Search Results - "Dubern, Jean‐Frédéric"

AbaM Regulates Quorum Sensing, Biofilm Formation, and Virulence in Acinetobacter baumannii by López-Martín, Mario, Dubern, Jean-Frédéric, Alexander, Morgan R, Williams, Paul

“…possesses a single divergent / -type quorum-sensing (QS) locus named / This locus also contains a third gene located between and , which we term , that codes…”
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Validating a Predictive Structure–Property Relationship by Discovery of Novel Polymers which Reduce Bacterial Biofilm Formation by Dundas, Adam A., Sanni, Olutoba, Dubern, Jean‐Frédéric, Dimitrakis, Georgios, Hook, Andrew L., Irvine, Derek J., Williams, Paul, Alexander, Morgan R.

“…Synthetic materials are an everyday component of modern healthcare yet often fail routinely as a consequence of medical‐device‐centered infections. The…”
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Unravelling the Genome-Wide Contributions of Specific 2-Alkyl-4-Quinolones and PqsE to Quorum Sensing in Pseudomonas aeruginosa by Rampioni, Giordano, Falcone, Marilena, Heeb, Stephan, Frangipani, Emanuela, Fletcher, Matthew P, Dubern, Jean-Frédéric, Visca, Paolo, Leoni, Livia, Cámara, Miguel, Williams, Paul

“…The pqs quorum sensing (QS) system is crucial for Pseudomonas aeruginosa virulence both in vitro and in animal models of infection and is considered an ideal…”
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A Pseudomonas aeruginosa PQS quorum-sensing system inhibitor with anti-staphylococcal activity sensitizes polymicrobial biofilms to tobramycin by Murray, Ewan J, Dubern, Jean-Frédéric, Chan, Weng C, Chhabra, Siri Ram, Williams, Paul

“…As single- and mixed-species biofilms, Staphylococcus aureus and Pseudomonas aeruginosa cause difficult-to-eradicate chronic infections. In P. aeruginosa,…”
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In Silico and in Vitro-Guided Identification of Inhibitors of Alkylquinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa by Soukarieh, Fadi, Vico Oton, Eduard, Dubern, Jean-Frédéric, Gomes, Janice, Halliday, Nigel, de Pilar Crespo, Maria, Ramírez-Prada, Jonathan, Insuasty, Braulio, Abonia, Rodrigo, Quiroga, Jairo, Heeb, Stephan, Williams, Paul, Stocks, Michael J, Cámara, Miguel

“…is a major opportunistic pathogen in cystic fibrosis, wound and nosocomial infections, posing a serious burden to public health, due to its antibiotic…”
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Integrated whole‐genome screening for Pseudomonas aeruginosa virulence genes using multiple disease models reveals that pathogenicity is host specific by Dubern, Jean‐Frédéric, Cigana, Cristina, De Simone, Maura, Lazenby, James, Juhas, Mario, Schwager, Stephan, Bianconi, Irene, Döring, Gerd, Eberl, Leo, Williams, Paul, Bragonzi, Alessandra, Cámara, Miguel

“…Pseudomonas aeruginosa is a multi‐host opportunistic pathogen causing a wide range of diseases because of the armoury of virulence factors it produces, and it…”
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Design, Synthesis, and Evaluation of New 1H‑Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections by Soukarieh, Fadi, Mashabi, Alaa, Richardson, William, Oton, Eduard Vico, Romero, Manuel, Dubern, Jean-Frédéric, Robertson, Shaun N., Lucanto, Simone, Markham-Lee, Zoe, Sou, Tomás, Kukavica-Ibrulj, Irena, Levesque, Roger C., Bergstrom, Christel A. S., Halliday, Nigel, Kellam, Barrie, Emsley, Jonas, Heeb, Stephan, Williams, Paul, Stocks, Michael J., Cámara, Miguel

“…Pseudomonas aeruginosa is one of the top priority pathogens that requires immediate attention according to the World Health Organisation (WHO). Due to the…”
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Growth rate and nutrient limitation as key drivers of extracellular quorum sensing signal molecule accumulation in Pseudomonas aeruginosa by Dubern, Jean-Frédéric, Halliday, Nigel, Cámara, Miguel, Winzer, Klaus, Barrett, David A, Hardie, Kim R, Williams, Paul

“…In , quorum sensing (QS) depends on an interconnected regulatory hierarchy involving the Las, Rhl and Pq systems, which are collectively responsible for the…”
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Achieving Microparticles with Cell‐Instructive Surface Chemistry by Using Tunable Co‐Polymer Surfactants by Dundas, Adam A., Cuzzucoli Crucitti, Valentina, Haas, Simon, Dubern, Jean‐Frédéric, Latif, Arsalan, Romero, Manuel, Sanni, Olutoba, Ghaemmaghami, Amir M., Williams, Paul, Alexander, Morgan R., Wildman, Ricky, Irvine, Derek J.

“…A flow‐focusing microfluidic device is used to produce functionalized monodisperse polymer particles with surface chemistries designed to control bacterial…”
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Predictive Molecular Design and Structure–Property Validation of Novel Terpene-Based, Sustainably Sourced Bacterial Biofilm-Resistant Materials by Cuzzucoli Crucitti, Valentina, Ilchev, Aleksandar, Moore, Jonathan C., Fowler, Harriet R., Dubern, Jean-Frédéric, Sanni, Olutoba, Xue, Xuan, Husband, Bethany K., Dundas, Adam A., Smith, Sean, Wildman, Joni L., Taresco, Vincenzo, Williams, Paul, Alexander, Morgan R., Howdle, Steven M., Wildman, Ricky D., Stockman, Robert A., Irvine, Derek J.

