Search Results - "Duarte, Christine W"

Communication of Scientific Uncertainty about a Novel Pandemic Health Threat: Ambiguity Aversion and Its Mechanisms by Han, Paul K.J., Zikmund-Fisher, Brian J., Duarte, Christine W., Knaus, Megan, Black, Adam, Scherer, Aaron M., Fagerlin, Angela

“…Communicating scientific uncertainty about public health threats is ethically desirable but challenging due to its tendency to promote avoidance of choice…”
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Beyond missing heritability: prediction of complex traits by Makowsky, Robert, Pajewski, Nicholas M, Klimentidis, Yann C, Vazquez, Ana I, Duarte, Christine W, Allison, David B, de los Campos, Gustavo

“…Despite rapid advances in genomic technology, our ability to account for phenotypic variation using genetic information remains limited for many traits. This…”
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A prospective evaluation of the candle wax sign: A visual clue to diagnose aggressive basal cell carcinoma by O'Donnell, Brian Patrick, MD, MAT, Duarte, Christine W., PhD

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High Throughput Kinomic Profiling of Human Clear Cell Renal Cell Carcinoma Identifies Kinase Activity Dependent Molecular Subtypes by Anderson, Joshua C, Willey, Christopher D, Mehta, Amitkumar, Welaya, Karim, Chen, Dongquan, Duarte, Christine W, Ghatalia, Pooja, Arafat, Waleed, Madan, Ankit, Sudarshan, Sunil, Naik, Gurudatta, Grizzle, William E, Choueiri, Toni K, Sonpavde, Guru

“…Despite the widespread use of kinase-targeted agents in clear cell renal cell carcinoma (CC-RCC), comprehensive kinase activity evaluation (kinomic profiling)…”
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Expression signature of IFN/STAT1 signaling genes predicts poor survival outcome in glioblastoma multiforme in a subtype-specific manner by Duarte, Christine W, Willey, Christopher D, Zhi, Degui, Cui, Xiangqin, Harris, Jacqueline J, Vaughan, Laura Kelly, Mehta, Tapan, McCubrey, Raymond O, Khodarev, Nikolai N, Weichselbaum, Ralph R, Gillespie, G Yancey

“…Previous reports have implicated an induction of genes in IFN/STAT1 (Interferon/STAT1) signaling in radiation resistant and prosurvival tumor phenotypes in a…”
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Kinomic exploration of temozolomide and radiation resistance in Glioblastoma multiforme xenolines by Anderson, Joshua C, Duarte, Christine W, Welaya, Karim, Rohrbach, Timothy D, Bredel, Markus, Yang, Eddy S, Choradia, Nirmal V, Thottassery, Jaideep V, Yancey Gillespie, George, Bonner, James A, Willey, Christopher D

“…Abstract Background and purpose Glioblastoma multiforme (GBM) represents the most common and deadly primary brain malignancy, particularly due to temozolomide…”
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Elevated plasma levels of the pituitary hormone Cthrc1 in individuals with red hair but not in patients with solid tumors by Duarte, Christine W, Stohn, J Patrizia, Wang, Qiaozeng, Emery, Ivette F, Prueser, Andrew, Lindner, Volkhard

“…An increasing number of studies report that Cthrc1 is expressed in various cancer cells. The present study sought to identify which cells in tumors and…”
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Validation of the Patient-Reported Outcome Mortality Prediction Tool (PROMPT) by Duarte, Christine W., PhD, Black, Adam W, Murray, Kimberly, Haskins, Amy E, Lucas, Lee, Hallen, Sarah, Han, Paul K.J., MD, MA, MPH

“…Abstract Context The Patient-Reported Outcome Mortality Prediction Tool (PROMPT) estimates six-month mortality risk in elderly patients with declining health,…”
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Thyroid hormone influences brain gene expression programs and behaviors in later generations by altering germ line epigenetic information by Martinez, M. Elena, Duarte, Christine W., Stohn, J. Patrizia, Karaczyn, Aldona, Wu, Zhaofei, DeMambro, Victoria E, Hernandez, Arturo

“…Genetic factors do not fully account for the relatively high heritability of neurodevelopmental conditions, suggesting that non-genetic heritable factors…”
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High-dimensional pharmacogenetic prediction of a continuous trait using machine learning techniques with application to warfarin dose prediction in African Americans by COSGUN, Erdal, LIMDI, Nita A, DUARTE, Christine W

“…With complex traits and diseases having potential genetic contributions of thousands of genetic factors, and with current genotyping arrays consisting of…”
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Characterization of smooth muscle cells from human atherosclerotic lesions and their responses to Notch signaling by Davis-Knowlton, Jessica, Turner, Jacqueline E., Turner, Anna, Damian-Loring, Sydney, Hagler, Nicholas, Henderson, Terry, Emery, Ivette F., Bond, Kyle, Duarte, Christine W., Vary, Calvin P.H., Eldrup-Jorgensen, Jens, Liaw, Lucy

