Search Results - "Duan, Matt"

R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer by HOLLAND, Sacha J, PAN, Alison, JING ZHANG, PINGYU DING, APATIRA, Ayodele, CHUA, Joanne, BRANDT, Ralf, PINE, Polly, GOFF, Dane, SINGH, Rajinder, PAYAN, Donald G, HITOSHI, Yasumichi, FRANCI, Christian, YUANMING HU, CHANG, Betty, WEIQUN LI, DUAN, Matt, TORNEROS, Allan, JIAXIN YU, HECKRODT, Thilo J

“…Accumulating evidence suggests important roles for the receptor tyrosine kinase Axl in cancer progression, invasion, metastasis, drug resistance, and patient…”
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Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality by Kulminski, Alexander M, He, Liang, Culminskaya, Irina, Loika, Yury, Kernogitski, Yelena, Arbeev, Konstantin G, Loiko, Elena, Arbeeva, Liubov, Bagley, Olivia, Duan, Matt, Yashkin, Arseniy, Fang, Fang, Kovtun, Mikhail, Ukraintseva, Svetlana V, Wu, Deqing, Yashin, Anatoliy I

“…Gaining insights into genetic predisposition to age-related diseases and lifespan is a challenging task complicated by the elusive role of evolution in these…”
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Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases by He, Liang, Kernogitski, Yelena, Kulminskaya, Irina, Loika, Yury, Arbeev, Konstantin G, Loiko, Elena, Bagley, Olivia, Duan, Matt, Yashkin, Arseniy, Ukraintseva, Svetlana V, Kovtun, Mikhail, Yashin, Anatoliy I, Kulminski, Alexander M

“…Age-related diseases may result from shared biological mechanisms in intrinsic processes of aging. Genetic effects on age-related diseases are often modulated…”
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Interactions Between Genes From Aging Pathways May Influence Human Lifespan and Improve Animal to Human Translation by Ukraintseva, Svetlana, Duan, Matt, Arbeev, Konstantin, Wu, Deqing, Bagley, Olivia, Yashkin, Arseniy P, Gorbunova, Galina, Akushevich, Igor, Kulminski, Alexander, Yashin, Anatoliy

“…A major goal of aging research is identifying genetic targets that could be used to slow or reverse aging - changes in the body and extend limits of human…”
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Cyclodextrin solubilization of the antibacterial agents triclosan and triclocarban: Formation of aggregates and higher-order complexes by Duan, Matt S., Zhao, Nelson, Össurardóttir, Ína B., Thorsteinsson, Thorsteinn, Loftsson, Thorsteinn

“…It is well known that water-soluble cyclodextrins form inclusion complexes with many lipophilic water-insoluble drugs and that such complexation frequently…”
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Corrigendum: Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases by He, Liang, Kernogitski, Yelena, Kulminskaya, Irina, Loika, Yury, Arbeev, Konstantin G, Loiko, Elena, Bagley, Olivia, Duan, Matt, Yashkin, Arseniy, Ukraintseva, Svetlana V, Kovtun, Mikhail, Yashin, Anatoliy I, Kulminski, Alexander M

“…[This corrects the article on p. 179 in vol. 7, PMID: 27790247.]…”
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R723, a selective JAK2 inhibitor, effectively treats JAK2V617F-induced murine myeloproliferative neoplasm by Shide, Kotaro, Kameda, Takuro, Markovtsov, Vadim, Shimoda, Haruko K., Tonkin, Elizabeth, Fang, Shuling, Liu, Chian, Gelman, Marina, Lang, Wayne, Romero, Jason, McLaughlin, John, Bhamidipati, Somasekhar, Clough, Jeffrey, Low, Caroline, Reitsma, Andrea, Siu, Stacey, Pine, Polly, Park, Gary, Torneros, Allan, Duan, Matt, Singh, Rajinder, Payan, Donald G., Matsunaga, Takuya, Hitoshi, Yasumichi, Shimoda, Kazuya

“…The activating mutations in JAK2 (including JAK2V617F) that have been described in patients with myeloproliferative neoplasms (MPNs) are linked directly to MPN…”
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Cyclodextrin Solubilization of the Antibacterial Agents Triclosan and Triclocarban: Effect of Ionization and Polymers by Loftsson, Thorsteinn, Oessurardottir, Ina B, Thorsteinsson, Thorsteinn, Duan, Matt, Masson, Mar

“…The natural beta -cyclodextrin ( beta CD) and its complexes have limited solubility in aqueous solutions. This low aqueous solubility, as well as low aqueous…”
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Decline in biological resilience as key manifestation of aging: Potential mechanisms and role in health and longevity by Ukraintseva, Svetlana, Arbeev, Konstantin, Duan, Matt, Akushevich, Igor, Kulminski, Alexander, Stallard, Eric, Yashin, Anatoliy

“…•Decline in biological resilience (ability to recover) is a key manifestation of aging contributing to increase in vulnerability to death with age.•Aging can…”
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51240 R209, A Skin Penetrant IRAK1 and IRAK4 Inhibitor for Topical Indications by Shaw, Simon, Li, Hui, Chan, Meagan, Chen, Yan, Duan, Matt, Heckrodt, Thilo, Markovtsov, Vadim, Lamagna, Chrystelle, Taylor, Vanessa, Masuda, Esteban

