Search Results - "Du, Siling"

Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels by Mazzitelli, Jose A., Smyth, Leon C. D., Cross, Kevin A., Dykstra, Taitea, Sun, Jerry, Du, Siling, Mamuladze, Tornike, Smirnov, Igor, Rustenhoven, Justin, Kipnis, Jonathan

“…It remains unclear how immune cells from skull bone marrow niches are recruited to the meninges. Here we report that cerebrospinal fluid (CSF) accesses skull…”
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Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice by Zhou, Tian, Li, Yuxin, Li, Xiaoyu, Zeng, Fanzhuo, Rao, Yanxia, He, Yang, Wang, Yafei, Liu, Meizhen, Li, Dali, Xu, Zhen, Zhou, Xin, Du, Siling, Niu, Fugui, Peng, Jiyun, Mei, Xifan, Ji, Sheng-Jian, Shu, Yousheng, Lu, Wei, Guo, Feifan, Wu, Tianzhun, Yuan, Ti-Fei, Mao, Ying, Peng, Bo

“…Microglia are important immune cells in the central nervous system (CNS) that undergo turnover throughout the lifespan. If microglial debris is not removed in…”
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TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways by Wang, Shoutang, Sudan, Raki, Peng, Vincent, Zhou, Yingyue, Du, Siling, Yuede, Carla M, Lei, Tingting, Hou, Jinchao, Cai, Zhangying, Cella, Marina, Nguyen, Khai, Poliani, Pietro L, Beatty, Wandy L, Chen, Yun, Cao, Siyan, Lin, Kent, Rodrigues, Cecilia, Ellebedy, Ali H, Gilfillan, Susan, Brown, Gordon D, Holtzman, David M, Brioschi, Simone, Colonna, Marco

“…Genetic studies have highlighted microglia as pivotal in orchestrating Alzheimer's disease (AD). Microglia that adhere to Aβ plaques acquire a transcriptional…”
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NeuroD1 induces microglial apoptosis and cannot induce microglia-to-neuron cross-lineage reprogramming by Rao, Yanxia, Du, Siling, Yang, Baozhi, Wang, Yuqing, Li, Yuxin, Li, Ruofan, Zhou, Tian, Du, Xiangjuan, He, Yang, Wang, Yafei, Zhou, Xin, Yuan, Ti-Fei, Mao, Ying, Peng, Bo

“…The regenerative capacity of neurons is limited in the central nervous system (CNS), with irreversible neuronal loss upon insult. In contrast, microglia…”
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Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage by Rustenhoven, Justin, Pavlou, Georgios, Storck, Steffen E, Dykstra, Taitea, Du, Siling, Wan, Zhengpeng, Quintero, Daniel, Scallan, Joshua P, Smirnov, Igor, Kamm, Roger D, Kipnis, Jonathan

“…The meningeal lymphatic network enables the drainage of cerebrospinal fluid (CSF) and facilitates the removal of central nervous system (CNS) waste. During…”
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Identification of direct connections between the dura and the brain by Smyth, Leon C. D., Xu, Di, Okar, Serhat V., Dykstra, Taitea, Rustenhoven, Justin, Papadopoulos, Zachary, Bhasiin, Kesshni, Kim, Min Woo, Drieu, Antoine, Mamuladze, Tornike, Blackburn, Susan, Gu, Xingxing, Gaitán, María I., Nair, Govind, Storck, Steffen E., Du, Siling, White, Michael A., Bayguinov, Peter, Smirnov, Igor, Dikranian, Krikor, Reich, Daniel S., Kipnis, Jonathan

“…The arachnoid barrier delineates the border between the central nervous system and dura mater. Although the arachnoid barrier creates a partition,…”
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Primary Microglia Isolation from Postnatal Mouse Brains by Du, Siling, Xiong, Shanshan, Du, Xiangjuan, Yuan, Ti-Fei, Peng, Bo, Rao, Yanxia

