Search Results - "Duarte, Pilar"

Design, Selection, and Characterization of Thioflavin-Based Intercalation Compounds with Metal Chelating Properties for Application in Alzheimer’s Disease by Rodríguez-Rodríguez, Cristina, Sánchez de Groot, Natalia, Rimola, Albert, Álvarez-Larena, Ángel, Lloveras, Vega, Vidal-Gancedo, José, Ventura, Salvador, Vendrell, Josep, Sodupe, Mariona, González-Duarte, Pilar

“…Metal chelation is considered a rational therapeutic approach for interdicting Alzheimer’s amyloid pathogenesis. At present, enhancing the targeting and…”
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Crystal structure of thioflavin-T and its binding to amyloid fibrils: insights at the molecular level by Rodríguez-Rodríguez, Cristina, Rimola, Albert, Rodríguez-Santiago, Luis, Ugliengo, Piero, Alvarez-Larena, Angel, Gutiérrez-de-Terán, Hugo, Sodupe, Mariona, González-Duarte, Pilar

“…Combining X-ray data on thioflavin-T and theoretical calculations on its binding to a peptide model for Abeta(1-42) fibrils gives evidence of main stabilizing…”
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metal-binding properties of the blue crab copper specific CuMT-2: a crustacean metallothionein with two cysteine triplets by Serra-Batiste, Montserrat, Cols, Neus, Alcaraz, Luis A, Donaire, Antonio, González-Duarte, Pilar, Vašák, Milan

“…Most crustacean metallothioneins (MTs) contain 18 Cys residues and bind six divalent metal ions. The copper-specific CuMT-2 (MTC) of the blue crab Callinectes…”
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The comparison of mouse full metallothionein-1 versus α and β domains and metallothionein-1-to-3 mutation following traumatic brain injury reveals different biological motifs by Manso, Yasmina, Serra, Montserrat, Comes, Gemma, Giralt, Mercedes, Carrasco, Javier, Cols, Neus, Vašák, Milan, González-Duarte, Pilar, Hidalgo, Juan

“…Traumatic injury to the brain is one of the leading causes of injury‐related death or disability, but current therapies are limited. Previously it has been…”
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Reaction Chemistry of Complexes Containing PtH, PtSH, or PtS Fragments: From Their Apparent Simplicity to the Maze of Reactions Underlying Their Interconversion by Novio, Fernando, González-Duarte, Pilar, Lledós, Agustí, Mas-Ballesté, Rubén

“…The relevance of platinum in the reaction of thiophene and derivatives with homogeneous transition‐metal complexes as models for hydrodesulfurization has led…”
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In silico strategies for the selection of chelating compounds with potential application in metal-promoted neurodegenerative diseases by Rodríguez-Rodríguez, Cristina, Rimola, Albert, Alí-Torres, Jorge, Sodupe, Mariona, González-Duarte, Pilar

“…The development of new strategies to find commercial molecules with promising biochemical features is a main target in the field of biomedicine chemistry. In…”
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C-S Bond Activation and Partial Hydrogenation of Thiophene by a Dinuclear Trihydride Platinum Complex by Nova, Ainara, Novio, Fernando, González-Duarte, Pilar, Lledós, Agustí, Mas-Ballesté, Rubén

“…[(dppp)2Pt2H3]ClO4 [I, dppp = Ph2P(CH2)3PPh2] was found to activate the C–S bond and to cause partial hydrogenation of thiophene. Thus, the reaction of I with…”
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Extending The Reaction Landscape of the {Pt(μ-S)2Pt} Core: From Metal Centers to Non-Metallic Electrophiles by González-Duarte, Pilar, Lledós, Agustí, Mas-Ballesté, Rubén

“…The outstanding nucleophilicity of the {Pt(μ‐S)2Pt} core in compounds [L2Pt(μ‐S)2PtL2] (L2 = phosphane) accounts for their ability to act as metalloligands…”
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The Evolution of [{Ph2P(CH2)nPPh2}Pt(μ-S)2Pt{Ph2P(CH2)nPPh2}] (n=2, 3) Metalloligands in Protic Acids: A Cascade of Sequential Reactions by Mas-Ballesté, Rubén, Aullón, Gabriel, Champkin, Paul A., Clegg, William, Mégret, Claire, González-Duarte, Pilar, Lledós, Agustí

“…Given the nucleophilicity of the {Pt2S2} ring, the evolution of [Pt2(μ‐S)2(P∩P)2] (P∩P=1,2‐bis(diphenylphosphino)ethane (dppe),…”
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Cover Picture: Reaction Chemistry of Complexes Containing PtH, PtSH, or PtS Fragments: From Their Apparent Simplicity to the Maze of Reactions Underlying Their Interconversion (Chem. Eur. J. 4/2007) by Novio, Fernando, González-Duarte, Pilar, Lledós, Agustí, Mas-Ballesté, Rubén

