Search Results - "Duax, William L."

Dynamics of loops at the substrate entry channel determine the specificity of iridoid synthases by Sandholu, Anand S., Mohole, Madhura, Duax, William L., Thulasiram, Hirekodathakallu V., Sengupta, Durba, Kulkarni, Kiran

“…Iridoid synthases belong to the family of short‐chain dehydrogenase/reductase involved in the biosynthesis of iridoids. Despite having high sequence and…”
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Structure of uncomplexed and linoleate-bound Candida cylindracea cholesterol esterase by Ghosh, Debashis, Wawrzak, Zdzislaw, Pletnev, Vladimir Z, Li, Naiyin, Kaiser, Rudolf, Pangborn, Walter, Jörnvall, Hans, Erman, Mary, Duax, William L

“…Background: Candida cylindracea cholesterol esterase (CE) reversibly hydrolyzes cholesteryl linoleate and oleate. CE belongs to the same α/ β hydrolase…”
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The short‐chain oxidoreductase Q9HYA2 from Pseudomonas aeruginosa PAO1 contains an atypical catalytic center by Huether, Robert, Mao, Qilong, Duax, William L., Umland, Timothy C.

“…The characteristic oxidation or reduction reaction mechanisms of short‐chain oxidoreductase (SCOR) enzymes involve a highly conserved Asp‐Ser‐Tyr‐Lys catalytic…”
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Evolution of bacterial ribosomal protein L1 by Duax, William L, Huether, Robert, Dziak, David

“…Search vectors composed of Gly, Ala, Arg, and Pro (GARP) residues retrieve 98% of each of the ribosomal proteins in prokaryotic species with no false hits…”
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Did tRNA Synthetase Classes Arise on Opposite Strands of the Same Gene? by Carter, Charles W., Duax, William L.

“…Structural homology of class II aminoacyl-tRNA synthetases to the HSP70 family and the existence of a gene whose sense and antisense strands code for a…”
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Structure/Function Relationships Responsible for Coenzyme Specificity and the Isomerase Activity of Human Type 1 3β-Hydroxysteroid Dehydrogenase/Isomerase by Thomas, James L., Duax, William L., Addlagatta, Anthony, Brandt, Stacey, Fuller, Robert R., Norris, Wendy

“…Human type 1 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD/isomerase) catalyzes the two sequential enzyme reactions on a single protein that converts…”
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Rational proteomics I. Fingerprint identification and cofactor specificity in the short-chain oxidoreductase (SCOR) enzyme family by Duax, William L., Pletnev, Vladimir, Addlagatta, Anthony, Bruenn, Jeremy, Weeks, Charles M.

“…The short‐chain oxidoreductase (SCOR) family of enzymes includes over 2000 members identified in sequenced genomes. Of these enzymes, ∼200 have been…”
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Sequence fingerprint and structural analysis of the SCOR enzyme A3DFK9 from Clostridium thermocellum by Huether, Robert, Liu, Zhi-Jie, Xu, Hao, Wang, Bi-Cheng, Pletnev, Vladimir Z., Mao, Qilong, Duax, William L., Umland, Timothy C.

“…We have identified a highly conserved fingerprint of 40 residues in the TGYK subfamily of the short‐chain oxidoreductase enzymes. The TGYK subfamily is defined…”
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Structure/function of human type 1 3β-hydroxysteroid dehydrogenase: An intrasubunit disulfide bond in the Rossmann-fold domain and a Cys residue in the active site are critical for substrate and coenzyme utilization by Thomas, James L., Huether, Robert, Mack, Vance L., Scaccia, Launa A., Stoner, Ryan C., Duax, William L.

“…The human type 1 (placenta, breast tumors) and type 2 (gonads, adrenals) isoforms of 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD) are key enzymes in…”
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Determining Structure and Function of Steroid Dehydrogenase Enzymes by Sequence Analysis, Homology Modeling, and Rational Mutational Analysis by DUAX, WILLIAM L., THOMAS, JAMES, PLETNEV, VLADIMIR, ADDLAGATTA, ANTHONY, HUETHER, ROBERT, HABEGGER, LUKAS, WEEKS, CHARLES M.

