Search Results - "Dubocovich, Margarita L"

MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective by Liu, Jiabei, Clough, Shannon J, Hutchinson, Anthony J, Adamah-Biassi, Ekue B, Popovska-Gorevski, Marina, Dubocovich, Margarita L

“…Melatonin, or 5-methoxy- N -acetyltryptamine, is synthesized and released by the pineal gland and locally in the retina following a circadian rhythm, with low…”
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Melatonin receptors: Role on sleep and circadian rhythm regulation by Dubocovich, Margarita L

“…Abstract The circadian release of the hormone melatonin is regulated by the suprachiasmatic nucleus (SCN), which feeds back into the nucleus to modulate sleep…”
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Update on melatonin receptors: IUPHAR Review 20 by Jockers, Ralf, Delagrange, Philippe, Dubocovich, Margarita L., Markus, Regina P., Renault, Nicolas, Tosini, Gianluca, Cecon, Erika, Zlotos, Darius P.

“…Melatonin receptors are seven transmembrane‐spanning proteins belonging to the GPCR superfamily. In mammals, two melatonin receptor subtypes exist ‐ MT1 and…”
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International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors by Dubocovich, Margarita L, Delagrange, Philippe, Krause, Diana N, Sugden, David, Cardinali, Daniel P, Olcese, James

“…The hormone melatonin (5-methoxy-N-acetyltryptamine) is synthesized primarily in the pineal gland and retina, and in several peripheral tissues and organs. In…”
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Virtual discovery of melatonin receptor ligands to modulate circadian rhythms by Stein, Reed M., Kang, Hye Jin, McCorvy, John D., Glatfelter, Grant C., Jones, Anthony J., Che, Tao, Slocum, Samuel, Huang, Xi-Ping, Savych, Olena, Moroz, Yurii S., Stauch, Benjamin, Johansson, Linda C., Cherezov, Vadim, Kenakin, Terry, Irwin, John J., Shoichet, Brian K., Roth, Bryan L., Dubocovich, Margarita L.

“…The neuromodulator melatonin synchronizes circadian rhythms and related physiological functions through the actions of two G-protein-coupled receptors: MT 1…”
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Functional MT1 and MT2 melatonin receptors in mammals by Dubocovich, Margarita L, Markowska, Magdalena

“…Melatonin, dubbed the hormone of darkness, is known to regulate a wide variety of physiological processes in mammals. This review describes well-defined…”
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Circadian modulation of neuroplasticity by melatonin: a target in the treatment of depression by Valdés‐Tovar, Marcela, Estrada‐Reyes, Rosa, Solís‐Chagoyán, Héctor, Argueta, Jesús, Dorantes‐Barrón, Ana María, Quero‐Chávez, Daniel, Cruz‐Garduño, Ricardo, Cercós, Montserrat G, Trueta, Citlali, Oikawa‐Sala, Julián, Dubocovich, Margarita L, Benítez‐King, Gloria

“…Mood disorders are a spectrum of neuropsychiatric disorders characterized by changes in the emotional state. In particular, major depressive disorder is…”
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Impact of endogenous melatonin on rhythmic behaviors, reproduction, and survival revealed in melatonin‐proficient C57BL/6J congenic mice by Zhang, Chongyang, Clough, Shannon J., Adamah‐Biassi, Ekue B., Sveinsson, Michele H., Hutchinson, Anthony J., Miura, Ikuo, Furuse, Tamio, Wakana, Shigeharu, Matsumoto, Yui K., Okanoya, Kazuo, Hudson, Randall L., Kato, Tadafumi, Dubocovich, Margarita L., Kasahara, Takaoki

“…The hormone melatonin is synthesized from serotonin by two enzymatic reactions (AANAT and ASMT/HIOMT) in the pineal gland following a circadian rhythm with low…”
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Melatonin potentiates running wheel-induced neurogenesis in the dentate gyrus of adult C3H/HeN mice hippocampus by Liu, Jiabei, Somera-Molina, Kathleen C., Hudson, Randall L., Dubocovich, Margarita L.