“…A labyrinth mimicking the reaction pathways that govern the interconversion of complexes containing PtH, PtSH, and PtS fragments is depicted on the cover…”
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First Evidence of Fast SH⋅⋅⋅S Proton Transfer in a Transition Metal Complex by Aullón, Gabriel, Capdevila, Mercè, Clegg, William, González-Duarte, Pilar, Lledós, Agustí, Mas-Ballesté, Rubén

“…Despite the weakness of SH⋅⋅⋅S interactions and the fact that they have rarely been reported in transition‐metal compounds, variable‐temperature NMR data and…”
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Monitoring of the metal displacement from the recombinant mouse liver metallothionein Zn7-complex by capillary zone electrophoresis with electrospray MS detection by PAWLAK, Kasia Połec, PALACIOS, Oscar, CAPDEVILA, Mercè, GONZALEZ-DUARTE, Pilar, ŁOBINSKI, Ryszard

“…A solution of a Zn-complex of recombinant mouse MT-1 isoform (Zn7-MT-1) was prepared and titrated with Cd2+ ions. A method based on the coupling of capillary…”
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Aliphatic C–X (X = halogen) bond activation by transition metal complexes containing the {Pt 2S 2} core: A theoretical study of the reaction mechanism by Nova, Ainara, González-Duarte, Pilar, Lledós, Agustı́, Mas-Ballesté, Ruben, Ujaque, Gregori

“…[L 2Pt(μ-S) 2PtL 2] (L = phosphane) complexes have been found to cleave C–X bonds provided a significant excess of the corresponding alkyl halide is present in…”
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Mercury(II) binding to metallothioneins. Variables governing the formation and structural features of the mammalian Hg-MT species by Leiva-Presa, Angels, Capdevila, Mercè, Gonzàlez-Duarte, Pilar

“…With the aim of extending our knowledge on the reaction pathways of Zn-metallothionein (MT) and apo-MT species in the presence of Hg(II), we monitored the…”
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Extending The Reaction Landscape of the {Pt(μ-S)2Pt} Core: From Metal Centers to Non-Metallic Electrophiles by González-Duarte, Pilar, Lledós, Agustí, Mas-Ballesté, Rubén

“…See original Eur. J. Inorg. Chem. 2004, 3585–3599(DOI: 10.1002/ejic.200400422) …”
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Cover Picture: Extending The Reaction Landscape of the {Pt(μ-S)2Pt} Core: From Metal Centers to Non-Metallic Electrophiles (Eur. J. Inorg. Chem. 18/2004) by González-Duarte, Pilar, Lledós, Agustí, Mas-Ballesté, Rubén

“…The cover picture shows a butterfly mimicking the main features of compounds [L2Pt(ν‐S)2PtL2] (L2 = phosphane). Its flight simulates the flexibility of the…”
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Unusual C−H Allylic Activation in the {PtII(cod)} Fragment Bonded to a {Pt2(μ-S)2} Core by Mas-Ballesté, Rubén, Champkin, Paul A, Clegg, William, González-Duarte, Pilar, Lledós, Agustí, Ujaque, Gregori

“…Complexes [{Pt2(μ3-S)2(dppp)2}Pt(cod)]Cl2 (1) and [{Pt2(μ3-S)2(cod)2}Pt(dppp)]Cl2 (3), where dppp = 1,3-bis(diphenylphosphino)propane and cod =…”
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In vivo copper- and cadmium-binding ability of mammalian metallothionein β domain by Cols, Neus, Romero-Isart, Núria, Bofill, Roger, Capdevila, Mercè, Gonzàlez-Duarte, Pilar, Gonzàlez-Duarte, Roser, Atrian, Sílvia

“…The β domain of mouse metallothionein 1 (βMT) was synthesized in Escherichia coli cells grown in the presence of copper or cadmium. Homogenous preparations of…”
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Chemical foundation of the attenuation of methylmercury(II) cytotoxicity by metallothioneins by Leiva‐Presa, Àngels, Capdevila, Mercè, Cols, Neus, Atrian, Silvia, González‐Duarte, Pilar

“…To elucidate the chemical interactions underlying the role of metallothioneins (MTs) in reducing the cytotoxicity caused by MeHg(II), we monitored in parallel…”
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Synthesis and x-ray structure of zinc(II) derivatives of esters of 2-pyridinecarboxylic acid by González-Duarte, Pilar, March, Ricard, Pons, Josefina, Clegg, William, Cucurull-Sànchez, Lourdes, Álvarez-Larena, Angel, Piniella, Joan Francesc

“…Zinc(II) halides form a series of of 1:1 and 1:2 compexes with neutral 2-pyridinecarboxylate esters, which act as bidentate nitrogenoxygen donors, via…”
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