Search Results - "Du, Jiewen"

TCMIO: A Comprehensive Database of Traditional Chinese Medicine on Immuno-Oncology by Liu, Zhihong, Cai, Chuipu, Du, Jiewen, Liu, Bingdong, Cui, Lu, Fan, Xiude, Wu, Qihui, Fang, Jiansong, Xie, Liwei

“…Advances in immuno-oncology (IO) are making immunotherapy a powerful tool for cancer treatment. With the discovery of an increasing number of IO targets, many…”
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Systematic Studies on the Protocol and Criteria for Selecting a Covalent Docking Tool by Wen, Chang, Yan, Xin, Gu, Qiong, Du, Jiewen, Wu, Di, Lu, Yutong, Zhou, Huihao, Xu, Jun

“…With the resurgence of drugs with covalent binding mechanisms, much attention has been paid to docking methods for the discovery of targeted covalent…”
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Integrating FRAM and BN for enhanced resilience evaluation in construction emergency response: A scaffold collapse case study by Guo, Zihao, She, Jianjun, Li, Zhijian, Du, Jiewen, Ye, Song

“…The construction system's complexity can generate substantial uncertainties during emergencies. Resilience, as a new perspective on emergency response, can…”
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TCMAnalyzer: A Chemo- and Bioinformatics Web Service for Analyzing Traditional Chinese Medicine by Liu, Zhihong, Du, Jiewen, Yan, Xin, Zhong, Jiali, Cui, Lu, Lin, Jinyuan, Zeng, Lizhu, Ding, Peng, Chen, Pin, Zhou, Xinxin, Zhou, Huihao, Gu, Qiong, Xu, Jun

“…Traditional Chinese medicine (TCM) has been widely used and proven effective in long term clinical practice. However, the molecular mechanism of action for…”
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DenovoProfiling: A webserver for de novo generated molecule library profiling by Liu, Zhihong, Du, Jiewen, Lin, Ziying, Li, Ze, Liu, Bingdong, Cui, Zongbin, Fang, Jiansong, Xie, Liwei

“…[Display omitted] Various deep learning-based architectures for molecular generation have been proposed for de novo drug design. The flourish of the de novo…”
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Analysis of Spatial and Temporal Variations of the Near-Surface Wind Regime and Their Influencing Factors in the Badain Jaran Desert, China by Hu, Ziying, Wang, Guangpeng, Liu, Yong, Shi, Peijun, Zhang, Guoming, Liu, Jifu, Gu, Yu, Huang, Xichen, Zhang, Qingyan, Han, Xu, Wang, Xueling, Du, Jiewen, Li, Ruoxin, Liu, Lianyou

“…Wind regime is one of the main natural factors controlling the evolution and distribution of aeolian sand landforms, and sand drift potential (DP) is usually…”
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A Combination of Machine Learning and PBPK Modeling Approach for Pharmacokinetics Prediction of Small Molecules in Humans by Li, Yuelin, Wang, Zonghu, Li, Yuru, Du, Jiewen, Gao, Xiangrui, Li, Yuanpeng, Lai, Lipeng

“…Purpose: Recently, there has been rapid development in model-informed drug development, which has the potential to reduce animal experiments and accelerate…”
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An evaluation of factors influencing the community emergency management under compounding risks perspective by Li, Zhijian, She, Jianjun, Guo, Zihao, Du, Jiewen, Zhou, Yilun

“…Communities in China are proactive in emergency response, significantly mitigating compounding risks and enhancing resilience. There exists a crucial need to…”
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DeepScreening: a deep learning-based screening web server for accelerating drug discovery by Liu, Zhihong, Du, Jiewen, Fang, Jiansong, Yin, Yulong, Xu, Guohuan, Xie, Liwei

“…Deep learning contributes significantly to researches in biological sciences and drug discovery. Previous studies suggested that deep learning techniques have…”
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Predicting DPP-IV inhibitors with machine learning approaches by Cai, Jie, Li, Chanjuan, Liu, Zhihong, Du, Jiewen, Ye, Jiming, Gu, Qiong, Xu, Jun

“…Dipeptidyl peptidase IV (DPP-IV) is a promising Type 2 diabetes mellitus (T2DM) drug target. DPP-IV inhibitors prolong the action of glucagon-like peptide-1…”
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cBinderDB: a covalent binding agent database by Du, Jiewen, Yan, Xin, Liu, Zhihong, Cui, Lu, Ding, Peng, Tan, Xiaoqing, Li, Xiuming, Zhou, Huihao, Gu, Qiong, Xu, Jun

