Search Results - "Du, Likun"

piRNAs: biogenesis and their potential roles in cancer by Guo, Binghong, Li, Dongpei, Du, Likun, Zhu, Xiao

“…With the length of about 26–31 nt, PIWI-interacting RNA (piRNA) is a small non-coding RNA (ncRNA) that interacts with PIWI proteins to form the piRNA silencing…”
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Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant by Zuo, Fanglei, Abolhassani, Hassan, Du, Likun, Piralla, Antonio, Bertoglio, Federico, de Campos-Mata, Leire, Wan, Hui, Schubert, Maren, Cassaniti, Irene, Wang, Yating, Sammartino, Josè Camilla, Sun, Rui, Vlachiotis, Stelios, Bergami, Federica, Kumagai-Braesch, Makiko, Andréll, Juni, Zhang, Zhaoxia, Xue, Yintong, Wenzel, Esther Veronika, Calzolai, Luigi, Varani, Luca, Rezaei, Nima, Chavoshzadeh, Zahra, Baldanti, Fausto, Hust, Michael, Hammarström, Lennart, Marcotte, Harold, Pan-Hammarström, Qiang

“…The recent emergence of the Omicron variant has raised concerns on vaccine efficacy and the urgent need to study more efficient vaccination strategies. Here we…”
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Tumor-infiltrating lymphocytes: Warriors fight against tumors powerfully by Lin, Baisheng, Du, Likun, Li, Hongmei, Zhu, Xiao, Cui, Liao, Li, Xiaosong

“…•The development of neoplastic infiltrating lymphocytes.•Preparation of tumor infiltrating lymphocytes.•The application of tumor infiltrating lymphocytes in…”
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Three-dimensional genome: developmental technologies and applications in precision medicine by Li, Yingqi, Tao, Tao, Du, Likun, Zhu, Xiao

“…In the 20th century, our familiar structure of DNA was the double helix. Due to technical limitations, we do not have a good way to understand the finer…”
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EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay by Volpi, Stefano, Yamazaki, Yasuhiro, Brauer, Patrick M, van Rooijen, Ellen, Hayashida, Atsuko, Slavotinek, Anne, Sun Kuehn, Hye, Di Rocco, Maja, Rivolta, Carlo, Bortolomai, Ileana, Du, Likun, Felgentreff, Kerstin, Ott de Bruin, Lisa, Hayashida, Kazutaka, Freedman, George, Marcovecchio, Genni Enza, Capuder, Kelly, Rath, Prisni, Luche, Nicole, Hagedorn, Elliott J, Buoncompagni, Antonella, Royer-Bertrand, Beryl, Giliani, Silvia, Poliani, Pietro Luigi, Imberti, Luisa, Dobbs, Kerry, Poulain, Fabienne E, Martini, Alberto, Manis, John, Linhardt, Robert J, Bosticardo, Marita, Rosenzweig, Sergio Damian, Lee, Hane, Puck, Jennifer M, Zúñiga-Pflücker, Juan Carlos, Zon, Leonard, Park, Pyong Woo, Superti-Furga, Andrea, Notarangelo, Luigi D

“…We studied three patients with severe skeletal dysplasia, T cell immunodeficiency, and developmental delay. Whole-exome sequencing revealed homozygous missense…”
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Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia by Boisson, Bertrand, Laplantine, Emmanuel, Dobbs, Kerry, Cobat, Aurélie, Tarantino, Nadine, Hazen, Melissa, Lidov, Hart G W, Hopkins, Gregory, Du, Likun, Belkadi, Aziz, Chrabieh, Maya, Itan, Yuval, Picard, Capucine, Fournet, Jean-Christophe, Eibel, Hermann, Tsitsikov, Erdyni, Pai, Sung-Yun, Abel, Laurent, Al-Herz, Waleed, Casanova, Jean-Laurent, Israel, Alain, Notarangelo, Luigi D

“…Inherited, complete deficiency of human HOIL-1, a component of the linear ubiquitination chain assembly complex (LUBAC), underlies autoinflammation,…”
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Deleterious Mutations in LRBA Are Associated with a Syndrome of Immune Deficiency and Autoimmunity by Lopez-Herrera, Gabriela, Tampella, Giacomo, Pan-Hammarström, Qiang, Herholz, Peer, Trujillo-Vargas, Claudia M., Phadwal, Kanchan, Simon, Anna Katharina, Moutschen, Michel, Etzioni, Amos, Mory, Adi, Srugo, Izhak, Melamed, Doron, Hultenby, Kjell, Liu, Chonghai, Baronio, Manuela, Vitali, Massimiliano, Philippet, Pierre, Dideberg, Vinciane, Aghamohammadi, Asghar, Rezaei, Nima, Enright, Victoria, Du, Likun, Salzer, Ulrich, Eibel, Hermann, Pfeifer, Dietmar, Veelken, Hendrik, Stauss, Hans, Lougaris, Vassilios, Plebani, Alessandro, Gertz, E. Michael, Schäffer, Alejandro A., Hammarström, Lennart, Grimbacher, Bodo

