Search Results - "Du, Shisuo"

ALKBH5-Modified HMGB1-STING Activation Contributes to Radiation Induced Liver Disease via Innate Immune Response by Chen, Genwen, Zhao, Qianqian, Yuan, Baoying, Wang, Biao, Zhang, Yang, Li, Zongjuan, Du, Shisuo, Zeng, Zhaochong

“…Radiation therapy, which is vital for the treatment of primary liver cancer, comes with unavoidable liver injury, which limits its implementation…”
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DNA sensing and associated type 1 interferon signaling contributes to progression of radiation-induced liver injury by Du, Shisuo, Chen, Genwen, Yuan, Baoying, Hu, Yong, Yang, Ping, Chen, Yixing, Zhao, Qianqian, Zhou, Jian, Fan, Jia, Zeng, Zhaochong

“…Liver damage upon exposure to ionizing radiation (IR), whether accidental or therapeutic, can contribute to liver dysfunction. Currently, radiotherapy (RT) is…”
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Blockade of Tumor-Expressed PD-1 promotes lung cancer growth by Du, Shisuo, McCall, Neal, Park, Kyewon, Guan, Qing, Fontina, Paolo, Ertel, Adam, Zhan, Tingting, Dicker, Adam P, Lu, Bo

“…Anti-PD-1 immunotherapy is the standard of care for treating many patients with non-small cell lung cancer (NSCLC), yet mechanisms of treatment failure are…”
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Gut microbiota modulate radiotherapy-associated antitumor immune responses against hepatocellular carcinoma Via STING signaling by Li, Zongjuan, Zhang, Yang, Hong, Weifeng, Wang, Biao, Chen, Yixing, Yang, Ping, Zhou, Jian, Fan, Jia, Zeng, Zhaochong, Du, Shisuo

“…Studies of the gut-liver axis have enhanced our understanding of the pathophysiology of various liver diseases and the mechanisms underlying the regulation of…”
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Radiotherapy enhances efficacy of PD-1 inhibitors in advanced hepatocellular carcinoma: A propensity-matched real-world study by Hsu, Shujung, Chao, Yencheng, Hu, Yong, Zhang, Yang, Hong, Weifeng, Chen, Yixing, Chen, Rongxin, Zeng, Zhaochong, Du, Shisuo

“…To address the need for immunotherapy in patients with advanced primary hepatocellular carcinoma (HCC), combination with radiotherapy (RT) has emerged as a…”
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Treatment-duration is related to changes in peripheral lymphocyte counts during definitive radiotherapy for unresectable stage III NSCLC by Zhao, Qianqian, Chen, Gang, Ye, Luxi, Shi, Shiming, Du, Shisuo, Zeng, Zhaochong, He, Jian

“…To investigate the potential impact of fractionation regimes and overall treatment time (OTT) on lymphopenia during definitive radiotherapy (RT) and its…”
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Localized microbubble cavitation-based antivascular therapy for improving HCC treatment response to radiotherapy by Daecher, Annemarie, Stanczak, Maria, Liu, Ji-Bin, Zhang, Jie, Du, Shisuo, Forsberg, Flemming, Leeper, Dennis B., Eisenbrey, John R.

“…Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide and the fastest growing malignancy in the United States. With a 5-year…”
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Deep dissection of stemness-related hierarchies in hepatocellular carcinoma by Liang, Rui, Hong, Weifeng, Zhang, Yang, Ma, Di, Li, Jinwei, Shi, Yisong, Luo, Qing, Du, Shisuo, Song, Guanbin

“…Abstract Background Increasing evidence suggests that hepatocellular carcinoma (HCC) stem cells (LCSCs) play an essential part in HCC recurrence, metastasis,…”
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Shortened Radiation Time Promotes Recovery From Radiation-induced Lymphopenia in Early-Stage Non-small Cell Lung Cancer Patients Treated With Stereotactic Body Radiation Therapy by Zhao, Qianqian, Li, Tingting, Du, Shisuo, He, Jian, Zeng, Zhaochong

“…Background: To evaluate the potential impact of radiation time on radiation-induced lymphopenia (RIL) and subsequently recovery after stereotactic body…”
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Induction Strategy for Locally Advanced Thymoma by Zhang, Yang, Li, Zongjuan, Chen, Yixing, Tan, Lijie, Zeng, Zhaochong, Ding, Jianyong, Du, Shisuo

“…Surgery remains cornerstone for the management of thymoma. Complete surgical resection (R0), is recognized as the constant and significant factor for…”
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Higher serum sPD-L1 levels after radiotherapy indicate poor outcome in hepatocellular carcinoma patients by Zhang, Yang, Li, Zongjuan, Chen, Yixing, Yang, Ping, Hu, Yong, Zeng, Zhaochong, Du, Shisuo

