Search Results - "Du, YunGuang"

UPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans by Shpilka, Tomer, Du, YunGuang, Yang, Qiyuan, Melber, Andrew, Uma Naresh, Nandhitha, Lavelle, Joshua, Kim, Sookyung, Liu, Pengpeng, Weidberg, Hilla, Li, Rui, Yu, Jun, Zhu, Lihua Julie, Strittmatter, Lara, Haynes, Cole M.

“…As organisms develop, individual cells generate mitochondria to fulfill physiological requirements. However, it remains unknown how mitochondrial network…”
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LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria by Yang, Qiyuan, Liu, Pengpeng, Anderson, Nadine S., Shpilka, Tomer, Du, YunGuang, Naresh, Nandhitha Uma, Li, Rui, Zhu, Lihua Julie, Luk, Kevin, Lavelle, Josh, Zeinert, Rilee D., Chien, Peter, Wolfe, Scot A., Haynes, Cole M.

“…The accumulation of deleterious mitochondrial DNA (∆mtDNA) causes inherited mitochondrial diseases and ageing-associated decline in mitochondrial functions…”
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BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers by Tang, Zhiyu, Yuan, Xi, Du, Rong, Cheung, Shing-Hu, Zhang, Guoliang, Wei, Jing, Zhao, Yuan, Feng, Yingcai, Peng, Hao, Zhang, Yi, Du, Yunguang, Hu, Xiaoxia, Gong, Wenfeng, Liu, Yong, Gao, Yajuan, Liu, Ye, Hao, Rui, Li, Shengjian, Wang, Shaohui, Ji, Jiafu, Zhang, Lianhai, Li, Shuangxi, Sutton, David, Wei, Min, Zhou, Changyou, Wang, Lai, Luo, Lusong

“…Oncogenic BRAF, which drives cell transformation and proliferation, has been detected in approximately 50% of human malignant melanomas and 5% to 15% of…”
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RAF dimer inhibition enhances the antitumor activity of MEK inhibitors in K‐RAS mutant tumors by Yuan, Xi, Tang, Zhiyu, Du, Rong, Yao, Zhan, Cheung, Shing‐Hu, Zhang, Xinwen, Wei, Jing, Zhao, Yuan, Du, Yunguang, Liu, Ye, Hu, Xiaoxia, Gong, Wenfeng, Liu, Yong, Gao, Yajuan, Huang, Zhiyue, Cao, Zongfu, Wei, Min, Zhou, Changyou, Wang, Lai, Rosen, Neal, Smith, Paul D., Luo, Lusong

“…The mutation of K‐RAS represents one of the most frequent genetic alterations in cancer. Targeting of downstream effectors of RAS, including of MEK and ERK,…”
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Mitochondrial inorganic polyphosphate is required to maintain proteostasis within the organelle by Da Costa, Renata T, Urquiza, Pedro, Perez, Matheus M, Du, YunGuang, Khong, Mei Li, Zheng, Haiyan, Guitart-Mampel, Mariona, Elustondo, Pia A, Scoma, Ernest R, Hambardikar, Vedangi, Ueberheide, Beatrix, Tanner, Julian A, Cohen, Alejandro, Pavlov, Evgeny V, Haynes, Cole M, Solesio, Maria E

“…The existing literature points towards the presence of robust mitochondrial mechanisms aimed at mitigating protein dyshomeostasis within the organelle…”
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Mitochondrial UPR repression during Pseudomonas aeruginosa infection requires the bZIP protein ZIP-3 by Deng, Pan, Naresh, Nandhitha Uma, Du, Yunguang, Lamech, Lilian T., Yu, Jun, Zhu, Lihua Julie, Pukkila-Worley, Read, Haynes, Cole M.

“…Mitochondria generate most cellular energy and are targeted by multiple pathogens during infection. In turn, metazoans employ surveillance mechanisms such as…”
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Mitochondrial genome recovery by ATFS-1 is essential for development after starvation by Uma Naresh, Nandhitha, Kim, Sookyung, Shpilka, Tomer, Yang, Qiyuan, Du, Yunguang, Haynes, Cole M.

“…Nutrient availability regulates the C. elegans life cycle as well as mitochondrial physiology. Food deprivation significantly reduces mitochondrial genome…”
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ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription by Dai, Chuan-Yang, Ng, Chai Chee, Hung, Grace Ching Ching, Kirmes, Ina, Hughes, Laetitia A., Du, Yunguang, Brosnan, Christopher A., Ahier, Arnaud, Hahn, Anne, Haynes, Cole M., Rackham, Oliver, Filipovska, Aleksandra, Zuryn, Steven

“…The ability to balance conflicting functional demands is critical for ensuring organismal survival. The transcription and repair of the mitochondrial genome…”
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Abstract 2589: Investigations of covalent binding efficiency for third-generation EGFR irreversible inhibitors AZD9291 and CO-1686 by Qin, Zhen, Sun, Xuebing, Liu, Ye, Du, Yunguang, Wang, Miao, Hu, Nan, Zhang, Jiye, Peng, Hao, Wang, Lai, Wei, Min, Luo, Lusong

“…Patients with non-small cell lung cancer with activating EGFR mutations initially respond to first-generation and second-generation EGFR inhibitors. However,…”
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Abstract 669: BGB-283 effectively enhances MEK inhibitor induced tumor suppression in RAS mutant cancers by Yuan, Xi, Tang, Zhiyu, Du, Rong, Cheung, Shing-Hu, Wei, Jing, Zhao, Yuan, Du, Yunguang, Hao, Rui, Hu, Xiaoxia, Gong, Wenfeng, Liu, Yong, Gao, Yajuan, Wei, Min, Zhou, Changyou, Wang, Lai, Luo, Lusong

“…Mutation in K-RAS, which drives constitutive activation of the mitogen-activated protein kinase (MAPK) signaling pathway, is one of the most frequent genetic…”
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UPR mt scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans by Shpilka, Tomer, Du, YunGuang, Yang, Qiyuan, Melber, Andrew, Uma Naresh, Nandhitha, Lavelle, Joshua, Kim, Sookyung, Liu, Pengpeng, Weidberg, Hilla, Li, Rui, Yu, Jun, Zhu, Lihua Julie, Strittmatter, Lara, Haynes, Cole M

“…As organisms develop, individual cells generate mitochondria to fulfill physiological requirements. However, it remains unknown how mitochondrial network…”
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Abstract 4692: BGB-283, a novel RAF kinase and EGFR dual inhibitor, displays potent antitumor activity in B-RAF mutated colorectal cancers by Tang, Zhiyu, Yuan, Xi, Du, Rong, Cheung, Shing-Hu, Zhang, Guoliang, Wei, Jing, Zhao, Yuan, Feng, Yingcai, Zhang, Yi, Du, Yunguang, Hu, Xiaoxia, Gong, Wenfeng, Liu, Yong, Gao, Yajuan, Hao, Rui, Ji, Jiafu, Zhang, Lianhai, Li, Shuangxi, Sutton, David, Wei, Min, Zhou, Changyou, Wang, Lai, Luo, Lusong

“…Oncogenic B-RAF, which drives cell transformation and proliferation, has been detected in approximately 70% of human malignant melanomas and 5-15% of…”
Get full text