Search Results - "Du, Guocheng"

Regulation of Sensing, Transportation, and Catabolism of Nitrogen Sources in Saccharomyces cerevisiae by Zhang, Weiping, Du, Guocheng, Zhou, Jingwen, Chen, Jian

“…Nitrogen is one of the most important essential nutrient sources for biogenic activities. Regulation of nitrogen metabolism in microorganisms is complicated…”
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Eliminating the capsule-like layer to promote glucose uptake for hyaluronan production by engineered Corynebacterium glutamicum by Wang, Yang, Hu, Litao, Huang, Hao, Wang, Hao, Zhang, Tianmeng, Chen, Jian, Du, Guocheng, Kang, Zhen

“…Hyaluronan is widely used in cosmetics and pharmaceutics. Development of robust and safe cell factories and cultivation approaches to efficiently produce…”
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Enhancing flavonoid production by systematically tuning the central metabolic pathways based on a CRISPR interference system in Escherichia coli by Wu, Junjun, Du, Guocheng, Chen, Jian, Zhou, Jingwen

“…The limited supply of intracellular malonyl-CoA in Escherichia coli impedes the biological synthesis of polyketides, flavonoids and biofuels. Here, a clustered…”
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The challenges and prospects of Escherichia coli as an organic acid production host under acid stress by Yang, Jinhua, Zhang, Juan, Zhu, Zhengming, Du, Guocheng

“…Objective Organic acids have a wide range of applications and have attracted the attention of many industries, and their large-scale applications have led…”
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Fate of antibiotics, antibiotic-resistant bacteria, and cell-free antibiotic-resistant genes in full-scale membrane bioreactor wastewater treatment plants by Wang, Shuo, Ma, Xinxin, Liu, Yalan, Yi, Xuesong, Du, Guocheng, Li, Ji

“…•Antibiotics removal favored biodegradation over bioadsorption by full-scale MBR.•Aeromonas performed specific antibiotic resistance to AMP and ERY.•Klebsiella…”
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Pyruvate-responsive genetic circuits for dynamic control of central metabolism by Xu, Xianhao, Li, Xueliang, Liu, Yanfeng, Zhu, Yonglian, Li, Jianghua, Du, Guocheng, Chen, Jian, Ledesma-Amaro, Rodrigo, Liu, Long

“…Dynamic regulation is a promising strategy for fine-tuning metabolic fluxes in microbial cell factories. However, few of these synthetic regulatory systems…”
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Synthetic Biology Toolbox and Chassis Development in Bacillus subtilis by Liu, Yanfeng, Liu, Long, Li, Jianghua, Du, Guocheng, Chen, Jian

“…Based on technical advances in the sequencing and synthesis of genetic components as well as the genome, significant progress has recently been made in…”
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Optimization of the heme biosynthesis pathway for the production of 5-aminolevulinic acid in Escherichia coli by Zhang, Junli, Kang, Zhen, Chen, Jian, Du, Guocheng

“…5-Aminolevulinic acid (ALA), the committed intermediate of the heme biosynthesis pathway, shows significant promise for cancer treatment. Here, we identified…”
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Microbial Chassis Development for Natural Product Biosynthesis by Xu, Xianhao, Liu, Yanfeng, Du, Guocheng, Ledesma-Amaro, Rodrigo, Liu, Long

“…Engineering microbial cells to efficiently synthesize high-value-added natural products has received increasing attention in recent years. In this review, we…”
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Efficient Biosynthesis of (2S)‑Naringenin from p‑Coumaric Acid in Saccharomyces cerevisiae by Gao, Song, Lyu, Yunbin, Zeng, Weizhu, Du, Guocheng, Zhou, Jingwen, Chen, Jian

“…(2S)-Naringenin, a (2S)-flavanone, is widely used in the food, chemical, and pharmaceutical industries because of its diverse physiological activities. The…”
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Advances and prospects of Bacillus subtilis cellular factories: From rational design to industrial applications by Gu, Yang, Xu, Xianhao, Wu, Yaokang, Niu, Tengfei, Liu, Yanfeng, Li, Jianghua, Du, Guocheng, Liu, Long

