Search Results - "Dubiel, W"

The multicatalytic and 26 S proteases by RECHSTEINER, M, HOFFMAN, L, DUBIEL, W

“…Two large, multisubunit proteases are abundant constituents in the cytosol/nuclear compartments of eucaryotic cells. Among many names proposed for the smaller…”
Get full text

Molecular cloning and expression of a gamma-interferon-inducible activator of the multicatalytic protease by REALINI, C, DUBIEL, W, PRATT, G, FERRELL, K, RECHSTEINER, M

“…The multicatalytic protease (MCP) can be activated by two distinct multisubunit complexes. One is the regulatory component of the 26 S protease, which contains…”
Get full text

Unified nomenclature for the COP9 signalosome and its subunits: an essential regulator of development by Deng, X W, Dubiel, W, Wei, N, Hofmann, K, Mundt, K, Colicelli, J, Kato, J, Naumann, M, Segal, D, Seeger, M, Carr, A, Glickman, M, Chamovitz, D A

Get full text

Purification of an 11 S regulator of the multicatalytic protease by DUBIEL, W, PRATT, G, FERRELL, K, RECHSTEINER, M

“…We have identified and purified a protein complex from human red blood cells that activates the multicatalytic protease (MCP). The complex, which we call the…”
Get full text

Isoform-specific increase of spastin stability by N-terminal missense variants including intragenic modifiers of SPG4 hereditary spastic paraplegia by Schickel, J., Pamminger, T., Ehrsam, A., Münch, S., Huang, X., Klopstock, T., Kurlemann, G., Hemmerich, P., Dubiel, W., Deufel, T., Beetz, C.

“…Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder selectively affecting axons of spinal cord motoneurons. Classical mutations in the most…”
Get full text

The constitutive photomorphogenesis 9 signalosome directs vascular endothelial growth factor production in tumor cells by POLLMANN, Christian, XIAOHUA HUANG, MALL, Julian, BECH-OTSCHIR, Dawadschargal, NAUMANN, Michael, DUBIEL, Wolfgang

“…Angiogenesis is a prerequisite for solid tumor growth and metastasis. Elucidation of the signaling pathways that control tumor angiogenesis constitutes the…”
Get full text

Subunit 4 of the 26 S protease is a member of a novel eukaryotic ATPase family by DUBIEL, W, FERRELL, K, PRATT, G, RECHSTEINER, M

“…Ubiquitinated proteins are degraded by a 26 S ATP-dependent protease. SDS-polyacrylamide gel electrophoresis analysis of the purified 26 S enzyme reveals more…”
Get full text

Ubiquitin pathway: Another link in the polyubiquitin chain? by Dubiel, Wolfgang, Gordon, Colin

“…Polyubiquitin has long been recognised as an intracellular signal. It now appears that different lysine linkages between the ubiquitin moieties are recognised…”
Get full text

Structural valve deterioration in mitral replacement surgery: Comparison of carpentier-edwards supra-annular porcine and perimount pericardial bioprostheses by Eric Jamieson, W.R., Marchand, Michel A., Pelletier, Conrad L., Norton, Robert, Pellerin, Michel, Dubiel, Thomas W., Aupart, Michel R., Daenen, Willem J., Holden, Michael P., David, Tirone E., Ryba, Eke A., Anderson, William N.

“…Background: Bioprostheses preserved with glutaraldehyde, both porcine and pericardial, have been available as second-generation prostheses for valve…”
Get full text

Unified nomenclature for the COP9 signalosome and its subunits: an essential regulator of development by Deng, X-W, Dubiel, W, Wei, N, Hofmann, K, Mundt, K

Get full text

Honokiol, a Small Molecular Weight Natural Product, Inhibits Angiogenesis in Vitro and Tumor Growth in Vivo by Bai, Xianhe, Cerimele, Francesca, Ushio-Fukai, Masuko, Waqas, Muhammad, Campbell, Paul M., Govindarajan, Baskaran, Der, Channing J., Battle, Traci, Frank, David A., Ye, Keqiang, Murad, Emma, Dubiel, Wolfgang, Soff, Gerald, Arbiser, Jack L.