“…: The short‐chain oxidoreductase (SCOR) family of enzymes includes over 6,000 members identified in sequenced genomes. Of these enzymes, ∼300 have been…”
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Structure of human estrogenic 17β-hydroxysteroid dehydrogenase at 2.20 å resolution by Ghosh, Debashis, Pletnev, Vladimir Z, Zhu, Dao-Wei, Wawrzak, Zdislaw, Duax, William L, Pangborn, Walter, Labrie, Fernand, Lin, Sheng-Xiang

“…Background: The principal human estrogen, 17 β-estradiol, is a potent stimulator of certain endocrine-dependent forms of breast cancer. Because human…”
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Rational genomics I: Antisense open reading frames and codon bias in short-chain oxido reductase enzymes and the evolution of the genetic code by Duax, William L., Huether, Robert, Pletnev, Vladimir Z., Langs, David, Addlagatta, Anthony, Connare, Sonjay, Habegger, Lukas, Gill, Jay

“…The short‐chain oxidoreductase (SCOR) family of enzymes includes over 6000 members, extending from bacteria and archaea to humans. Nucleic acid sequence…”
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Rational proteomics II: Electrostatic nature of cofactor preference in the short-chain oxidoreductase (SCOR) enzyme family by Pletnev, Vladimir Z., Weeks, Charles M., Duax, William L.

“…The dominant role of long‐range electrostatic interatomic interactions in nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate…”
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Determination of the crystal structure of EntA, a 2,3-dihydro-2,3-dihydroxybenzoic acid dehydrogenase from Escherichia coli by Sundlov, Jesse A., Garringer, Julie A., Carney, Jill M., Reger, Albert S., Drake, Eric J., Duax, William L., Gulick, Andrew M.

“…The Escherichia coli enterobactin synthetic cluster is composed of six proteins, EntA–EntF, that form the enterobactin molecule from three serine molecules and…”
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Rational proteomics V: Structure-based mutagenesis has revealed key residues responsible for substrate recognition and catalysis by the dehydrogenase and isomerase activities in human 3β-hydroxysteroid dehydrogenase/isomerase type 1 by Pletnev, Vladimir Z., Thomas, James L., Rhaney, Felicia L., Holt, Lynley S., Scaccia, Launa A., Umland, Timothy C., Duax, William L.

“…Mammalian 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD) is a member of the short chain dehydrogenase/reductase. It is a key steroidogenic enzyme that…”
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Solid-state conformation of anti-human immunodeficiency virus type-1 agents: Crystal structures of three 3'-azido-3'-deoxythymidine analogs by Van Roey, Patrick, Salerno, Jeffrey M, Duax, William L, Chu, Chung K, Ahn, Moon K, Schinazi, Raymond F

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Synthesis, Structure Elucidation, and Biochemical Evaluation of 7.alpha.- and 7.beta.-Arylaliphatic-Substituted Androst-4-ene-3,17-diones as Inhibitors of Aromatase by O'Reilly, Jill M, Li, Naiyin, Duax, William L, Brueggemeier, Robert W

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Divergent evolution of a Rossmann fold and identification of its oldest surviving ancestor by Duax, William L, Huether, Robert, Pletnev, Vladimir, Umland, Timothy C

“…beta-ketoacyl (acyl carrier protein) reductase (beta-k-ACPR) enzymes are essential to fatty acid synthesis in bacteria. The analyses revealed the most…”
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Structure/function aspects of human 3β-hydroxysteroid dehydrogenase by Thomas, James L, Duax, William L, Addlagatta, Anthony, Kacsoh, Balint, Brandt, Stacey E, Norris, Wendy B

“…Separate genes encode the human type 1 (placenta, breast tumors, other peripheral tissues) and type 2 (gonad, adrenal) isoforms of 3β-hydroxysteroid…”
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Gramicidin D conformation, dynamics and membrane ion transport by Burkhart, Brian M., Gassman, Ryan M., Langs, David A., Pangborn, Walter A., Duax, William L., Pletnev, Vladimir

“…The linear pentadecapeptide antibiotic, gramicidin D, a heterogeneous mixture of six components, is a naturally occurring product of Bacillus brevis known to…”
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