Search Results - "Dube, Michael G"

Leptin gene transfer in the hypothalamus enhances longevity in adult monogenic mutant mice in the absence of circulating leptin by Boghossian, Stéphane, Ueno, Naohiko, Dube, Michael G, Kalra, Pushpa, Kalra, Satya

“…Abstract Leptin, a product of the ob gene, is a pleiotropic signal implicated in regulation of multiple physiological functions in the periphery and centrally,…”
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Leptin Modulates Orexigenic Effects of Ghrelin and Attenuates Adiponectin and Insulin Levels and Selectively the Dark-Phase Feeding as Revealed by Central Leptin Gene Therapy by Ueno, Naohiko, Dube, Michael G, Inui, Akio, Kalra, Pushpa S, Kalra, Satya P

“…We tested the hypothesis that leptin acts centrally and peripherally by different mechanisms to control peripheral hormones that normally regulate weight…”
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Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis by Malhotra, Ashwani, Vashistha, Himanshu, Yadav, Virendra S, Dube, Michael G, Kalra, Satya P, Abdellatif, Maha, Meggs, Leonard G

“…Apoptotic myocyte cell death, diastolic dysfunction, and progressive deterioration in left ventricular pump function characterize the clinical course of…”
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Leptin Expression in Hypothalamic PVN Reverses Dietary Obesity and Hyperinsulinemia but Stimulates Ghrelin by Bagnasco, Michela, Dube, Michael G., Katz, Adi, Kalra, Pushpa S., Kalra, Satya P.

“…Objective: In order to circumvent the multiple peripheral effects of hyperleptinemia and leptin resistance, the efficacy of leptin transgene expression in the…”
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High-fat Diet-induced Ultradian Leptin and Insulin Hypersecretion are Absent in Obesity-resistant Rats by Otukonyong, Effiong E, Dube, Michael G, Torto, Rita, Kalra, Pushpa S, Kalra, Satya P

“…OBJECTIVE: Sprague-Dawley rats fed a high-fat diet (HFD) are either obesity prone (OP) or obesity resistant (OR). We tested the hypothesis that differences in…”
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Central leptin differentially modulates ultradian secretory patterns of insulin, leptin and ghrelin independent of effects on food intake and body weight by Otukonyong, Effiong E., Dube, Michael G., Torto, Rita, Kalra, Pushpa S., Kalra, Satya P.

“…We tested the hypothesis that leptin acts centrally to differentially modulate the ultradian communication of leptin, insulin and ghrelin with the…”
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Low abundance of NPY in the hypothalamus can produce hyperphagia and obesity by Dube, Michael G., Kalra, Satya P., Kalra, Pushpa S.

“…States of increased metabolic demand are associated with up-regulation of NPY and hyperphagia. However, we present some instances of hyperphagia in which NPY…”
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Evidence of NPY Y5 receptor involvement in food intake elicited by orexin A in sated rats by Dube, Michael G, Horvath, Tamas L, Kalra, Pushpa S, Kalra, Satya P

“…Intracerebroventricular (icv) injections of orexin A stimulate feeding in sated rats. Since neuropeptide Y is a potent orexigenic peptide and orexin-containing…”
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Leptin increases osteoblast-specific osteocalcin release through a hypothalamic relay by Kalra, Satya P., Dube, Michael G., Iwaniec, Urszula T.

“…Enhanced long-term expression of leptin by gene therapy selectively in the hypothalamus, without leakage to the systemic circulation, abrogated skeletal…”
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Leptin and ciliary neurotropic factor (CNTF) inhibit fasting-induced suppression of luteinizing hormone release in rats: role of neuropeptide Y by Kalra, Satya P, Xu, Bin, Dube, Michael G, Moldawer, Lyle L, David Martin, Kalra, Pushpa S

“…Periods of chronic undernutrition and short periods of fasting suppress pituitary luteinizing hormone (LH) secretion and upregulate hypothalamic neuropeptide Y…”
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Increased leptin expression selectively in the hypothalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice by Dube, Michael G., Torto, Rita, Kalra, Satya P.

“…Low-grade systemic inflammation, as indicated by increased circulating levels of inflammatory markers CRP and IL-6, is linked to increased risks for…”
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Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action by Dube, Michael G, Kalra, Satya P, Kalra, Pushpa S

“…Orexin A and B, a recently identified pair of neuropeptides, are produced in perikarya located in the lateral and perifornical hypothalamus (LH and PFH)…”
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Rhythmic, reciprocal ghrelin and leptin signaling: new insight in the development of obesity by Kalra, Satya P, Bagnasco, Michela, Otukonyong, Effiong E, Dube, Michael G, Kalra, Pushpa S

“…The hypothalamus integrates metabolic, neural and hormonal signals to evoke an intermittent appetitive drive in the daily management of energy homeostasis…”
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Long-term suppression of weight gain, adiposity, and serum insulin by central leptin gene therapy in prepubertal rats: Effects on serum ghrelin and appetite-regulating genes by BERETTA, Elena, DUBE, Michael G, KALRA, Pushpa S, KALRA, Satya P

“…Intracerebroventricular administration of recombinant adeno-associated virus (rAAV) encoding the rat leptin gene (rAAV-lep) to 24-d-old female and male rats…”
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Central Leptin Gene Therapy Blocks Ovariectomy-Induced Adiposity by Torto, Rita, Boghossian, Stéphane, Dube, Michael G., Kalra, Pushpa S., Kalra, Satya P.

“…Objective: In this study, we tested the hypothesis that insufficiency of leptin restraint in the hypothalamus is responsible for promoting weight gain and…”
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Hypothalamic clamp on insulin release by leptin-transgene expression by Boghossian, Stéphane, Dube, Michael G., Torto, Rita, Kalra, Pushpa S., Kalra, Satya P.

“…The effects of sustained leptin action locally in the hypothalamus on the functional link between fat accrual and insulin secretion after chronic high fat diet…”
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Central leptin gene therapy blocks high-fat diet-induced weight gain, hyperleptinemia, and hyperinsulinemia increase in serum ghrelin levels by DUBE, Michael G, BERETTA, Elena, DHILLON, Harveen, UENO, Naohiko, KALRA, Pushpa S, KALRA, Satya P

“…Recombinant adeno-associated virus (rAAV), encoding either rat leptin (rAAV-lep) or green fluorescent protein (rAAV-GFP, control), was injected…”
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Increased Leptin Expression in the Dorsal Vagal Complex Suppresses Adiposity without Affecting Energy Intake and Metabolic Hormones by Boghossian, Stéphane, Lecklin, Anne, Dube, Michael G., Kalra, Pushpa S., Kalra, Satya P.

“…Objective: Increased leptin transgene expression locally in hypothalamic sites suppresses weight and energy intake, enhances thermogenic energy expenditure,…”
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The hypothalamic paraventricular nucleus is not essential for orexigenic NPY or anorexigenic melanocortin action by Dube, Michael G., Kalra, Satya P., Kalra, Pushpa S.

“…Bilateral electrolytic lesions of the paraventricular nucleus of the hypothalamus (PVN) produce hyperphagia with excess weight gain. The orexigenic…”
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Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight by Kalra, Satya P., Dube, Michael G., Pu, Shuye, Xu, Bin, Horvath, Tamas L., Kalra, Pushpa S.

“…Various aspects of the complex spatio-temporal patterning of hypothalamic signaling that leads to the development of synchronized nocturnal feeding in the rat…”
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