Chronic fatigue syndrome patients have alterations in their oral microbiome composition and function

Host-microbe interactions have been implicated in the pathogenesis of chronic fatigue syndrome (CFS), but whether the oral microbiome is altered in CFS patients is unknown. We explored alterations of the oral microbiome in Chinese Han CFS patients using 16S rRNA gene sequencing and alterations in th...

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Published in:	PloS one Vol. 13; no. 9; p. e0203503
Main Authors:	Wang, Taiwu, Yu, Lei, Xu, Cong, Pan, Keli, Mo, Minglu, Duan, Mingxiang, Zhang, Yao, Xiong, Hongyan
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 11-09-2018 Public Library of Science (PLoS)
Subjects:	Adult Amino acids Analysis Asian Continental Ancestry Group Bacteria Biology and Life Sciences Care and treatment China Chronic fatigue syndrome Composition Deoxyribonucleic acid Disease prevention Diversity indices DNA DNA sequencing Ecology and Environmental Sciences Energy metabolism Epidemiology Fatigue Fatigue Syndrome, Chronic - microbiology Functional analysis Functional analysis (Mathematics) Fusobacteria - classification Fusobacteria - genetics Gene amplification Gene sequencing Genetic aspects Health care Humans Infections Inflammatory bowel disease Medicine and Health Sciences Metabolism Metagenome Microbiomes Microbiota Microbiota (Symbiotic organisms) Microorganisms Mouth - microbiology Oral diseases Pancreatic cancer Pathogenesis Patients Preventive medicine Probiotics Relative abundance rRNA 16S Wang, Lei China
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Summary:	Host-microbe interactions have been implicated in the pathogenesis of chronic fatigue syndrome (CFS), but whether the oral microbiome is altered in CFS patients is unknown. We explored alterations of the oral microbiome in Chinese Han CFS patients using 16S rRNA gene sequencing and alterations in the functional potential of the oral microbiome using PICRUSt. We found that Shannon and Simpson diversity indices were not different in CFS patients compared to healthy controls, but the overall oral microbiome composition was different (MANOVA, p < 0.01). CFS patients had a higher relative abundance of Fusobacteria compared with healthy controls. Further, the genera Leptotrichia, Prevotella, and Fusobacterium were enriched and Haemophilus, Veillonella, and Porphyromonas were depleted in CFS patients compared to healthy controls. Functional analysis from inferred metagenomes showed that bacterial genera altered in CFS patients were primarily associated with amino acid and energy metabolism. Our findings demonstrate that the oral microbiome in CFS patients is different from healthy controls, and these differences lead to shifts in functional pathways with implications for CFS pathogenesis. These findings increase our understanding of the relationship between the oral microbiota and CFS, which will advance our understanding of CFS pathogenesis and may contribute to future improvements in treatment and diagnosis.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 Competing Interests: The authors have declared that no competing interests exist. These authors jointly directed the project.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0203503