Gloriosa superba Mediated Synthesis of Platinum and Palladium Nanoparticles for Induction of Apoptosis in Breast Cancer

Gloriosa superba Mediated Synthesis of Platinum and Palladium Nanoparticles for Induction of Apoptosis in Breast Cancer

Green chemistry approaches for designing therapeutically significant nanomedicine have gained considerable attention in the past decade. Herein, we report for the first time on anticancer potential of phytogenic platinum nanoparticles (PtNPs) and palladium nanoparticles (PdNPs) using a medicinal pla...

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Published in:Bioinorganic chemistry and applications Vol. 2018; no. 2018; pp. 1 - 9
Main Authors: Ghosh, Sougata, Bellare, Jayesh, Parihar, Vijay Singh, Dubal, Dnyanesh S., Tomar, Geetanjali, Patil, Saniya, Mahajan, Ketakee, Joshi, Komal A., Rokade, Shalaka S., Kitture, Rohini
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 01-01-2018
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Subjects:
Anticancer properties
Apoptosis
Biosynthesis
Breast cancer
Cancer
Cancer therapies
Chemistry
Flow cytometry
Herbal medicine
Hydrogenation
Nanoparticles
Nanotechnology
Organic chemistry
Palladium
Photon correlation spectroscopy
Platinum
Quantum dots
Synthesis
Transmission electron microscopy
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Summary:Green chemistry approaches for designing therapeutically significant nanomedicine have gained considerable attention in the past decade. Herein, we report for the first time on anticancer potential of phytogenic platinum nanoparticles (PtNPs) and palladium nanoparticles (PdNPs) using a medicinal plant Gloriosa superba tuber extract (GSTE). The synthesis of the nanoparticles was completed within 5 hours at 100°C which was confirmed by development of dark brown and black colour for PtNPs and PdNPs, respectively, along with enhancement of the peak intensity in the UV-visible spectra. High-resolution transmission electron microscopy (HRTEM) showed that the monodispersed spherical nanoparticles were within a size range below 10 nm. Energy dispersive spectra (EDS) confirmed the elemental composition, while dynamic light scattering (DLS) helped to evaluate the hydrodynamic size of the particles. Anticancer activity against MCF-7 (human breast adenocarcinoma) cell lines was evaluated using MTT assay, flow cytometry, and confocal microscopy. PtNPs and PdNPs showed 49.65 ± 1.99% and 36.26 ± 0.91% of anticancer activity. Induction of apoptosis was most predominant in the underlying mechanism which was rationalized by externalization of phosphatidyl serine and membrane blebbing. These findings support the efficiency of phytogenic fabrication of nanoscale platinum and palladium drugs for management and therapy against breast cancer.
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Academic Editor: Konstantinos Tsipis
ISSN:1565-3633
1687-479X
DOI:10.1155/2018/4924186