“…•RT increases serum soluble PD-L1 levels in hepatocellular carcinoma.•Increased serum PD-L1 levels post-RT noted immune suppression effects.•Higher post-RT…”
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Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non–Small-Cell Lung Cancer Cells In Vitro and In Vivo by Du, Shisuo, MD, PhD, Bouquet, Sophie, PhD, Lo, Chen-Hao, MS, Pellicciotta, Ilenia, PhD, Bolourchi, Shiva, MS, Parry, Renate, PhD, Barcellos-Hoff, Mary Helen, PhD

“…Purpose To determine whether transforming growth factor (TGF)-β inhibition increases the response to radiation therapy in human and mouse non–small-cell lung…”
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Tumors as Organs: Biologically Augmenting Radiation Therapy by Inhibiting Transforming Growth Factor β Activity in Carcinomas by Du, Shisuo, MD, PhD, Barcellos-Hoff, Mary Helen, PhD

“…Transforming growth factor β (TGFβ) plays critical roles in regulating a plethora of physiological processes in normal organs, including morphogenesis,…”
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Induction Therapy Followed by Surgery for Unresectable Thymic Epithelial Tumours by Wang, Shuai, Jiang, Jiahao, Gao, Jian, Chen, Gang, Fan, Yue, Xu, Bei, Dong, Jihong, Du, Shisuo, Liu, Junzhen, Ding, Jianyong

“…The treatment of unresectable thymic epithelial tumours (TETs) remains controversial. Here, we present the efficacy and safety of induction therapy followed by…”
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Nomogram for predicting cancer specific survival in inflammatory breast carcinoma: a SEER population-based study by Zhang, Haige, Ma, Guifen, Du, Shisuo, Sun, Jing, Zhang, Qian, Yuan, Baoying, Luo, Xiaoyong

“…The clinicopathological features of inflammatory breast carcinoma (IBC), the effect of therapeutic options on survival outcome and the identification of…”
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Additional adjuvant radiotherapy improves survival at 1 year after surgical treatment for pancreatic cancer patients with T4, N2 disease, positive resection margin, and receiving adjuvant chemotherapy by Wu, Lili, Xu, Yaolin, Zhou, Yuhong, Zeng, Zhaochong, Fan, Yue, Wang, Dansong, Wu, Wenchuan, Guo, Xi, Lv, Minzhi, Ouyang, Yuxiu, Du, Shisuo, Lou, Wenhui

“…Background While adjuvant chemotherapy has been established as standard practice following radical resection of pancreatic ductal adenocarcinoma (PDAC), the…”
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Comparison of long-term outcomes of stereotactic body radiotherapy (SBRT) via Helical tomotherapy for early-stage lung cancer with or without pathological proof by Fan, Shaonan, Zhang, Qi, Chen, Jingyao, Chen, Gang, Zhu, Jiangyi, Li, Tingting, Xiao, Han, Du, Shisuo, Zeng, Zhaochong, He, Jian

“…Stereotactic body radio therapy (SBRT) has emerged as a standard treatment option for nonsurgical candidates with early-stage non-small cell lung cancer…”
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RECQL4 Inhibits Radiation‐Induced Tumor Immune Awakening via Suppressing the cGAS‐STING Pathway in Hepatocellular Carcinoma by Hong, Weifeng, Zhang, Yang, Wang, Siwei, Li, Zongjuan, Zheng, Danxue, Hsu, Shujung, Zhou, Jian, Fan, Jia, Chen, Zhesheng, Xia, Xiaojun, Zeng, Zhaochong, Gao, Qiang, Yu, Min, Du, Shisuo

“…Many patients with hepatocellular carcinoma (HCC) respond poorly to radiotherapy despite remarkable advances in treatment. A deeper insight into the mechanism…”
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Melanoma Derived Exosomes Amplify Radiotherapy Induced Abscopal Effect via IRF7/I‐IFN Axis in Macrophages by Wang, Lu, Shen, Kangjie, Gao, Zixu, Ren, Ming, Wei, Chenlu, Yang, Yang, Li, Yinlam, Zhu, Yu, Zhang, Simin, Ding, Yiteng, Zhang, Tianyi, Li, Jianrui, Zhu, Ming, Zheng, Shaoluan, Yang, Yanwen, Du, Shisuo, Wei, Chuanyuan, Gu, Jianying

“…Radiotherapy (RT) can induce tumor regression outside the irradiation field, known as the abscopal effect. However, the detailed underlying mechanisms remain…”
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Consolidative Chemoradiotherapy After Induced Chemotherapy Is an Optimal Regimen for Locally Advanced Pancreatic Cancer by Wu, Lili, Zhou, Yuhong, Fan, Yue, Rao, Shengxiang, Ji, Yuan, Sun, Jing, Li, Tingting, Du, Shisuo, Guo, Xi, Zeng, Zhaochong, Lou, Wenhui

“…To evaluate the efficacy and tolerability of consolidative chemoradiotherapy (cCRT) after induced chemotherapy (iCT) for locally advanced pancreatic cancer…”
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