Search Results - "Dubinett, Steven"

Functional profiling of circulating tumor cells with an integrated vortex capture and single-cell protease activity assay by Dhar, Manjima, Lam, Jeffrey Nam, Walser, Tonya, Dubinett, Steven M., Rettig, Matthew B., Di Carlo, Dino

“…Tumor cells are hypothesized to use proteolytic enzymes to facilitate invasion. Whether circulating tumor cells (CTCs) secrete these enzymes to aid metastasis…”
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CancerLocator: non-invasive cancer diagnosis and tissue-of-origin prediction using methylation profiles of cell-free DNA by Kang, Shuli, Li, Qingjiao, Chen, Quan, Zhou, Yonggang, Park, Stacy, Lee, Gina, Grimes, Brandon, Krysan, Kostyantyn, Yu, Min, Wang, Wei, Alber, Frank, Sun, Fengzhu, Dubinett, Steven M, Li, Wenyuan, Zhou, Xianghong Jasmine

“…We propose a probabilistic method, CancerLocator, which exploits the diagnostic potential of cell-free DNA by determining not only the presence but also the…”
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In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer by Momcilovic, Milica, Jones, Anthony, Bailey, Sean T., Waldmann, Christopher M., Li, Rui, Lee, Jason T., Abdelhady, Gihad, Gomez, Adrian, Holloway, Travis, Schmid, Ernst, Stout, David, Fishbein, Michael C., Stiles, Linsey, Dabir, Deepa V., Dubinett, Steven M., Christofk, Heather, Shirihai, Orian, Koehler, Carla M., Sadeghi, Saman, Shackelford, David B.

“…Mitochondria are essential regulators of cellular energy and metabolism, and have a crucial role in sustaining the growth and survival of cancer cells. A…”
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The Biology of Lung Cancer: Development of More Effective Methods for Prevention, Diagnosis, and Treatment by Salehi-Rad, Ramin, Li, Rui, Paul, Manash K, Dubinett, Steven M, Liu, Bin

“…Lung cancer is a heterogeneous disease with abundant genomic alterations. Chronic dysregulated airway inflammation facilitates lung tumorigenesis. In contrast,…”
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Lung Cancer and Immunity Markers by Lim, Raymond J, Liu, Bin, Krysan, Kostyantyn, Dubinett, Steven M

“…An in-depth understanding of lung cancer biology and mechanisms of tumor progression has facilitated significant advances in the treatment of lung cancer…”
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Sodium-glucose transporter 2 is a diagnostic and therapeutic target for early-stage lung adenocarcinoma by Scafoglio, Claudio R, Villegas, Brendon, Abdelhady, Gihad, Bailey, Sean T, Liu, Jie, Shirali, Aditya S, Wallace, W Dean, Magyar, Clara E, Grogan, Tristan R, Elashoff, David, Walser, Tonya, Yanagawa, Jane, Aberle, Denise R, Barrio, Jorge R, Dubinett, Steven M, Shackelford, David B

“…The diagnostic definition of indeterminate lung nodules as malignant or benign poses a major challenge for clinicians. We discovered a potential marker, the…”
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Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells by Dost, Antonella F.M., Moye, Aaron L., Vedaie, Marall, Tran, Linh M., Fung, Eileen, Heinze, Dar, Villacorta-Martin, Carlos, Huang, Jessie, Hekman, Ryan, Kwan, Julian H., Blum, Benjamin C., Louie, Sharon M., Rowbotham, Samuel P., Sainz de Aja, Julio, Piper, Mary E., Bhetariya, Preetida J., Bronson, Roderick T., Emili, Andrew, Mostoslavsky, Gustavo, Fishbein, Gregory A., Wallace, William D., Krysan, Kostyantyn, Dubinett, Steven M., Yanagawa, Jane, Kotton, Darrell N., Kim, Carla F.

“…Mutant KRAS is a common driver in epithelial cancers. Nevertheless, molecular changes occurring early after activation of oncogenic KRAS in epithelial cells…”
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Inhibition of Granulocytic Myeloid-Derived Suppressor Cells Overcomes Resistance to Immune Checkpoint Inhibition in LKB1-Deficient Non-Small Cell Lung Cancer by Li, Rui, Salehi-Rad, Ramin, Crosson, William, Momcilovic, Milica, Lim, Raymond J, Ong, Stephanie L, Huang, Zi Ling, Zhang, Tianhao, Abascal, Jensen, Dumitras, Camelia, Jing, Zhe, Park, Stacy J, Krysan, Kostyantyn, Shackelford, David B, Tran, Linh M, Liu, Bin, Dubinett, Steven M

