Search Results - "Duan, Chunwen"

Application of patient-derived induced pluripotent stem cells and organoids in inherited retinal diseases by Liang, Yuqin, Sun, Xihao, Duan, Chunwen, Tang, Shibo, Chen, Jiansu

“…Inherited retinal diseases (IRDs) can induce severe sight-threatening retinal degeneration and impose a considerable economic burden on patients and society,…”
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Introduction of an RS1 mutation causative variant consistent with identified XLRS patient using CRISPR/Cas9 technology in normal iPSC by Sun, Xihao, Mao, Shengru, Liang, Yuqin, Duan, Chunwen, Cui, Zekai, Gu, Jianing, Jiang, Bing, Ding, Chengcheng, Chen, Jiansu, Tang, Shibo

“…X-linked retinoschisis (XLRS) is a common retinal genetic disease that occurs in juvenile males and causes progressive visual impairment. This presents a…”
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Retinal organoids with X-linked retinoschisis RS1 (E72K) mutation exhibit a photoreceptor developmental delay and are rescued by gene augmentation therapy by Duan, Chunwen, Ding, Chengcheng, Sun, Xihao, Mao, Shengru, Liang, Yuqin, Liu, Xinyu, Ding, Xiaoyan, Chen, Jiansu, Tang, Shibo

“…X-linked juvenile retinoschisis (XLRS) is an inherited disease caused by RS1 gene mutation, which leads to retinal splitting and visual impairment. The…”
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Generation of a gene-corrected isogenic iPSC cell line from an X-linked retinoschisis patient with a hemizygous mutation c.304C > T (p.R102W) in RS1 gene by Mao, Shengru, Sun, Xihao, Duan, Chunwen, Jiang, Bing, Ma, Hongjie, Ji, Shangli, Liang, Yuqin, Zhang, Ruting, Chen, Jiansu, Tang, Shibo

“…X-linked retinoschisis (XLRS) is one of the most common retinal genetic diseases with progressive visual impairment in childhood affecting males. It is…”
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CRISPR/Cas9-mediated generation of a human induced pluripotent stem cell line with PRPF6 c.2699 G > A mutation to model retinitis pigmentosa by Liang, Yuqin, Sun, Xihao, Chen, Hang, Cui, Zekai, Gu, Jianing, Duan, Chunwen, Mao, Shengru, Chen, Yuexi, Li, Xiaoxue, Xiong, Siqi, Chen, Jiansu

“…PRPF6, located on chromosome 20, is required for the formation of the spliceosome. Mutations in the PRPF6 gene can lead to retinitis pigmentosa (RP), a common…”
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Establishment of a human induced pluripotent stem cell line (CSUASOi010-A) by reprogramming peripheral blood mononuclear cells of a type 2 diabetic mellitus patient by Ding, Chengcheng, Tan, Feng, Zhou, Yalan, Duan, Chunwen, Gu, Jianing, Cui, Zekai, Chen, Zhongping, Tang, Shibo, Chen, Jiansu

“…Type 2 diabetes mellitus (T2DM) is a major caused by insulin resistance with a relative deficiency in insulin secretion. Statistically, T2DM accounts for 90%…”
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Generation of a gene-corrected human iPSC line (CSUASOi004-A-1) from a retinitis pigmentosa patient with heterozygous c.2699 G>A mutation in the PRPF6 gene by Liang, Yuqin, Sun, Xihao, Duan, Chunwen, Zhou, Yalan, Cui, Zekai, Ding, Chengcheng, Gu, Jianing, Mao, Shengru, Ji, Shangli, Chan, Hon Fai, Tang, Shibo, Chen, Jiansu

“…Retinitis pigmentosa (RP) is one of the most common inherited retinal diseases characterized by nyctalopia, progressive vision loss and visual field…”
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One-stop assembly of adherent 3D retinal organoids from hiPSCs based on 3D-printed derived PDMS microwell platform by Sun, Xihao, Cui, Zekai, Liang, Yuqin, Duan, Chunwen, Chan, Hon Fai, Mao, Shengru, Gu, Jianing, Ding, Chengcheng, Yang, Xu, Wang, Qing, Tang, Shibo, Chen, Jiansu

“…The three-dimensional (3D) retinal organoids (ROs) derived from human induced pluripotent stem cells (hiPSCs), mimicking the growth and development of the…”
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Generation of a gene-corrected isogenic human iPSC line (CSUASOi006-A-1) from a retinitis pigmentosa patient with heterozygous c.5792C > T mutation in the PRPF8 gene by Sun, Xihao, Liang, Yuqin, Duan, Chunwen, Liu, Xujie, Zhou, Yalan, Mao, Shengru, Cui, Zekai, Gu, Jianing, Ding, Chengcheng, Chen, Jiansu, Tang, Shibo

“…Retinitis pigmentosa (RP) is a common inherited retinal disease characterized by progressive degeneration of the retina, leading to night blindness,…”
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Protective factors for diabetic retinopathy in Type 2 diabetes mellitus patients: Long duration of no less than 10 years by Liu, Yanli, Duan, Chunwen, Fang, Dejia, Liu, Yi, Xu, Hanchun, Zheng, Yarong, Xuan, Yaling, Wang, Lili, Ye, Lin, Su, Rui, An, Meixia

“…To study the factors protecting against diabetic retinopathy (DR) in patients with over a decade-long history of type 2 diabetes mellitus. A total of 490…”
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