Search Results - "Du, Hansen"
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A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability
Published in Molecular cell (26-03-2010)“…FANCM remodels branched DNA structures and plays essential roles in the cellular response to DNA replication stress. Here, we show that FANCM forms a conserved…”
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Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells
Published in The Journal of experimental medicine (20-10-2014)“…Variable (V) genes of immunoglobulins undergo somatic hypermutation by activation-induced deaminase (AID) to generate amino acid substitutions that encode…”
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3
The U1 snRNP protein U1C recognizes the 5′ splice site in the absence of base pairing
Published in Nature (London) (05-09-2002)“…Splicing of precursor messenger RNA takes place in the spliceosome, a large RNA/protein macromolecular machine. Spliceosome assembly occurs in an ordered…”
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4
Misregulation of the IgH Locus in Thymocytes
Published in Frontiers in immunology (13-11-2018)“…Functional antigen receptor genes are assembled by somatic rearrangements that are largely lymphocyte lineage specific. The immunoglobulin heavy chain ( ) gene…”
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A Targeted Bypass Screen Identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for Stable U1 snRNP/Pre-mRNA Interaction
Published in Molecular and Cellular Biology (01-07-2009)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Activation of 12/23-RSS-Dependent RAG Cleavage by hSWI/SNF Complex in the Absence of Transcription
Published in Molecular cell (05-09-2008)“…Maintenance of genomic integrity during antigen receptor gene rearrangements requires (1) regulated access of the V(D)J recombinase to specific loci and (2)…”
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Using BAC transgenesis in zebrafish to identify regulatory sequences of the amyloid precursor protein gene in humans
Published in BMC genomics (04-09-2012)“…Non-coding DNA in and around the human Amyloid Precursor Protein (APP) gene that is central to Alzheimer's disease (AD) shares little sequence similarity with…”
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Nucleophosmin/B23 Negatively Regulates GCN5-dependent Histone Acetylation and Transactivation
Published in The Journal of biological chemistry (29-02-2008)“…Nucleophosmin/B23 is a multifunctional phosphoprotein that is overexpressed in cancer cells and has been shown to be involved in both positive and negative…”
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Effects of the U1C L13 mutation and temperature regulation of yeast commitment complex formation
Published in Proceedings of the National Academy of Sciences - PNAS (12-10-2004)“…The U1 small nuclear ribonucleoprotein particle U1C protein has a zinc finger-like structure (C2H2 motif) at its N terminus, which is conserved from yeast to…”
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10
Altered 3D chromatin structure permits inversional recombination at the IgH locus
Published in The Journal of immunology (1950) (01-05-2020)“…Abstract Immunoglobulin heavy chain (IgH) genes are assembled by two sequential DNA rearrangement events that are initiated by recombinase activating gene…”
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trp RNA-binding attenuation protein-5' stem-loop RNA interaction is required for proper transcription attenuation control of the Bacillus subtilis trpEDCFBA operon
Published in Journal of bacteriology (01-04-2000)“…The trp RNA-binding attenuation protein (TRAP) regulates expression of the Bacillus subtilis trpEDCFBA operon by a novel transcription attenuation mechanism…”
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12
Three-dimensional chromatin reorganization regulates B cell development during ageing
Published in Nature cell biology (01-06-2024)“…The contribution of three-dimensional genome organization to physiological ageing is not well known. Here we show that large-scale chromatin reorganization…”
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13
trp RNA-binding Attenuation Protein-mediated Long Distance RNA Refolding Regulates Translation of trpE inBacillus subtilis
Published in The Journal of biological chemistry (07-08-1998)“…Expression of the trpEDCFBA operon is regulated at both the transcriptional and translational levels by thetrp RNA-binding attenuation protein (TRAP)…”
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14
Sequential Enhancer Sequestration Dysregulates Recombination Center Formation at the IgH Locus
Published in Molecular cell (05-04-2018)“…Immunoglobulin heavy-chain (IgH) genes are assembled by DNA rearrangements that juxtapose a variable (VH), a diversity (DH), and a joining (JH) gene segment…”
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15
T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-γ
Published in Nature immunology (01-09-2009)“…The polarization of naive CD4 + T cells to become T helper type 2 cells requires the transcription factor GATA-3. Sen and colleagues show that T cell antigen…”
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Localized epigenetic changes induced by D sub(H) recombination restricts recombinase to DJ sub(H) junctions
Published in Nature immunology (01-12-2012)“…Genes encoding immunoglobulin heavy chains (Igh) are assembled by rearrangement of variable (V sub(H)), diversity (D sub(H)) and joining (J sub(H)) gene…”
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Localized epigenetic changes induced by [D.sub.H] recombination restricts recombinase to [DJ.sub.H] junctions
Published in Nature immunology (01-12-2012)“…Genes encoding immunoglobulin heavy chains (Igh) are assembled by rearrangement of variable [(V.sub.H]), diversity [(D.sub.H]) and joining [(J.sub.H]) gene…”
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18
Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions
Published in Nature immunology (01-12-2012)“…The Igh locus undergoes a precise order of gene rearrangement during V(D)J recombination. Sen and colleagues show the recruitment of the RAG recombinase is…”
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Mi2β Shows Chromatin Enzyme Specificity by Erasing a DNase I-hypersensitive Site Established by ACF
Published in The Journal of biological chemistry (20-03-2009)“…ATP-dependent chromatin-remodeling enzymes are linked to changes in gene expression; however, it is not clear how the multiple remodeling enzymes found in…”
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Mi2β Shows Chromatin Enzyme Specificity by Erasing a DNase I-hypersensitive Site Established by ACFS
Published in The Journal of biological chemistry (20-03-2009)“…ATP-dependent chromatin-remodeling enzymes are linked to changes in gene expression; however, it is not clear how the multiple remodeling enzymes found in…”
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