“…LKB1 inactivating mutations are commonly observed in patients with KRAS-mutant non-small cell lung cancer (NSCLC). Although treatment of NSCLC with immune…”
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Understanding the Hurdles in Lung Cancer Immunotherapy in the Context of Chronic Obstructive Pulmonary Disease by Salehi-Rad, Ramin, Dubinett, Steven M

“…Patients with COPD have a greater risk of developing lung cancer, independently of the risk from cigarette smoke exposure (16). Molecular determinants of…”
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The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma by Momcilovic, Milica, Bailey, Sean T., Lee, Jason T., Fishbein, Michael C., Braas, Daniel, Go, James, Graeber, Thomas G., Parlati, Francesco, Demo, Susan, Li, Rui, Walser, Tonya C., Gricowski, Michael, Shuman, Robert, Ibarra, Julio, Fridman, Deborah, Phelps, Michael E., Badran, Karam, St. John, Maie, Bernthal, Nicholas M., Federman, Noah, Yanagawa, Jane, Dubinett, Steven M., Sadeghi, Saman, Christofk, Heather R., Shackelford, David B.

“…Altered metabolism is a hallmark of cancer growth, forming the conceptual basis for development of metabolic therapies as cancer treatments. We performed…”
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Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions by Beane, Jennifer E., Mazzilli, Sarah A., Campbell, Joshua D., Duclos, Grant, Krysan, Kostyantyn, Moy, Christopher, Perdomo, Catalina, Schaffer, Michael, Liu, Gang, Zhang, Sherry, Liu, Hanqiao, Vick, Jessica, Dhillon, Samjot S., Platero, Suso J., Dubinett, Steven M., Stevenson, Christopher, Reid, Mary E., Lenburg, Marc E., Spira, Avrum E.

“…Bronchial premalignant lesions (PMLs) are precursors of lung squamous cell carcinoma, but have variable outcome, and we lack tools to identify and treat PMLs…”
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Genomic Landscape of Atypical Adenomatous Hyperplasia Reveals Divergent Modes to Lung Adenocarcinoma by Sivakumar, Smruthy, Lucas, F Anthony San, McDowell, Tina L, Lang, Wenhua, Xu, Li, Fujimoto, Junya, Zhang, Jianjun, Futreal, P Andrew, Fukuoka, Junya, Yatabe, Yasushi, Dubinett, Steven M, Spira, Avrum E, Fowler, Jerry, Hawk, Ernest T, Wistuba, Ignacio I, Scheet, Paul, Kadara, Humam

“…There is a dearth of knowledge about the pathogenesis of premalignant lung lesions, especially for atypical adenomatous hyperplasia (AAH), the only known…”
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Cost-effective methylome sequencing of cell-free DNA for accurately detecting and locating cancer by Stackpole, Mary L., Zeng, Weihua, Li, Shuo, Liu, Chun-Chi, Zhou, Yonggang, He, Shanshan, Yeh, Angela, Wang, Ziye, Sun, Fengzhu, Li, Qingjiao, Yuan, Zuyang, Yildirim, Asli, Chen, Pin-Jung, Winograd, Paul, Tran, Benjamin, Lee, Yi-Te, Li, Paul Shize, Noor, Zorawar, Yokomizo, Megumi, Ahuja, Preeti, Zhu, Yazhen, Tseng, Hsian-Rong, Tomlinson, James S., Garon, Edward, French, Samuel, Magyar, Clara E., Dry, Sarah, Lajonchere, Clara, Geschwind, Daniel, Choi, Gina, Saab, Sammy, Alber, Frank, Wong, Wing Hung, Dubinett, Steven M., Aberle, Denise R., Agopian, Vatche, Han, Steven-Huy B., Ni, Xiaohui, Li, Wenyuan, Zhou, Xianghong Jasmine

“…Early cancer detection by cell-free DNA faces multiple challenges: low fraction of tumor cell-free DNA, molecular heterogeneity of cancer, and sample sizes…”
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Immune evasion in HPV⁻ head and neck precancer–cancer transition is driven by an aneuploid switch involving chromosome 9p loss by William, William N., Zhao, Xin, Bianchi, Joy J., Lin, Heather Y., Cheng, Pan, Lee, J. Jack, Carter, Hannah, Alexandrov, Ludmil B., Abraham, Jim P., Spetzler, David B., Dubinett, Steven M., Cleveland, Don W., Cavenee, Webster, Davoli, Teresa, Lippman, Scott M.

