Melatonin Modifies the Rhythm of Protein Synthesis

Melatonin Modifies the Rhythm of Protein Synthesis

Melatonin (5 nM) added to medium with primary hepatocyte cultures shifted the phase of circahoralian rhythm of protein synthesis and hence, can be a factor synchronizing fluctuations in protein synthesis and rhythm organizer in the hepatocyte population. Blockade of melatonin receptors with luzindol...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine Vol. 149; no. 1; pp. 40 - 43
Main Authors: Brodsky, V. Y, Dubovaya, N. D, Zvezdina, T. K, Fateeva, V. I, Mal'chenko, L. A
Format: Journal Article
Language:English
Published: Boston Boston : Springer US 01-07-2010
Springer US
Springer
Springer Nature B.V
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
cell-cell interactions
Cells, Cultured
circahoralian biorhythms
Hepatocytes - metabolism
Internal Medicine
Laboratory Medicine
Melatonin
Melatonin - pharmacology
Pathology
Periodicity
Pharmacology and Toxicology
Protein biosynthesis
Protein Biosynthesis - drug effects
Protein Biosynthesis - physiology
protein synthesis
Rats
Receptors, Melatonin - antagonists & inhibitors
Tryptamines - pharmacology
circahoralian biorhythms
protein synthesis
melatonin
cell-cell interactions
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Summary:Melatonin (5 nM) added to medium with primary hepatocyte cultures shifted the phase of circahoralian rhythm of protein synthesis and hence, can be a factor synchronizing fluctuations in protein synthesis and rhythm organizer in the hepatocyte population. Blockade of melatonin receptors with luzindole (20 nM) arrested rhythm organization of protein synthesis by melatonin. Prospects of studying biochemical mechanisms of protein synthesis rhythm organization with other drugs (calcium agonists, similarly to melatonin) are discussed.
Bibliography:http://dx.doi.org/10.1007/s10517-010-0870-y
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-010-0870-y