“…Bacillus subtilis is the most characterized gram-positive bacterium that has significant attributes, such as growing well on cheap carbon sources, possessing…”
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Engineering of multiple modular pathways for high-yield production of 5-aminolevulinic acid in Escherichia coli by Zhang, Junli, Weng, Huanjiao, Zhou, Zhengxiong, Du, Guocheng, Kang, Zhen

“…•Balancing the expression of hemA and hemL by mutating RBS improved ALA synthesis.•ALA catabolism was weakened by substituting the promoter of hemB with…”
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Microbial production of hyaluronic acid: current state, challenges, and perspectives by Liu, Long, Liu, Yanfeng, Li, Jianghua, Du, Guocheng, Chen, Jian

“…Hyaluronic acid (HA) is a natural and linear polymer composed of repeating disaccharide units of β-1, 3-N-acetyl glucosamine and β-1, 4-glucuronic acid with a…”
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Metabolic engineering in the biotechnological production of organic acids in the tricarboxylic acid cycle of microorganisms: Advances and prospects by Yin, Xian, Li, Jianghua, Shin, Hyun-dong, Du, Guocheng, Liu, Long, Chen, Jian

“…Organic acids, which are chemically synthesized, are also natural intermediates in the metabolic pathways of microorganisms, among which the tricarboxylic acid…”
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Growth-coupled evolution and high-throughput screening assisted rapid enhancement for amylase-producing Bacillus licheniformis by Zhang, Guoqiang, Chen, Yukun, Li, Qinghua, Zhou, Jingwen, Li, Jianghua, Du, Guocheng

“…[Display omitted] •Growth-coupled adaptive evolution enhanced amylase production of B. licheniformis.•High-yield single strains were selected by droplet…”
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Metabolic engineering for the synthesis of steviol glycosides: current status and future prospects by Zhou, Xuan, Gong, Mengyue, Lv, Xueqin, Liu, Yanfeng, Li, Jianghua, Du, Guocheng, Liu, Long

“…With the pursuit of natural non-calorie sweeteners, steviol glycosides (SGs) have become one of the most popular natural sweeteners in the market. The SGs in…”
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Keratin Waste Recycling Based on Microbial Degradation: Mechanisms and Prospects by Peng, Zheng, Zhang, Juan, Du, Guocheng, Chen, Jian

“…The severe shortage of protein resources has motivated researchers to seek cheap and sustainable proteins and to produce new functional materials in an…”
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Molecular engineering of chitinase from Bacillus sp. DAU101 for enzymatic production of chitooligosaccharides by Pan, Mengyan, Li, Jianghua, Lv, Xueqin, Du, Guocheng, Liu, Long

“…[Display omitted] •Successfully achieved heterologous expression of Chisb in B. subtilis WB600. • Chisb was secreted outside of the cell by NprB signal…”
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Modular optimization of heterologous pathways for de novo synthesis of (2S)-naringenin in Escherichia coli by Wu, Junjun, Zhou, Tiantian, Du, Guocheng, Zhou, Jingwen, Chen, Jian

“…Due to increasing concerns about food safety and environmental issues, bio-based production of flavonoids from safe, inexpensive, and renewable substrates is…”
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De novo biosynthesis of rubusoside and rebaudiosides in engineered yeasts by Xu, Yameng, Wang, Xinglong, Zhang, Chenyang, Zhou, Xuan, Xu, Xianhao, Han, Luyao, Lv, Xueqin, Liu, Yanfeng, Liu, Song, Li, Jianghua, Du, Guocheng, Chen, Jian, Ledesma-Amaro, Rodrigo, Liu, Long

“…High-sugar diet causes health problems, many of which can be addressed with the use of sugar substitutes. Rubusoside and rebaudiosides are interesting…”
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