“…Microglia are the mononuclear phagocytes in the central nervous system (CNS), which play key roles in maintaining homeostasis and regulating the inflammatory…”
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Engineered T cell therapy for central nervous system injury by Gao, Wenqing, Kim, Min Woo, Dykstra, Taitea, Du, Siling, Boskovic, Pavle, Lichti, Cheryl F., Ruiz-Cardozo, Miguel A., Gu, Xingxing, Weizman Shapira, Tal, Rustenhoven, Justin, Molina, Camilo, Smirnov, Igor, Merbl, Yifat, Ray, Wilson Z., Kipnis, Jonathan

“…Traumatic injuries to the central nervous system (CNS) afflict millions of individuals worldwide 1 , yet an effective treatment remains elusive. Following such…”
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A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages by Brioschi, Simone, Belk, Julia A., Peng, Vincent, Molgora, Martina, Rodrigues, Patrick Fernandes, Nguyen, Khai M., Wang, Shoutang, Du, Siling, Wang, Wei-Le, Grajales-Reyes, Gary E., Ponce, Jennifer M., Yuede, Carla M., Li, Qingyun, Baer, John M., DeNardo, David G., Gilfillan, Susan, Cella, Marina, Satpathy, Ansuman T., Colonna, Marco

“…Genetic tools to target microglia specifically and efficiently from the early stages of embryonic development are lacking. We generated a constitutive Cre line…”
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Optimization of the Irf8 +32-kb enhancer disrupts dendritic cell lineage segregation by Ou, Feiya, Liu, Tian-Tian, Desai, Pritesh, Ferris, Stephen T., Kim, Sunkyung, Shen, Haolin, Ohara, Ray A., Jo, Suin, Chen, Jing, Postoak, J. Luke, Du, Siling, Diamond, Michael S., Murphy, Theresa L., Murphy, Kenneth M.

“…Autoactivation of lineage-determining transcription factors mediates bistable expression, generating distinct cell phenotypes essential for complex body plans…”
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Three new species Nothopoda Keifer (Acari, Nothopodinae) from Guangxi, China by Lv, Ankang, Deng, Xinyan, Zhao, Yunzhe, Du, Siling, Tan, Mengchao, Wang, Guoquan

“…In this paper, three new species of eriophyoid mites belonging to the subfamily Nothopodinae from Guangxi are described and illustrated. They are Nothopoda…”
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Saturated fatty acids increase LPI to reduce FUNDC1 dimerization and stability and mitochondrial function by Chen, Linbo, Zhang, Qianping, Meng, Yuanyuan, Zhao, Tian, Mu, Chenglong, Fu, Changying, Deng, Caijuan, Feng, Jianyu, Du, Siling, Liu, Wei, Geng, Guangfeng, Ma, Kaili, Cheng, Hongcheng, Liu, Qiangqiang, Luo, Qian, Zhang, Jiaojiao, Du, Zhanqiang, Cao, Lin, Wang, Hui, Liu, Yong, Lin, Jianping, Chen, Guo, Liu, Lei, Lam, Sin Man, Shui, Guanghou, Zhu, Yushan, Chen, Quan

“…Ectopic lipid deposition and mitochondrial dysfunction are common etiologies of obesity and metabolic disorders. Excessive dietary uptake of saturated fatty…”
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Parenchymal border macrophages regulate CSF flow dynamics by Drieu, Antoine, Du, Siling, Storck, Steffen E., Rustenhoven, Justin, Papadopoulos, Zachary, Dykstra, Taitea, Zhong, Fenghe, Kim, Kyungdeok, Blackburn, Susan, Mamuladze, Tornike, Harari, Oscar, Karch, Celeste M., Bateman, Randall J., Perrin, Richard, Farlow, Martin, Chhatwal, Jasmeer, Hu, Song, Randolph, Gwendalyn J., Smirnov, Igor, Kipnis, Jonathan

