Search Results - "DuFort, Christopher C"

Balancing forces: architectural control of mechanotransduction by Weaver, Valerie M, DuFort, Christopher C, Paszek, Matthew J

“…Key Points Cells have complex machinery capable of sensing and responding to mechanical cues from their microenvironment through a process termed…”
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Photostable Ratiometric Pdot Probe for in Vitro and in Vivo Imaging of Hypochlorous Acid by Wu, Li, Wu, I-Che, DuFort, Christopher C, Carlson, Markus A, Wu, Xu, Chen, Lei, Kuo, Chun-Ting, Qin, Yuling, Yu, Jiangbo, Hingorani, Sunil R, Chiu, Daniel T

“…Developing probes for the detection of reactive oxygen species (ROS), a hallmark of many pathophysiological process, is imperative to both understanding the…”
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Mesenchymal Lineage Heterogeneity Underlies Nonredundant Functions of Pancreatic Cancer-Associated Fibroblasts by Helms, Erin J, Berry, Mark W, Chaw, R Crystal, DuFort, Christopher C, Sun, Duanchen, Onate, M Kathrina, Oon, Chet, Bhattacharyya, Sohinee, Sanford-Crane, Hannah, Horton, Wesley, Finan, Jennifer M, Sattler, Ariana, Makar, Rosemary, Dawson, David W, Xia, Zheng, Hingorani, Sunil R, Sherman, Mara H

“…Cancer-associated fibroblast (CAF) heterogeneity is increasingly appreciated, but the origins and functions of distinct CAF subtypes remain poorly understood…”
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The cancer glycocalyx mechanically primes integrin-mediated growth and survival by Paszek, Matthew J., DuFort, Christopher C., Rossier, Olivier, Bainer, Russell, Mouw, Janna K., Godula, Kamil, Hudak, Jason E., Lakins, Jonathon N., Wijekoon, Amanda C., Cassereau, Luke, Rubashkin, Matthew G., Magbanua, Mark J., Thorn, Kurt S., Davidson, Michael W., Rugo, Hope S., Park, John W., Hammer, Daniel A., Giannone, Grégory, Bertozzi, Carolyn R., Weaver, Valerie M.

“…Malignancy is associated with altered expression of glycans and glycoproteins that contribute to the cellular glycocalyx. We constructed a glycoprotein…”
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Interstitial Pressure in Pancreatic Ductal Adenocarcinoma Is Dominated by a Gel-Fluid Phase by DuFort, Christopher C., DelGiorno, Kathleen E., Carlson, Markus A., Osgood, Ryan J., Zhao, Chunmei, Huang, Zhongdong, Thompson, Curtis B., Connor, Robert J., Thanos, Christopher D., Scott Brockenbrough, J., Provenzano, Paolo P., Frost, Gregory I., Michael Shepard, H., Hingorani, Sunil R.

“…Elevated interstitial fluid pressure can present a substantial barrier to drug delivery in solid tumors. This is particularly true of pancreatic ductal…”
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Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate by Rubashkin, Matthew G, Cassereau, Luke, Bainer, Russell, DuFort, Christopher C, Yui, Yoshihiro, Ou, Guanqing, Paszek, Matthew J, Davidson, Michael W, Chen, Yunn-Yi, Weaver, Valerie M

“…Extracellular matrix (ECM) stiffness induces focal adhesion assembly to drive malignant transformation and tumor metastasis. Nevertheless, how force alters…”
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Optical painting and fluorescence activated sorting of single adherent cells labelled with photoswitchable Pdots by Kuo, Chun-Ting, Thompson, Alison M., Gallina, Maria Elena, Ye, Fangmao, Johnson, Eleanor S., Sun, Wei, Zhao, Mengxia, Yu, Jiangbo, Wu, I-Che, Fujimoto, Bryant, DuFort, Christopher C., Carlson, Markus A., Hingorani, Sunil R., Paguirigan, Amy L., Radich, Jerald P., Chiu, Daniel T.

“…The efficient selection and isolation of individual cells of interest from a mixed population is desired in many biomedical and clinical applications. Here we…”
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Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension by Rys, Joanna P, DuFort, Christopher C, Monteiro, David A, Baird, Michelle A, Oses-Prieto, Juan A, Chand, Shreya, Burlingame, Alma L, Davidson, Michael W, Alliston, Tamara N

“…Cell surface receptors are central to the cell's ability to generate coordinated responses to the multitude of biochemical and physical cues in the…”
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Optical Field Enhancement at Cusps between Adjacent Nanoapertures by Onuta, Tiberiu-Dan, Waegele, Matthias, DuFort, Christopher C, Schaich, William L, Dragnea, Bogdan

“…Optical nonlinear properties of cusps formed at the junction between two circular apertures in a metal film have been studied by scanning confocal microscopy…”
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Mounting Pressure in the Microenvironment: Fluids, Solids, and Cells in Pancreatic Ductal Adenocarcinoma by DuFort, Christopher C, DelGiorno, Kathleen E, Hingorani, Sunil R

“…Abstract The microenvironment makes an important contribution to the pathogenesis of solid tumors and has an outsized role in some. Our understanding of the…”
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A BODIPY‐Based Donor/Donor–Acceptor System: Towards Highly Efficient Long‐Wavelength‐Excitable Near‐IR Polymer Dots with Narrow and Strong Absorption Features by Chen, Lei, Chen, Dandan, Jiang, Yifei, Zhang, Jicheng, Yu, Jiangbo, DuFort, Christopher C., Hingorani, Sunil R., Zhang, Xuanjun, Wu, Changfeng, Chiu, Daniel T.