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It takes two: APOE4 and air pollution synergistically affect hippocampal volume in women by Ukraintseva, Svetlana, Popov, Vladimir, Arbeev, Konstantin, Duan, Matt, Yashin, Anatoliy

“…Background The APOE e4 allele (APOE4) is the strongest genetic risk factor for Alzheimer's Disease (AD), and exposure to air pollution is emerging as a major…”
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MicroRNA in Alzheimer’s Disease: Results of interaction analysis by Yashin, Anatoliy I, Wu, Deqing, Arbeev, Konstantin, Bagley, Olivia, Duan, Matt, Ukraintseva, Svetlana

“…Background MiRNA are multifunctional molecules involved in regulating posttranscriptional expression of genes. Several studies showed that miR‐107 influences…”
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Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses by Yashin, Anatoliy I., Fang, Fang, Kovtun, Mikhail, Wu, Deqing, Duan, Matt, Arbeev, Konstantin, Akushevich, Igor, Kulminski, Alexander, Culminskaya, Irina, Zhbannikov, Ilya, Yashkin, Arseniy, Stallard, Eric, Ukraintseva, Svetlana

“…Despite evident success in clarifying many important features of Alzheimer's disease (AD) the efficient methods of its prevention and treatment are not yet…”
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Compromised immunity rather than specific microbe may increase vulnerability to Alzheimer’s disease, and vaccines with beneficial off‐target effects may support immunity and prevent AD by Ukraintseva, Svetlana, Yashkin, Arseniy Pavlovich, Akushevich, Igor, Arbeev, Konstantin, Duan, Matt, Tropsha, Alex, Stallard, Eric, Yashin, Anatoliy

“…Background Diverse pathogens (viral, bacterial, fungal) were linked to Alzheimer’s disease (AD) suggesting that compromised immunity may play role in AD…”
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Vaccination Against Pneumonia May Provide Genotype-Specific Protection Against Alzheimer's Disease by Ukraintseva, Svetlana, Duan, Matt, Simanek, Amanda M, Holmes, Rachel, Bagley, Olivia, Rajendrakumar, Aravind L, Yashkin, Arseniy P, Akushevich, Igor, Tropsha, Alexander, Whitson, Heather, Yashin, Anatoliy, Arbeev, Konstantin

“…Vaccine repurposing that considers individual genotype may aid personalized prevention of Alzheimer's disease (AD). In this retrospective cohort study, we used…”
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Interplay between stress-related genes may influence Alzheimer’s disease development: The results of genetic interaction analyses of human data by Yashin, Anatoliy I., Wu, Deqing, Arbeev, Konstantin, Bagley, Olivia, Akushevich, Igor, Duan, Matt, Yashkin, Arseniy, Ukraintseva, Svetlana

“…•Interactions between the GCN2/EIF2AK4 and APP genes were associated with AD in the analysis of human data.•Detection of these associations is a step forward…”
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Causal effects of cardiovascular risk factors on onset of major age-related diseases: A time-to-event Mendelian randomization study by He, Liang, Culminskaya, Irina, Loika, Yury, Arbeev, Konstantin G., Bagley, Olivia, Duan, Matt, Yashin, Anatoliy I., Kulminski, Alexander M.

“…Elucidating the causal effects of common intermediate risk factors on the onset of age-related diseases is indispensable for developing prevention and…”
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Repurposing of existing vaccines for personalized prevention of Alzheimer’s disease: Vaccination against pneumonia may reduce AD risk depending on genotype by Ukraintseva, Svetlana, Yashkin, Arseniy, Duan, Matt, Akushevich, Igor, Arbeev, Konstantin, Wu, Deqing, Stallard, Eric, Tropsha, Alex, Yashin, Anatoliy

“…Background Repurposing of existing vaccines could be a promising approach to Alzheimer’s disease (AD) prevention, exploiting potential heterologous effects of…”
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Repurposing of existing vaccines for personalized prevention of Alzheimer’s disease: Vaccination against pneumonia may reduce AD risk depending on genotype: Genetics/genetic factors of Alzheimer's disease by Ukraintseva, Svetlana, Yashkin, Arseniy, Duan, Matt, Akushevich, Igor, Arbeev, Konstantin, Wu, Deqing, Stallard, Eric, Tropsha, Alex, Yashin, Anatoliy

“…Abstract Background Repurposing of existing vaccines could be a promising approach to Alzheimer’s disease (AD) prevention, exploiting potential heterologous…”
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Strong impact of natural-selection-free heterogeneity in genetics of age-related phenotypes by Kulminski, Alexander M, Huang, Jian, Loika, Yury, Arbeev, Konstantin G, Bagley, Olivia, Yashkin, Arseniy, Duan, Matt, Culminskaya, Irina

“…A conceptual difficulty in genetics of age-related phenotypes that make individuals vulnerable to disease in post-reproductive life is genetic heterogeneity…”
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