“…Small molecule drug candidates with attractive toxicity profiles that modulate target proteins through non-covalent interactions are usually favored by…”
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Application scenario-oriented molecule generation platform developed for drug discovery by Zheng, Lianjun, Shi, Fangjun, Peng, Chunwang, Xu, Min, Fan, Fangda, Li, Yuanpeng, Zhang, Lin, Du, Jiewen, Wang, Zonghu, Lin, Zhixiong, Sun, Yina, Deng, Chenglong, Duan, Xinli, Wei, Lin, Zhao, Chuanfang, Fang, Lei, Zhang, Peiyu, Ma, Songling, Lai, Lipeng, Yang, Mingjun

“…[Display omitted] •Here we present an application scenario-oriented platform (ID4Idea) for molecule generation in different scenarios of drug discovery. This…”
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Activation of pregnane X receptor sensitizes alcoholic steatohepatitis by transactivating fatty acid binding protein 4 by Zhang, Yiwen, Hu, Bingfang, Guan, Shaoxing, Li, Pan, Guo, Yingjie, Xu, Pengfei, Niu, Yongdong, Li, Yujin, Feng, Ye, Du, Jiewen, Xu, Jun, Guan, Xiuchen, Gu, Jingkai, Sun, Haiyan, Huang, Min

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Abstract 3525: Towards the efficient design of shared neoantigen peptide cancer vaccines using artificial intelligence by Zhang, Genwei, Du, Jiewen, Gao, Xiangrui, Wang, Tianyuan, Wang, Zhenghui, Zhang, Qingxia, Liu, Tongren, Chen, Dong, Zhu, Ruohan, Zhao, Yalong, Li, Chi Han Samson, Toh, Melvin, Lai, Lipeng

“…Abstract Background: The advent of immune checkpoint inhibitors has improved morbidity and mortality for some cancers, and recent breakthroughs in gene & cell…”
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Application scenario-oriented molecular generation platform developed for drug discovery by Zheng, Lianjun, Shi, Fangjun, Peng, Chunwang, Xu, Min, Fan, Fangda, Li, Yuanpeng, Zhang, Lin, Du, Jiewen, Wang, Zonghu, Lin, Zhixiong, Sun, Yina, Deng, Chenglong, Duan, Xinli, Wei, Lin, Zhao, Chuanfang, Fang, Lei, Zhang, Peiyu, Ma, Songling, Lai, Lipeng, Yang, Mingjun

“…Design of molecules for candidate compound selection is one of the central challenges in drug discovery due to the complexity of chemical space and requirement…”
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Load-Reducing Characteristics of Gas Screen During Underwater Launch of the Vehicle by SHI Yao, LU Jiewen, DU Xiaoxu, GAO Shan, REN Jinyi

“…During the underwater launching process, a gas screen channel is formed near the opening of the cylinder, which can effectively reduce the high-frequency…”
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REVOLUTIONIZING ANTIBODY DISCOVERY INDUSTRY WITH HIGHLY EFFICIENT AND ACCURATE AI-BASED EPITOPE-SPECIFIC ANTIBODY DE NOVO DESIGN WORKFLOW by Wang, Tianyuan, Gao, Xiangrui, Huai, Zhe, Gong, Zhaohui, Mao, Ting, Fan, Xuezhe, Wu, Xingxing, Duan, Zhiyuan, Wang, Xiaodong, Du, Jiewen, Yao, Mengcheng, Li, Xin, Wu, Min, Wang, Zonghu, Zhang, Lin, Zhang, Junjie, Cao, Wenbo, Yan, Kai, Fang, Yujie, Ma, Shixiang, Yang, Kun, Wu, Lili, An, Frank, Yang, Yi, Lai, Lipeng, Huang, Xiaolu

“…Abstract Background and significance The global antibody drug market is worth over $200 billion in 2021 and is expected to reach $380 billion by 2030. Antibody…”
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PTS: a pharmaceutical target seeker by Ding, Peng, Yan, Xin, Liu, Zhihong, Du, Jiewen, Du, Yunfei, Lu, Yutong, Wu, Di, Xu, Yuehua, Zhou, Huihao, Gu, Qiong, Xu, Jun

“…Identifying protein targets for a bioactive compound is critical in drug discovery. Molecular similarity is a main approach to fish drug targets, and is based…”
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REVOLUTIONIZING ANTIBODY DISCOVERY INDUSTRY WITH HIGHLY EFFICIENT AND ACCURATE AI-BASED EPITOPE-SPECIFIC ANTIBODY DE NOVO DESIGN WORKFLOW by Wang, Tianyuan, Gao, Xiangrui, Huai, Zhe, Gong, Zhaohui, Mao, Ting, Fan, Xuezhe, Wu, Xingxing, Duan, Zhiyuan, Wang, Xiaodong, Du, Jiewen, Yao, Mengcheng, Li, Xin, Wu, Min, Wang, Zonghu, Zhang, Lin, Zhang, Junjie, Cao, Wenbo, Yan, Kai, Fang, Yujie, Ma, Shixiang, Yang, Kun, Wu, Lili, An, Frank, Yang, Yi, Lai, Lipeng, Huang, Xiaolu

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