Strain Characterization of Streptococcus suis Serotypes 28 and 31, Which Harbor the Resistance Genes optrA and ant(6)-Ia

Strain Characterization of Streptococcus suis Serotypes 28 and 31, Which Harbor the Resistance Genes optrA and ant(6)-Ia

causes disease in pigs and is implicated increasingly in human disease worldwide. Although most clinical cases are associated with serotype 2, infections by other serotypes have sometimes been reported. Here, we sequenced the genome of a multidrug-resistant serotype 28 (strain 11313) and a multidrug...

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Bibliographic Details
Published in:Pathogens (Basel) Vol. 10; no. 2; p. 213
Main Authors: Wang, Shujie, Zhang, Defu, Jiang, Chenggang, He, Haijuan, Cui, Chenchen, Duan, Weitong, Hu, Shouping, Wang, Jun, Cai, Xuehui
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 16-02-2021
MDPI
Subjects:
Aminoglycoside antibiotics
Aminoglycosides
Animal models
Antibiotic resistance
Antibiotics
Antibodies
Arthritis
Astrocytes
Brain research
Cell proliferation
characterization
Demyelination
Deoxyribonucleic acid
DNA
Drug resistance
Evolution & development
Farms
Ganglia
Genes
genome
Genomes
Glial cells
Hogs
Immunohistochemistry
Laboratory animals
Multidrug resistance
Phylogenetics
Serotypes
Software
Spinal cord
Streptococcus infections
Streptococcus suis
Streptococcus suis serotype 28
Streptococcus suis serotype 31
Swine
Thickening
Virulence
Beijing China
United States > US
China
Germany
genome
Streptococcus suis serotype 28
Streptococcus suis serotype 31
antibiotic resistance
characterization
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Summary:causes disease in pigs and is implicated increasingly in human disease worldwide. Although most clinical cases are associated with serotype 2, infections by other serotypes have sometimes been reported. Here, we sequenced the genome of a multidrug-resistant serotype 28 (strain 11313) and a multidrug-resistant serotype 31 (strain 11LB5). Strain 11313 was apathogenic in mouse infection models, whereas strain 11LB5 displayed ganglion demyelination, meningeal thickening, congestion, mononuclear cell infiltration, massive proliferation of cortical glial cells, and bacteria (>10 CFU/g) in the spinal cord and ganglia in mice. Furthermore, immunohistochemistry found that the heavily infiltrated glial cells were astrocytes. Strain 11313 harbored the resistance genes , , , , , and strain 11LB5 harbored the resistance genes , , , , . Mouse studies showed that strain 11LB5 exhibited a similar virulence to serotype 2 strain 700794, highlighting the need for surveillance of the other serotype isolates, in addition to serotype 2, in farms. This is the first report of the aminoglycoside resistance gene in from animals. This suggests that might serve as an antibiotic resistance reservoir, which spreads the resistance gene or to other streptococcal pathogens on farms.
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These authors contributed equally.
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens10020213