“…Macrophages are important players for the maintenance of tissue homeostasis 1 . Perivascular and leptomeningeal macrophages reside in close proximity to the…”
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TREM2 Drives Microglia Response to Amyloid-β via SYK-dependent and -independent Paths by Wang, Shoutang, Sudan, Raki, Peng, Vincent, Zhou, Yingyue, Du, Siling, Yuede, Carla M., Lei, Tingting, Hou, Jinchao, Cai, Zhangying, Cella, Marina, Nguyen, Khai, Poliani, Pietro L., Beatty, Wandy L., Chen, Yun, Cao, Siyan, Lin, Kent, Rodrigues, Cecilia, Ellebedy, Ali H., Gilfillan, Susan, Brown, Gordon D., Holtzman, David M., Brioschi, Simone, Colonna, Marco

“…Genetic studies have highlighted microglia as pivotal in orchestrating Alzheimer’s disease (AD). Microglia that adhere to Aβ plaques acquire a transcriptional…”
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Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid by Drieu, Antoine, Du, Siling, Storck, Steffen E., Rustenhoven, Justin, Papadopoulos, Zachary, Dykstra, Taitea, Zhong, Fenghe, Kim, Kyungdeok, Blackburn, Susan, Mamuladze, Tornike, Harari, Oscar, Karch, Celeste M., Bateman, Randall J., Perrin, Richard, Farlow, Martin, Chhatwal, Jasmeer, Brosch, Jared, Buck, Jill, Farlow, Marty, Ghetti, Bernardino, Adams, Sarah, Barthelemy, Nicolas, Benzinger, Tammie, Brandon, Susan, Buckles, Virginia, Cash, Lisa, Chen, Charlie, Chua, Jasmin, Cruchaga, Carlos, Denner, Darcy, Dincer, Aylin, Donahue, Tamara, Fagan, Anne, Feldman, Becca, Flores, Shaney, Franklin, Erin, Joseph-Mathurin, Nelly, Gonzalez, Alyssa, Gordon, Brian, Gray, Julia, Gremminger, Emily, Groves, Alex, Hassenstab, Jason, Hellm, Cortaiga, Herries, Elizabeth, Hoechst-Swisher, Laura, Holtzman, David, Hornbeck, Russ, Jerome, Gina, Keefe, Sarah, Koudelis, Deb, Li, Yan, Marsh, Jacob, Martinez, Rita, Mawuenyega, Kwasi, McCullough, Austin, McDade, Eric, Morris, John, Norton, Joanne, Shady, Kristine, Sigurdson, Wendy, Smith, Jennifer, Wang, Peter, Wang, Qing, Xiong, Chengjie, Xu, Jinbin, Xu, Xiong, Allegri, Ricardo, Mendez, Patricio Chrem, Egido, Noelia, Araki, Aki, Ikeuchi, Takeshi, Ishii, Kenji, Kasuga, Kensaku, Bechara, Jacob, Brooks, William, Schofield, Peter, Berman, Sarah, Goldberg, Sarah, Ikonomovic, Snezana, Klunk, William, Lopez, Oscar, Mountz, James, Nadkarni, Neelesh, Patira, Riddhi, Smith, Lori, Snitz, Beth, Thompson, Sarah, Weamer, Elise, Bodge, Courtney, Salloway, Stephen, Carter, Kathleen, Duong, Duc, Johnson, Erik, Levey, Allan, Ping, Lingyan, Seyfried, Nicholas T., Fitzpatrick, Colleen, Chui, Helena, Ringman, John

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Parenchymal border macrophages regulate tau pathology and tau-mediated neurodegeneration by Drieu, Antoine, Du, Siling, Kipnis, Michal, Bosch, Megan E, Herz, Jasmin, Lee, Choonghee, Jiang, Hong, Manis, Melissa, Ulrich, Jason D, Kipnis, Jonathan, Holtzman, David M, Gratuze, Maud

“…Parenchymal border macrophages (PBMs) reside close to the central nervous system parenchyma and regulate CSF flow dynamics. We recently demonstrated that PBMs…”
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