“…Presented in this work is the use of a molecular descriptor, termed the α parameter, to aid in the design of a series of novel, terpene-based, and sustainable…”
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Simultaneous quantitative profiling of N-acyl-l-homoserine lactone and 2-alkyl-4(1H)-quinolone families of quorum-sensing signaling molecules using LC-MS/MS by Ortori, Catharine A, Dubern, Jean-Frédéric, Chhabra, Siri Ram, Cámara, Miguel, Hardie, Kim, Williams, Paul, Barrett, David A

“…An LC-MS/MS method, using positive mode electrospray ionization, for the simultaneous, quantitative and targeted profiling of the N-acyl-l-homoserine lactone…”
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Real time monitoring of biofilm formation on coated medical devices for the reduction and interception of bacterial infections by Kurmoo, Yasin, Hook, Andrew L, Harvey, Daniel, Dubern, Jean-Frédéric, Williams, Paul, Morgan, Stephen P, Korposh, Serhiy, Alexander, Morgan R

“…Real time monitoring of bacterial attachment to medical devices provides opportunities to detect early biofilm formation and instigate appropriate…”
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Ink-jet 3D printing as a strategy for developing bespoke non-eluting biofilm resistant medical devices by He, Yinfeng, Luckett, Jeni, Begines, Belen, Dubern, Jean-Frédéric, Hook, Andrew L., Prina, Elisabetta, Rose, Felicity R.A.J., Tuck, Christopher J., Hague, Richard J.M., Irvine, Derek J., Williams, Paul, Alexander, Morgan R., Wildman, Ricky D.

“…Chronic infection as a result of bacterial biofilm formation on implanted medical devices is a major global healthcare problem requiring new biocompatible,…”
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NirA Is an Alternative Nitrite Reductase from Pseudomonas aeruginosa with Potential as an Antivirulence Target by Fenn, Samuel, Dubern, Jean-Frédéric, Cigana, Cristina, De Simone, Maura, Lazenby, James, Juhas, Mario, Schwager, Stephan, Bianconi, Irene, Döring, Gerd, Elmsley, Jonas, Eberl, Leo, Williams, Paul, Bragonzi, Alessandra, Cámara, Miguel

“…The opportunistic pathogen produces an arsenal of virulence factors causing a wide range of diseases in multiple hosts and is difficult to eradicate due to its…”
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The ppuI-rsaL-ppuR Quorum-Sensing System Regulates Biofilm Formation of Pseudomonas putida PCL1445 by Controlling Biosynthesis of the Cyclic Lipopeptides Putisolvins I and II by DUBEM, Jean-Frédéric, LUGTENBERG, Ben J. J, BLOEMBERG, Guido V

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Synthesis and cell-free cloning of DNA libraries using programmable microfluidics by Ben Yehezkel, Tuval, Rival, Arnaud, Raz, Ofir, Cohen, Rafael, Marx, Zipora, Camara, Miguel, Dubern, Jean-Frédéric, Koch, Birgit, Heeb, Stephan, Krasnogor, Natalio, Delattre, Cyril, Shapiro, Ehud

“…Microfluidics may revolutionize our ability to write synthetic DNA by addressing several fundamental limitations associated with generating novel genetic…”
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Regulation of GacA in Pseudomonas chlororaphis Strains Shows a Niche Specificity by Li, Jun, Yang, Yang, Dubern, Jean-Frédéric, Li, Hui, Halliday, Nigel, Chernin, Leonid, Gao, Kexiang, Cámara, Miguel, Liu, Xiaoguang

“…The GacS/GacA two-component system plays a central role in the regulation of a broad range of biological functions in many bacteria. In the biocontrol organism…”
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Simultaneous Tracking of Pseudomonas aeruginosa Motility in Liquid and at the Solid-Liquid Interface Reveals Differential Roles for the Flagellar Stators by Hook, Andrew L, Flewellen, James L, Dubern, Jean-Frédéric, Carabelli, Alessandro M, Zaid, Irwin M, Berry, Richard M, Wildman, Ricky D, Russell, Noah, Williams, Paul, Alexander, Morgan R

“…Bacteria sense chemicals, surfaces, and other cells and move toward some and away from others. Studying how single bacterial cells in a population move…”
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Discovery of a polymer resistant to bacterial biofilm, swarming, and encrustation by Dubern, Jean-Frédéric, Hook, Andrew L, Carabelli, Alessandro M, Chang, Chien-Yi, Lewis-Lloyd, Christopher A, Luckett, Jeni C, Burroughs, Laurence, Dundas, Adam A, Humes, David J, Irvine, Derek J, Alexander, Morgan R, Williams, Paul

“…Innovative approaches to prevent catheter-associated urinary tract infections (CAUTIs) are urgently required. Here, we describe the discovery of an acrylate…”
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Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices by He, Yinfeng, Abdi, Meisam, Trindade, Gustavo F., Begines, Belén, Dubern, Jean‐Frédéric, Prina, Elisabetta, Hook, Andrew L., Choong, Gabriel Y. H., Ledesma, Javier, Tuck, Christopher J., Rose, Felicity R. A. J., Hague, Richard J. M., Roberts, Clive J., De Focatiis, Davide S. A., Ashcroft, Ian A., Williams, Paul, Irvine, Derek J., Alexander, Morgan R., Wildman, Ricky D.

“…As the understanding of disease grows, so does the opportunity for personalization of therapies targeted to the needs of the individual. To bring about a step…”
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