“…Most autosomal genetic causes of childhood-onset hypogammaglobulinemia are currently not well understood. Most affected individuals are simplex cases, but both…”
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Genome-wide CRISPR screens reveal synthetic lethal interaction between CREBBP and EP300 in diffuse large B-cell lymphoma by Nie, Man, Du, Likun, Ren, Weicheng, Joung, Julia, Ye, Xiaofei, Shi, Xi, Ciftci, Sibel, Liu, Dongbing, Wu, Kui, Zhang, Feng, Pan-Hammarström, Qiang

“…Diffuse large B-cell lymphoma (DLBCL) is the most common type of aggressive lymphoid malignancy and a highly heterogeneous disease. In this study, we performed…”
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Human serum from SARS-CoV-2-vaccinated and COVID-19 patients shows reduced binding to the RBD of SARS-CoV-2 Omicron variant by Schubert, Maren, Bertoglio, Federico, Steinke, Stephan, Heine, Philip Alexander, Ynga-Durand, Mario Alberto, Maass, Henrike, Sammartino, Josè Camilla, Cassaniti, Irene, Zuo, Fanglei, Du, Likun, Korn, Janin, Milošević, Marko, Wenzel, Esther Veronika, Krstanović, Fran, Polten, Saskia, Pribanić-Matešić, Marina, Brizić, Ilija, Baldanti, Fausto, Hammarström, Lennart, Dübel, Stefan, Šustić, Alan, Marcotte, Harold, Strengert, Monika, Protić, Alen, Piralla, Antonio, Pan-Hammarström, Qiang, Čičin-Šain, Luka, Hust, Michael

“…The COVID-19 pandemic is caused by the betacoronavirus SARS-CoV-2. In November 2021, the Omicron variant was discovered and immediately classified as a variant…”
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Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency by Abolhassani, Hassan, Edwards, Emily S J, Ikinciogullari, Aydan, Jing, Huie, Borte, Stephan, Buggert, Marcus, Du, Likun, Matsuda-Lennikov, Mami, Romano, Rosa, Caridha, Rozina, Bade, Sangeeta, Zhang, Yu, Frederiksen, Juliet, Fang, Mingyan, Bal, Sevgi Kostel, Haskologlu, Sule, Dogu, Figen, Tacyildiz, Nurdan, Matthews, Helen F, McElwee, Joshua J, Gostick, Emma, Price, David A, Palendira, Umaimainthan, Aghamohammadi, Asghar, Boisson, Bertrand, Rezaei, Nima, Karlsson, Annika C, Lenardo, Michael J, Casanova, Jean-Laurent, Hammarström, Lennart, Tangye, Stuart G, Su, Helen C, Pan-Hammarström, Qiang

“…In this study, we describe four patients from two unrelated families of different ethnicities with a primary immunodeficiency, predominantly manifesting as…”
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Inherited IFNAR1 Deficiency in a Child with Both Critical COVID-19 Pneumonia and Multisystem Inflammatory Syndrome by Abolhassani, Hassan, Landegren, Nils, Bastard, Paul, Materna, Marie, Modaresi, Mohammadreza, Du, Likun, Aranda-Guillén, Maribel, Sardh, Fabian, Zuo, Fanglei, Zhang, Peng, Marcotte, Harold, Marr, Nico, Khan, Taushif, Ata, Manar, Al-Ali, Fatima, Pescarmona, Remi, Belot, Alexandre, Béziat, Vivien, Zhang, Qian, Casanova, Jean-Laurent, Kämpe, Olle, Zhang, Shen-Ying, Hammarström, Lennart, Pan-Hammarström, Qiang

“…Background Inborn errors of immunity (IEI) and autoantibodies to type I interferons (IFNs) underlie critical COVID-19 pneumonia in at least 15% of the…”
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The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining by Li, Conglei, Irrazabal, Thergiory, So, Clare C., Berru, Maribel, Du, Likun, Lam, Evelyn, Ling, Alexanda K., Gommerman, Jennifer L., Pan-Hammarström, Qiang, Martin, Alberto

“…Class switch recombination (CSR) has a fundamental function during humoral immune response and involves the induction and subsequent repair of DNA breaks in…”
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X-Linked TLR7 Deficiency Underlies Critical COVID-19 Pneumonia in a Male Patient with Ataxia-Telangiectasia by Abolhassani, Hassan, Vosughimotlagh, Ahmad, Asano, Takaki, Landegren, Nils, Boisson, Bertrand, Delavari, Samaneh, Bastard, Paul, Aranda-Guillén, Maribel, Wang, Yating, Zuo, Fanglei, Sardh, Fabian, Marcotte, Harold, Du, Likun, Zhang, Shen-Ying, Zhang, Qian, Rezaei, Nima, Kämpe, Olle, Casanova, Jean-Laurent, Hammarström, Lennart, Pan-Hammarström, Qiang