“…Atherosclerosis is the most common cause of heart disease and stroke. The use of animal models has advanced our understanding of the molecular signaling that…”
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Thyroid hormone overexposure decreases DNA methylation in germ cells of newborn male mice by Martinez, M. Elena, Duarte, Christine W., Stohn, J. Patrizia, Karaczyn, Aldona, Wu, Zhaofei, DeMambro, Victoria E., Hernandez, Arturo

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Derivation and Validation of the CREST Model for Very Early Prediction of Circulatory Etiology Death in Patients Without ST-Segment-Elevation Myocardial Infarction After Cardiac Arrest by Bascom, Karen E, Dziodzio, John, Vasaiwala, Samip, Mooney, Michael, Patel, Nainesh, McPherson, John, McMullan, Paul, Unger, Barbara, Nielsen, Niklas, Friberg, Hans, Riker, Richard R, Kern, Karl B, Duarte, Christine W, Seder, David B

“…No practical tool quantitates the risk of circulatory-etiology death (CED) immediately after successful cardiopulmonary resuscitation in patients without…”
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Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression by Ferrarese, Roberto, Harsh, 4th, Griffith R, Yadav, Ajay K, Bug, Eva, Maticzka, Daniel, Reichardt, Wilfried, Dombrowski, Stephen M, Miller, Tyler E, Masilamani, Anie P, Dai, Fangping, Kim, Hyunsoo, Hadler, Michael, Scholtens, Denise M, Yu, Irene L Y, Beck, Jürgen, Srinivasasainagendra, Vinodh, Costa, Fabrizio, Baxan, Nicoleta, Pfeifer, Dietmar, von Elverfeldt, Dominik, Backofen, Rolf, Weyerbrock, Astrid, Duarte, Christine W, He, Xiaolin, Prinz, Marco, Chandler, James P, Vogel, Hannes, Chakravarti, Arnab, Rich, Jeremy N, Carro, Maria S, Bredel, Markus

“…Tissue-specific alternative splicing is critical for the emergence of tissue identity during development, yet the role of this process in malignant…”
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miR-199b, a novel tumor suppressor miRNA in acute myeloid leukemia with prognostic implications by Favreau, Amanda J, McGlauflin, Rose E, Duarte, Christine W, Sathyanarayana, Pradeep

“…Dysregulation of miRNAs that can act as tumor suppressors or oncogenes can result in tumorigenesis. Previously we demonstrated that miR-199b was significantly…”
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Combinatorial Drug Testing in 3D Microtumors Derived from GBM Patient-Derived Xenografts Reveals Cytotoxic Synergy in Pharmacokinomics-informed Pathway Interactions by Gilbert, Ashley N., Anderson, Joshua C., Duarte, Christine W., Shevin, Rachael S., Langford, Catherine P., Singh, Raj, Gillespie, G. Yancey, Willey, Christopher D.

“…Glioblastoma multiforme (GBM), the most common form of primary malignant brain cancer in adults, is a devastating disease for which effective treatment has…”
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Improved Survival Outcomes in Cancer Patients with Hereditary Hemorrhagic Telangiectasia by DUARTE, Christine W, MURRAY, Kimberly, LUCAS, F. Lee, FAIRFIELD, Kathleen, MILLER, Heather, BROOKS, Peter, VARY, Calvin P. H

“…Hereditary hemorrhagic telangiectasia (HHT) is a genetic disorder characterized by deficiency in endoglin, an angiogenic protein. The net effect of endoglin…”
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Effects of vitamin A deficiency in the postnatal mouse heart: role of hepatic retinoid stores by Asson-Batres, Mary Ann, Ryzhov, Sergey, Tikhomirov, Oleg, Duarte, Christine W, Congdon, Clare Bates, Lessard, Craig R, McFarland, Samuel, Rochette-Egly, Cecile, Tran, Truc-Linh, Galindo, Cristi L, Favreau-Lessard, Amanda J, Sawyer, Douglas B

“…To determine whether hepatic depletion of vitamin A (VA) stores has an effect on the postnatal heart, studies were carried out with mice lacking liver retinyl…”
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MARCKS Regulates Growth and Radiation Sensitivity and Is a Novel Prognostic Factor for Glioma by JARBOE, John S, ANDERSON, Joshua C, BURLESON, Tamara M, BONNER, James A, YANCEY GILLESPIE, G, YANG, Eddy S, WILLEY, Christopher D, DUARTE, Christine W, MEHTA, Tapan, NOWSHEEN, Somaira, HICKS, Patricia H, WHITLEY, Alexander C, ROHRBACH, Timothy D, MCCUBREY, Raymond O, CHIU, Sherard

“…This study assessed whether myristoylated alanine-rich C-kinase substrate (MARCKS) can regulate glioblastoma multiforme (GBM) growth, radiation sensitivity,…”
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Complications of long and intermediate term venous catheters in cystic fibrosis patients: A multicenter study by May, Teresa L, Gifford, Alex H, Lahiri, Thomas, Black, Adam, Trang, Janet, Cornell, Alexandra G, Gonzalez, Karyll, Morin, Scott, Napier, Mark, Duarte, Christine W, Zuckerman, Jonathan B

“…Abstract Background Totally implantable venous access devices (TIVADs) or peripherally inserted central venous catheters (PICCs) are commonly used in the care…”
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