Efficacy and safety of mind-body exercise for patients with axial spondyloarthritis: a systematic review and meta-analysis

To evaluate the efficacy and safety of mind-body exercise (MBE) interventions, including Tai Chi, Yoga, Pilates, and Qigong, in patients with axial spondyloarthritis (axSpA), a systematic review and meta-analysis was conducted. Eight electronic databases were searched from their inception to May 202...

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Bibliographic Details
Published in:	Journal of orthopaedic surgery and research Vol. 19; no. 1; pp. 586 - 15
Main Authors:	Wang, Jing, Li, Xinmin, Yang, Fangjie, Guo, Pengxue, Ren, Chunlin, Duan, Zhengfei, Zhang, Yasu
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 28-09-2024 BioMed Central BMC
Subjects:	Adult Ankylosing spondylitis Axial spondyloarthritis Axial Spondyloarthritis - therapy Care and treatment Exercise Exercise Therapy - methods Female Humans Male Middle Aged Mind body therapy Mind-body exercise Mind-Body Therapies - methods Pain Qigong - methods Quality of Life Systematic Review Treatment Outcome Axial spondyloarthritis Systematic review Exercise Mind-body exercise Mind body therapy Ankylosing spondylitis
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Summary:	To evaluate the efficacy and safety of mind-body exercise (MBE) interventions, including Tai Chi, Yoga, Pilates, and Qigong, in patients with axial spondyloarthritis (axSpA), a systematic review and meta-analysis was conducted. Eight electronic databases were searched from their inception to May 2024. RevMan 5.4 and Stata 16.0 software were used for statistical analysis. Outcome measures included Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Visual Analog Scale (VAS), Bath Ankylosing Spondylitis Metrology Index (BASMI), Ankylosing Spondylitis Quality of Life (ASQoL) Scale, and adverse events. The methodological quality of the included studies was evaluated using the Cochrane risk of bias (RoB) tool (2.0). The certainty of evidence for each outcome was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria. Of the 330 studies retrieved, 15 studies satisfied the criteria for meta-analysis. Compared with the controls, MBE interventions significantly improved physical function (measured by BASFI, MD = -0.76, 95% CI: -1.01 to -0.50, P < 0.00001), disease activity (measured by BASDAI, MD = -0.76, 95% CI: -0.94 to -0.57, P < 0.00001), pain intensity (measured by VAS, MD = -0.89, 95% CI: -1.21 to -0.57, P < 0.00001), spinal mobility (measured by BASMI, MD = -0.44, 95% CI: -0.70 to -0.19, P = 0.0006), and quality of life (measured by ASQoL, MD = -2.14, 95% CI: -3.54 to -0.75, P = 0.003). Subgroup analyses revealed that Tai Chi appeared to demonstrate a more pronounced effect on pain reduction when compared to Qigong (test for subgroup difference: P = 0.005). The quality of evidence for these outcomes was estimated as moderate to low. Additionally, no serious adverse events related to MBE were identified among the included studies. Overall, MBE may be a promising non-pharmacological treatment to improve physical function, disease activity, pain intensity, spinal mobility, and quality of life in patients with axSpA. To enhance the certainty of the evidence, additional rigorous studies are needed to verify these findings.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23
ISSN:	1749-799X 1749-799X
DOI:	10.1186/s13018-024-05072-5