“…Background Coronavirus disease 2019 (COVID-19) exhibits a wide spectrum of clinical manifestations, ranging from asymptomatic to critical conditions…”
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Causal relationship between hypothyroidism and coronary atherosclerotic cardiovascular disease: a bidirectional two-sample Mendelian randomization by Li, Jiarui, Wang, Yihan, Luo, Xiaoting, Meng, Tianwei, Li, Chengjia, Li, Juan, Du, Likun

“…Background Epidemiological and observational studies demonstrate a comorbid relationship between hypothyroidism and atherosclerotic cardiovascular disease…”
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Functional analysis of naturally occurring DCLRE1C mutations and correlation with the clinical phenotype of ARTEMIS deficiency by Felgentreff, Kerstin, MD, Lee, Yu Nee, PhD, Frugoni, Francesco, PhD, Du, Likun, PhD, van der Burg, Mirjam, PhD, Giliani, Silvia, PhD, Tezcan, Ilhan, MD, Reisli, Ismail, MD, Mejstrikova, Ester, MD, de Villartay, Jean-Pierre, PhD, Sleckman, Barry P., MD, PhD, Manis, John, MD, PhD, Notarangelo, Luigi D., MD

“…Background The endonuclease ARTEMIS, which is encoded by the DCLRE1C gene, is a component of the nonhomologous end-joining pathway and participates in hairpin…”
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A review of the botany, phytochemistry, pharmacology, synthetic biology and comprehensive utilization of Silybum marianum by Zhang, Xiaozhuang, Liu, Meiqi, Wang, Zhen, Wang, Panpan, Kong, Lingyang, Wu, Jianhao, Wu, Wei, Ma, Lengleng, Jiang, Shan, Ren, Weichao, Du, Likun, Ma, Wei, Liu, Xiubo

“…(L.) Gaertn, a herbaceous plant with a long history in traditional medicine for the treatment of hepatobiliary diseases, particularly in Europe, which has…”
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Immunity to SARS-CoV-2 up to 15 months after infection by Marcotte, Harold, Piralla, Antonio, Zuo, Fanglei, Du, Likun, Cassaniti, Irene, Wan, Hui, Kumagai-Braesh, Makiko, Andréll, Juni, Percivalle, Elena, Sammartino, Josè Camilla, Wang, Yating, Vlachiotis, Stelios, Attevall, Janine, Bergami, Federica, Ferrari, Alessandro, Colaneri, Marta, Vecchia, Marco, Sambo, Margherita, Zuccaro, Valentina, Asperges, Erika, Bruno, Raffaele, Oggionni, Tiberio, Meloni, Federica, Abolhassani, Hassan, Bertoglio, Federico, Schubert, Maren, Calzolai, Luigi, Varani, Luca, Hust, Michael, Xue, Yintong, Hammarström, Lennart, Baldanti, Fausto, Pan-Hammarström, Qiang

“…Information concerning the longevity of immunity to SARS-CoV-2 following natural infection may have considerable implications for durability of immunity…”
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Design, structure and plasma binding of ancestral β-CoV scaffold antigens by Hueting, David, Schriever, Karen, Sun, Rui, Vlachiotis, Stelios, Zuo, Fanglei, Du, Likun, Persson, Helena, Hofström, Camilla, Ohlin, Mats, Walldén, Karin, Buggert, Marcus, Hammarström, Lennart, Marcotte, Harold, Pan-Hammarström, Qiang, Andréll, Juni, Syrén, Per-Olof

“…We report the application of ancestral sequence reconstruction on coronavirus spike protein, resulting in stable and highly soluble ancestral scaffold antigens…”
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Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency by Pan-Hammarström, Qiang, Hammarström, Lennart, Salzer, Ulrich, Du, Likun, Björkander, Janne, Cunningham-Rundles, Charlotte, Nelson, David L, Bacchelli, Chiara, Gaspar, H Bobby, Offer, Steven, Behrens, Timothy W, Grimbacher, Bodo

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DNA-PKcs Is Involved in Ig Class Switch Recombination in Human B Cells by Björkman, Andrea, Du, Likun, Felgentreff, Kerstin, Rosner, Cornelia, Pankaj Kamdar, Radhika, Kokaraki, Georgia, Matsumoto, Yoshihisa, Davies, E Graham, van der Burg, Mirjam, Notarangelo, Luigi D, Hammarström, Lennart, Pan-Hammarström, Qiang

“…Nonhomologous end-joining (NHEJ) is one of the major DNA double-strand break repair pathways in mammalian cells and is required for both V(D)J recombination…”
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