“…Bright long‐wavelength‐excitable semiconducting polymer dots (LWE‐Pdots) are highly desirable for in vivo imaging and multiplexed in vitro bioassays. LWE‐Pdots…”
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Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix by Mekhdjian, Armen H, Kai, FuiBoon, Rubashkin, Matthew G, Prahl, Louis S, Przybyla, Laralynne M, McGregor, Alexandra L, Bell, Emily S, Barnes, J Matthew, DuFort, Christopher C, Ou, Guanqing, Chang, Alice C, Cassereau, Luke, Tan, Steven J, Pickup, Michael W, Lakins, Jonathan N, Ye, Xin, Davidson, Michael W, Lammerding, Jan, Odde, David J, Dunn, Alexander R, Weaver, Valerie M

“…Metastasis requires tumor cells to navigate through a stiff stroma and squeeze through confined microenvironments. Whether tumors exploit unique biophysical…”
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Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment by Derry, Jonathan M J, Burns, Connor, Frazier, Jason P, Beirne, Emily, Grenley, Marc, DuFort, Christopher C, Killingbeck, Emily, Leon, Michael, Williams, Claire, Gregory, Mark, Houlton, Jeffrey, Clayburgh, Daniel, Swiecicki, Paul, Huszar, Dennis, Berger, Allison, Klinghoffer, Richard A

“…Cancer drug development is currently limited by a paradigm of preclinical evaluation that does not adequately recapitulate the complexity of the intact human…”
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YAP forces fibroblasts to feel the tension by Maller, Ori, DuFort, Christopher C., Weaver, Valerie M.

“…Cancer-associated fibroblasts (CAFs) may contribute to tissue tension and cancer progression by increasing extracellular matrix (ECM) deposition and…”
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Cancer-associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth by Yuan, Meng, Tu, Bo, Li, Hengchao, Pang, Huanhuan, Zhang, Nan, Fan, Minghe, Bai, Jingru, Wang, Wei, Shu, Zhaoqi, DuFort, Christopher C, Huo, Sihan, Zhai, Jie, Yao, Ke, Wang, Lina, Ying, Haoqiang, Zhu, Wei-Guo, Fu, Deliang, Hu, Zeping, Zhao, Ying

“…Cancer-associated fibroblasts (CAFs) are one of the most prominent and active components in the pancreatic tumor microenvironment. Our data show that CAFs are…”
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Scanning angle interference microscopy reveals cell dynamics at the nanoscale by Paszek, Matthew J, DuFort, Christopher C, Rubashkin, Matthew G, Davidson, Michael W, Thorn, Kurt S, Liphardt, Jan T, Weaver, Valerie M

“…This paper reports a fluorescence imaging method based on interference contrast in which the incidence angle of the excitation light is actively scanned. The…”
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Tension and Transformation in Pancreas Cancer: Can Phenotype Break Free from the Chrysalis of Genotype? by DuFort, Christopher C., Hingorani, Sunil R.

“…A recent study finds that impaired TGFβ signaling can initiate a positive feedback loop between increasing ECM stiffness and epithelial cell contractility in…”
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Bio-enabled synthesis of metamaterials by DuFort, Christopher C, Dragnea, Bogdan

“…Biological systems offer more than an inspiration for the spontaneous hierarchical organization of matter at length scales between 1 and 1000 nm. They also…”
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Non-Invasive Monitoring of Stromal Biophysics with Targeted Depletion of Hyaluronan in Pancreatic Ductal Adenocarcinoma by Maloney, Ezekiel, DuFort, Christopher C, Provenzano, Paolo P, Farr, Navid, Carlson, Markus A, Vohra, Ravneet, Park, Joshua, Hingorani, Sunil R, Lee, Donghoon

“…Pancreatic ductal adenocarcinoma (PDA) is characterized by a pronounced fibroinflammatory stromal reaction consisting of inordinate levels of hyaluronan (HA),…”
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SMYD2 inhibition-mediated hypomethylation of Ku70 contributes to impaired nonhomologous end joining repair and antitumor immunity by Tang, Ming, Chen, Guofang, Tu, Bo, Hu, Zhiyi, Huang, Yujia, DuFort, Christopher C, Wan, Xiaoping, Mao, Zhiyong, Liu, Yongzhong, Zhu, Wei-Guo, Lu, Wen

“…DNA damage repair (DDR) is a double-edged sword with different roles in cancer susceptibility and drug resistance. Recent studies suggest that DDR inhibitors…”
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