“…Natural products comprise a major source of small molecular weight angiogenesis inhibitors. We have used the transformed endothelial cell line SVR as an…”
Get full text

Evidence for a Novel ATP-Dependent Protease from the Rat Liver Mitochondrial Intermembrane Space: Purification and Characterisation by Sitte, Nicolle, Dubiel, Wolfgang, Kloetzel, Peter-Michael

“…An ATP-dependent protease in the intermembrane space of rat liver mitochondria, MISPI (mitochondrial intermembrane space protease), was partially purified and…”
Get full text

Caspase Activation Inhibits Proteasome Function during Apoptosis by Sun, Xiao-Ming, Butterworth, Michael, MacFarlane, Marion, Dubiel, Wolfgang, Ciechanover, Aaron, Cohen, Gerald M

“…The ubiquitin/proteasome system regulates protein turnover by degrading polyubiquitinated proteins. To date, all studies on the relationship of apoptosis and…”
Get full text

COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system by Bech-Otschir, Dawadschargal, Kraft, Regine, Huang, Xiaohua, Henklein, Peter, Kapelari, Barbara, Pollmann, Christian, Dubiel, Wolfgang

“…In higher eukaryotic cells, the p53 protein is degraded by the ubiquitin–26S proteasome system mediated by Mdm2 or the human papilloma virus E6 protein. Here…”
Get full text

Linear collagen naevus: an unusual connective tissue disorder by Dubiel, Walter, Kiehlmann, Ingomar, Happle, Rudolf

Get full text

Proteolysis of mitochondria in reticulocytes during maturation is ubiquitin-dependent and is accompanied by a high rate of ATP hydrolysis by Rapoport, S., Dubiel, W., Müller, M.

“…The ATP-dependent breakdown of mitochondria-containing stroma proceeds via the ubiquitin-requiring pathway. The proteolysis is linked to a large ATP-cleaved…”
Get full text

Fission Yeast COP9/Signalosome Suppresses Cullin Activity through Recruitment of the Deubiquitylating Enzyme Ubp12p by Zhou, Chunshui, Wee, Susan, Rhee, Edward, Naumann, Michael, Dubiel, Wolfgang, Wolf, Dieter A

“…The COP9/signalosome (CSN) is known to remove the stimulatory NEDD8 modification from cullins. The activity of the fission yeast cullins Pcu1p and Pcu3p is…”
Get full text

Pericarbon pericardial valve prosthesis: midterm results of the aortic valve replacement by Borowiec, J W, Dubiel, T W, Hansson, H E, Landelius, J, Nyström, S O

“…This clinical study was undertaken to verify the encouraging results of experimental studies regarding a new pericardial bioprosthesis. From May 1989 to…”
Get more information

Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome by Uhle, Stefan, Medalia, Ohad, Waldron, Richard, Dumdey, Renate, Henklein, Peter, Bech-Otschir, Dawadschargal, Huang, Xiaohua, Berse, Matthias, Sperling, Joseph, Schade, Rüdiger, Dubiel, Wolfgang

“…The COP9 signalosome (CSN) purified from human erythrocytes possesses kinase activity that phosphoryl ates proteins such as c‐Jun and p53 with consequence for…”
Get full text

The Zinc Finger of the CSN-Associated Deubiquitinating Enzyme USP15 Is Essential to Rescue the E3 Ligase Rbx1 by Hetfeld, Bettina K.J., Helfrich, Annett, Kapelari, Barbara, Scheel, Hartmut, Hofmann, Kay, Guterman, Adi, Glickman, Michael, Schade, Rüdiger, Kloetzel, Peter-Michael, Dubiel, Wolfgang

“…The COP9 signalosome (CSN) is a conserved protein complex found in all eukaryotic cells and involved in the regulation of the ubiquitin (Ub)/26S proteasome…”
Get full text