Biochemical strategies of E3 ubiquitin ligases target viruses in critical diseases

Viruses are known to cause various diseases in human and also infect other species such as animal plants, fungi, and bacteria. Replication of viruses depends upon their interaction with hosts. Human cells are prone to such unwanted viral infections. Disintegration and reconstitution require host mac...

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Bibliographic Details
Published in:	Journal of cellular biochemistry Vol. 123; no. 2; pp. 161 - 182
Main Authors:	Dubey, Ankur R., Jagtap, Yuvraj A., Kumar, Prashant, Patwa, Som M., Kinger, Sumit, Kumar, Amit, Singh, Sarika, Prasad, Amit, Jana, Nihar R., Mishra, Amit
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01-02-2022
Subjects:	Biodegradation Cell Transformation, Viral - physiology coronavirus infection COVID-19 - drug therapy Cullin Proteins - physiology Deoxyribonucleic acid Disintegration DNA E3 ubiquitin ligases Endosomes - virology Host-Pathogen Interactions Humans Immunity, Innate Infections Inflammation - enzymology Inflammation - virology influenza infection Intracellular Macromolecules Neoplasms - enzymology Neoplasms - virology NF‐κB activation Oncogenic Viruses - physiology Propagation Proteasome Endopeptidase Complex - metabolism Proteasomes Proteins Proteolysis Substrates Tripartite Motif Proteins - physiology Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - antagonists & inhibitors Ubiquitin-Protein Ligases - physiology viral encephalitis Viral infections viral oncogenesis Viral Proteins - physiology Virus Diseases - enzymology Virus Diseases - immunology Virus Diseases - virology Virus Replication - drug effects Virus Replication - physiology Viruses coronavirus infection NF-κB activation viral oncogenesis influenza infection viral encephalitis E3 ubiquitin ligases
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Summary:	Viruses are known to cause various diseases in human and also infect other species such as animal plants, fungi, and bacteria. Replication of viruses depends upon their interaction with hosts. Human cells are prone to such unwanted viral infections. Disintegration and reconstitution require host machinery and various macromolecules like DNA, RNA, and proteins are invaded by viral particles. E3 ubiquitin ligases are known for their specific function, that is, recognition of their respective substrates for intracellular degradation. Still, we do not understand how ubiquitin proteasome system‐based enzymes E3 ubiquitin ligases do their functional interaction with different viruses. Whether E3 ubiquitin ligases help in the elimination of viral components or viruses utilize their molecular capabilities in their intracellular propagation is not clear. The first time our current article comprehends fundamental concepts and new insights on the different viruses and their interaction with various E3 Ubiquitin Ligases. In this review, we highlight the molecular pathomechanism of viruses linked with E3 Ubiquitin Ligases dependent mechanisms. An enhanced understanding of E3 Ubiquitin Ligase‐mediated removal of viral proteins may open new therapeutic strategies against viral infections.
ISSN:	0730-2312 1097-4644
DOI:	10.1002/jcb.30143