, I., Costentin, J., Terranova, J.P., Barnouin, M.C., Soubrié, P., Fur, G. Le, Rostène, W., Kitabgi, P.

“…The nonpeptide neurotensin (NT) antagonist, SR 48692, was recently shown to inhibit NT binding to the cloned rat and human NT receptor and to antagonize NT…”
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In vivo and in vitro structure-activity studies with peptide and pseudopeptide neurotensin analogs suggest the existence of distinct central neurotensin receptor subtypes by Labbé-Jullié, C, Dubuc, I, Brouard, A, Doulut, S, Bourdel, E, Pelaprat, D, Mazella, J, Martinez, J, Rostène, W, Costentin, J

“…The present study was designed to compare, with respect to structure-activity relationships, the receptors that subserve the hypothermic and analgesic effects…”
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Localization of neurotensin NTS2 receptors in rat brain, using [3H]levocabastine by Asselin, Marie-Liesse, Dubuc, Isabelle, Coquerel, Antoine, Costentin, Jean

“…The brain localization of the neurotensin receptor NTS2 was studied with [H]levocabastine, using an autoradiographic procedure. This study suggests that NTS2…”
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A potential role for the secretogranin II ‐derived peptide EM 66 in the hypothalamic regulation of feeding behaviour by Trebak, F., Dubuc, I., Arabo, A., Alaoui, A., Boukhzar, L., Maucotel, J., Picot, M., Cherifi, S., Duparc, C., Leprince, J., Prévost, G., Anouar, Y., Magoul, R., Chartrel, N.

“…EM 66 is a conserved 66‐amino acid peptide derived from secretogranin II (Sg II ), a member of the granin protein family. EM 66 is widely distributed in…”
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A C-terminal cyclic 8–13 neurotensin fragment analog appears less exposed to neprilysin when it crosses the blood-brain barrier than the cerebrospinal fluid-brain barrier in mice by Van Kemmel, F.-M., Dubuc, I., Bourdel, E., Fehrentz, J.-A., Martinez, J., Costentin, J.

“…A C-terminal cyclic 8–13 neurotensin fragment analog, JMV 1193, a direct agonist of central neurotensin receptors, is able to cross both the cerebrospinal…”
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Tolerance to the hypothermic but not to the analgesic effect of [D-Trp11]neurotensin during the semichronic intracerebroventricular infusion of the peptide in rats by Dubuc, I, Pain, C, Suaudeau, C, Costentin, J

“…The peptidase-resistant derivative of neurotensin, [D-Trp11]neurotensin, has been continuously infused intracerebroventricularly (75 ng/h) with an osmotic…”
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Developmental changes of (3)H-labelled mu-opioid receptors in brainstems of intra-uterine growth-restricted rats by Liu, J, Dong, C, Cazin, L, Clabaut, M, Dubuc, I, Costentin, J, Coquerel, A

“…The opioid mu-system is involved in brainstem-mediated respiratory control. Infants with intra-uterine growth restriction (IUGR) have more respiratory…”
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Centrally administered [D-Trp11]neurotensin, as well as neurotensin protected from inactivation by thiorphan, modifies locomotion in rats in a biphasic manner by Nouel, D, Dubuc, I, Kitabgi, P, Costentin, J

“…Neurotensin injected intracerebroventricularly at the dose of 30 ng per rat was without intrinsic effect on locomotion. When associated with the enkephalinase…”
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Effects of thiorphan, bestatin and a novel metallopeptidase inhibitor JMV 390-1 on the recovery of neurotensin and neuromedin N released from mouse hypothalamus by Kitabgi, P, Dubuc, I, Nouel, D, Costentin, J, Cuber, J C, Fulcrand, H, Doulut, S, Rodriguez, M, Martinez, J

“…The effects of the endopeptidase 24.11 ('enkephalinase') inhibitor thiorphan, the aminopeptidase inhibitor bestatin and a novel metallopeptidase inhibitor JMV…”
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Hypothermic effect of neuromedin N in mice and its potentiation by peptidase inhibitors by Dubuc, I, Nouel, D, Coquerel, A, Menard, J F, Kitabgi, P, Costentin, J

“…The intracerebroventricular administration of neuromedin N (from 50 ng to 5 micrograms) elicited a dose- and time-dependent hypothermia in mice. Two…”
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Calcium-dependent release of neuromedin N and neurotensin from mouse hypothalamus by Kitabgi, P, De Nadai, F, Cuber, J C, Dubuc, I, Nouel, D, Costentin, J

“…Neuromedin N (NN), a hexapeptide, was isolated from porcine spinal cord. Its C-terminal tetrapeptide sequence is identical to that of neurotensin (NT) and it…”
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Functional and pharmacological aspects of central neuropeptidergic transmission mediated by neurotensin and neuromedin n by Kitabgi, P, De Nadai, F, Labbe-Jullie, C, Dubuc, I, Nouel, D, Costentin, J, Masuo, Y, Rostene, W, Woulfe, J, Lafortune, L

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Antagonism of the apomorphine-induced yawning by "atypical" neuroleptics by Dubuc, I, Protais, P, Colboc, O, Costentin, J

“…In relatively small doses, the four "atypical" neuroleptics, sulpiride, clozapine, thoiridazine and mezilamine were effective antagonists of…”
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Naloxone-insensitive potentiation of neurotensin hypothermic effect by the enkephalinase inhibitor thiorphan by Coquerel, A, Dubuc, I, Menard, J F, Kitabgi, P, Costentin, J

“…The hypothermic effect of neurotensin (0.1 microgram) injected i.c.v. in mice is potentiated by the enkephalinase inhibitor thiorphan (10 micrograms, i.c.v.)…”
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Identification of the Receptor Subtype Involved in the Analgesic Effect of Neurotensin by Dubuc, Isabelle, Sarret, Philippe, Labbe-Jullie, Catherine, Botto, Jean-Marie, Honore, Eric, Bourdel, Elisabeth, Martinez, Jean, Costentin, Jean, Vincent, Jean-Pierre, Kitabgi, Patrick, Mazella, Jean

“…The neuropeptide neurotensin (NT) elicits hypothermic and naloxone-insensitive analgesic responses after brain injection. Recent pharmacological evidence…”
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The partial agonist properties of levocabastine in neurotensin-induced analgesia by Dubuc, Isabelle, Remande, Sandra, Costentin, Jean

“…The antihistaminic drug levocabastine is a ligand for the low affinity neurotensin receptor (NTS2). Its intracerebroventricular administration to mice induced…”
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Behavioural data suggesting the plurality of central dopamine receptors by Costentin, J, Dubuc, I, Protais, P

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