“…This study assessed the role of melatonin in modulating running wheel(RW)‐induced hippocampal neurogenesis in adult C3H/HeN mice. Chronic melatonin…”
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Antidepressant Low Doses of Ketamine and Melatonin in Combination Produce Additive Neurogenesis in Human Olfactory Neuronal Precursors by Estrada-Reyes, Rosa, Quero-Chávez, Daniel B, Alarcón-Elizalde, Salvador, Cercós, Montserrat G, Trueta, Citlali, Constantino-Jonapa, Luis A, Oikawa-Sala, Julián, Argueta, Jesús, Cruz-Garduño, Ricardo, Dubocovich, Margarita L, Benítez-King, Gloria A

“…Melatonin (MEL), an indolamine with diverse functions in the brain, has been shown to produce antidepressant-like effects, presumably through stimulating…”
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Low Doses of Ketamine and Melatonin in Combination Produce Additive Antidepressant-like Effects in Mice by Estrada-Reyes, Rosa, Quero-Chávez, Daniel B., Trueta, Citlali, Miranda, Armida, Valdés-Tovar, Marcela, Alarcón-Elizalde, Salvador, Oikawa-Sala, Julián, Argueta, Jesús, Constantino-Jonapa, Luis A., Muñoz-Estrada, Jesús, Dubocovich, Margarita L., Benítez-King, Gloria

“…Major depressive disorder is a disabling disease with the number of affected individuals increasing each year. Current antidepressant treatments take between…”
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The Timing of Melatonin Administration Is Crucial for Its Antidepressant-Like Effect in Mice by Estrada-Reyes, Rosa, Valdés-Tovar, Marcela, Arrieta-Baez, Daniel, Dorantes-Barrón, Ana María, Quero-Chávez, Daniel, Solís-Chagoyán, Héctor, Argueta, Jesús, Dubocovich, Margarita L, Benítez-King, Gloria

“…Melatonin is synthesized by the pineal gland with a circadian rhythm in synchrony with the environmental light/dark cycle. A gradual increase in circulating…”
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The Impact of School Daily Schedule on Adolescent Sleep by Hansen, Martha, Janssen, Imke, Schiff, Adam, Zee, Phyllis C, Dubocovich, Margarita L

“…This study was initiated to examine the impact of starting school on adolescent sleep, to compare weekday and weekend sleep times, and to attempt to normalize…”
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Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats by BLASK, David E, BRAINARD, George C, LYNCH, Darin T, ROLLAG, Mark D, ZALATAN, Frederick, DAUCHY, Robert T, HANIFIN, John P, DAVIDSON, Leslie K, KRAUSE, Jean A, SAUER, Leonard A, RIVERA-BERMUDEZ, Moises A, DUBOCOVICH, Margarita L, JASSER, Samar A

“…The increased breast cancer risk in female night shift workers has been postulated to result from the suppression of pineal melatonin production by exposure to…”
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Genetic deletion of the MT1 or MT2 melatonin receptors abrogates methamphetamine-induced reward in C3H/HeN mice by Clough, Shannon J, Hutchinson, Anthony J, Hudson, Randall L, Dubocovich, Margarita L

“…Abstract The drug of abuse methamphetamine (METH) is known for its ability to enhance reward responses. The rewarding properties of psychostimulants have been…”
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Role of MT1 melatonin receptors in methamphetamine-induced locomotor sensitization in C57BL/6 mice by Hutchinson, Anthony J., Ma, Jason, Liu, Jiabei, Hudson, Randall L., Dubocovich, Margarita L.

“…Rationale Melatonin modifies physiological and behavioral responses to psychostimulants, with the MT 1 and MT 2 melatonin receptors specifically implicated in…”
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Functional melatonin receptors in rat ovaries at various stages of the estrous cycle by Soares, Jr, Jose M, Masana, Monica I, Erşahin, Cağatay, Dubocovich, Margarita L

“…This study investigated the receptor mechanism(s) by which the hormone melatonin directly affects ovarian function. Expression of MT1 and MT2 melatonin…”
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Melatonin multifaceted pharmacological actions on melatonin receptors converging to abrogate COVID‐19 by Reynolds, Jessica L., Dubocovich, Margarita L.

“…Data indicate that controlling inflammatory responses to COVID‐19 may be as important as antiviral therapies or could be an important adjunctive approach…”
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Circadian periods of sensitivity for ramelteon on the onset of running-wheel activity and the peak of suprachiasmatic nucleus neuronal firing rhythms in C3H/HeN mice by Rawashdeh, Oliver, Hudson, Randall L, Stepien, Iwona, Dubocovich, Margarita L

“…Ramelteon, an MT(1)/MT(2) melatonin receptor agonist, is used for the treatment of sleep-onset insomnia and circadian sleep disorders. Ramelteon phase shifts…”
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Carbamate Insecticides Target Human Melatonin Receptors by Popovska-Gorevski, Marina, Dubocovich, Margarita L, Rajnarayanan, Rajendram V

“…Carbaryl (1-naphthyl methylcarbamate) and carbofuran (2,3-dihydro-2,2-dimethyl-7-benzofuranyl methylcarbamate) are among the most toxic insecticides,…”
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