Search Results - "Duan, Lauren"
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Dynamic Transcriptional Responses to Injury of Regenerative and Non-regenerative Cardiomyocytes Revealed by Single-Nucleus RNA Sequencing
Published in Developmental cell (06-04-2020)“…The adult mammalian heart is incapable of regeneration following injury. In contrast, the neonatal mouse heart can efficiently regenerate during the first week…”
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C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import
Published in eLife (02-03-2020)“…Disruption of nucleocytoplasmic transport is increasingly implicated in the pathogenesis of neurodegenerative diseases, including ALS caused by a…”
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devCellPy is a machine learning-enabled pipeline for automated annotation of complex multilayered single-cell transcriptomic data
Published in Nature communications (07-09-2022)“…A major informatic challenge in single cell RNA-sequencing analysis is the precise annotation of datasets where cells exhibit complex multilayered identities…”
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In vivo visualization and molecular targeting of the cardiac conduction system
Published in The Journal of clinical investigation (17-10-2022)“…Accidental injury to the cardiac conduction system (CCS), a network of specialized cells embedded within the heart and indistinguishable from the surrounding…”
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Artificial Intelligence-Based Co-Facilitator (AICF) for Detecting and Monitoring Group Cohesion Outcomes in Web-Based Cancer Support Groups: Single-Arm Trial Study
Published in JMIR cancer (22-07-2024)“…Commonly offered as supportive care, therapist-led online support groups (OSGs) are a cost-effective way to provide support to individuals affected by cancer…”
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Therapist Feedback and Implications on Adoption of an Artificial Intelligence-Based Co-Facilitator for Online Cancer Support Groups: Mixed Methods Single-Arm Usability Study
Published in JMIR cancer (09-06-2023)“…The recent onset of the COVID-19 pandemic and the social distancing requirement have created an increased demand for virtual support programs. Advances in…”
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Abstract Mo062: Cpne5 is Necessary for Normal Sinoatrial Node Function
Published in Circulation research (02-08-2024)“…Abstract only Background: Cpne5 (Copine 5) is a Ca2+-dependent phospholipid binding protein implicated in membrane trafficking but has no known role within the…”
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Abstract P3050: Cpne5 Is Necessary For Normal Murine Sinoatrial Node Function In Vivo
Published in Circulation research (04-08-2023)“…Abstract only Cpne5 ( Copine 5 ) is a Ca 2+ -dependent phospholipid binding protein implicated in membrane trafficking but has no known role within the heart…”
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Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export
Published in Cell reports (Cambridge) (19-07-2022)“…Nuclear clearance of the RNA-binding protein TDP-43 is a hallmark of neurodegeneration and an important therapeutic target. Our current understanding of TDP-43…”
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Cardiac Development at a Single-Cell Resolution
Published in Advances in experimental medicine and biology (2024)“…Mammalian cardiac development is a complex, multistage process. Though traditional lineage tracing studies have characterized the broad trajectories of cardiac…”
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Abstract P1001: IGFBP2 Overcomes Cell Contact-mediated Proliferation Inhibition In Human IPSC-derived Cardiomyocytes
Published in Circulation research (05-08-2022)“…Introduction and HypothesisHuman induced pluripotent stem cells (hiPSCs) and their derivatives provide a promising cellular source for regenerative cardiac…”
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Dynamic Transcriptional Responses to Injury of Regenerative and Non-regenerative Cardiomyocytes Revealed by Single-Nucleus RNA Sequencing
Published in Developmental cell (07-12-2020)Get full text
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