“…An aneuploid-immune paradox encompasses somatic copy-number alterations (SCNAs), unleashing a cytotoxic response in experimental precancer systems, while…”
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The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of non-small cell lung cancer (NSCLC) by Brahmer, Julie R, Govindan, Ramaswamy, Anders, Robert A, Antonia, Scott J, Sagorsky, Sarah, Davies, Marianne J, Dubinett, Steven M, Ferris, Andrea, Gandhi, Leena, Garon, Edward B, Hellmann, Matthew D, Hirsch, Fred R, Malik, Shakuntala, Neal, Joel W, Papadimitrakopoulou, Vassiliki A, Rimm, David L, Schwartz, Lawrence H, Sepesi, Boris, Yeap, Beow Yong, Rizvi, Naiyer A, Herbst, Roy S

“…Lung cancer is the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) accounting for over 85% of all cases. Until…”
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Phase I Trial of Intratumoral Injection of CCL21 Gene-Modified Dendritic Cells in Lung Cancer Elicits Tumor-Specific Immune Responses and CD8 + T-cell Infiltration by Lee, Jay M, Lee, Mi-Heon, Garon, Edward, Goldman, Jonathan W, Salehi-Rad, Ramin, Baratelli, Felicita E, Schaue, Dörthe, Wang, Gerald, Rosen, Fran, Yanagawa, Jane, Walser, Tonya C, Lin, Ying, Park, Stacy J, Adams, Sharon, Marincola, Francesco M, Tumeh, Paul C, Abtin, Fereidoun, Suh, Robert, Reckamp, Karen L, Lee, Gina, Wallace, William D, Lee, Sarah, Zeng, Gang, Elashoff, David A, Sharma, Sherven, Dubinett, Steven M

“…A phase I study was conducted to determine safety, clinical efficacy, and antitumor immune responses in patients with advanced non-small cell lung carcinoma…”
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The Single-Cell Immunogenomic Landscape of B and Plasma Cells in Early-Stage Lung Adenocarcinoma by Hao, Dapeng, Han, Guangchun, Sinjab, Ansam, Gomez-Bolanos, Lorena Isabel, Lazcano, Rossana, Serrano, Alejandra, Hernandez, Sharia D, Dai, Enyu, Cao, Xuanye, Hu, Jian, Dang, Minghao, Wang, Ruiping, Chu, Yanshuo, Song, Xingzhi, Zhang, Jianhua, Parra, Edwin R, Wargo, Jennifer A, Swisher, Stephen G, Cascone, Tina, Sepesi, Boris, Futreal, Andrew P, Li, Mingyao, Dubinett, Steven M, Fujimoto, Junya, Solis Soto, Luisa M, Wistuba, Ignacio I, Stevenson, Christopher S, Spira, Avrum, Shalapour, Shabnam, Kadara, Humam, Wang, Linghua

“…Tumor-infiltrating B and plasma cells (TIB) are prevalent in lung adenocarcinoma (LUAD); however, they are poorly characterized. We performed paired…”
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Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer by Momcilovic, Milica, Bailey, Sean T., Lee, Jason T., Fishbein, Michael C., Magyar, Clara, Braas, Daniel, Graeber, Thomas, Jackson, Nicholas J., Czernin, Johannes, Emberley, Ethan, Gross, Matthew, Janes, Julie, Mackinnon, Andy, Pan, Alison, Rodriguez, Mirna, Works, Melissa, Zhang, Winter, Parlati, Francesco, Demo, Susan, Garon, Edward, Krysan, Kostyantyn, Walser, Tonya C., Dubinett, Steven M., Sadeghi, Saman, Christofk, Heather R., Shackelford, David B.

“…Cancer cells exhibit increased use of nutrients, including glucose and glutamine, to support the bioenergetic and biosynthetic demands of proliferation. We…”
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Drug Development for Metastasis Prevention by Fontebasso, Yari, Dubinett, Steven M

“…Metastatic disease is responsible for 90% of death from solid tumors. However, only a minority of metastasis-specific targets has been exploited…”
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Spatial mapping of mitochondrial networks and bioenergetics in lung cancer by Han, Mingqi, Bushong, Eric A., Segawa, Mayuko, Tiard, Alexandre, Wong, Alex, Brady, Morgan R., Momcilovic, Milica, Wolf, Dane M., Zhang, Ralph, Petcherski, Anton, Madany, Matthew, Xu, Shili, Lee, Jason T., Poyurovsky, Masha V., Olszewski, Kellen, Holloway, Travis, Gomez, Adrian, John, Maie St, Dubinett, Steven M., Koehler, Carla M., Shirihai, Orian S., Stiles, Linsey, Lisberg, Aaron, Soatto, Stefano, Sadeghi, Saman, Ellisman, Mark H., Shackelford, David B.

“…Mitochondria are critical to the governance of metabolism and bioenergetics in cancer cells 1 . The mitochondria form highly organized networks, in which their…”
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