Search Results - "Drysdale, J."

The relationship between risk factors and medication adherence among breast cancer survivors: What explanatory role might depression play? by Markovitz, Louis C., Drysdale, Nicholas J., Bettencourt, B. Ann

“…Objective Despite the efficacy of clinical treatments (eg, adjuvant hormonal therapy) for breast cancer survivors (BCS), nonadherence rates remain high,…”
Get full text

novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells by Massey, Andrew J, Williamson, Douglas S, Browne, Helen, Murray, James B, Dokurno, Pawel, Shaw, Terry, Macias, Alba T, Daniels, Zoe, Geoffroy, Stephanie, Dopson, Melanie, Lavan, Paul, Matassova, Natalia, Francis, Geraint L, Graham, Christopher J, Parsons, Rachel, Wang, Yikang, Padfield, Antony, Comer, Mike, Drysdale, Martin J, Wood, Mike

“…Purpose The anti-apoptotic function of the 70 kDa family of heat shock proteins and their role in cancer is well documented. Dual targeting of Hsc70 and Hsp70…”
Get full text

Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design by Dymock, Brian W, Barril, Xavier, Brough, Paul A, Cansfield, Julie E, Massey, Andrew, McDonald, Edward, Hubbard, Roderick E, Surgenor, Allan, Roughley, Stephen D, Webb, Paul, Workman, Paul, Wright, Lisa, Drysdale, Martin J

“…The crystal structure of a previously reported screening hit 1 (CCT018159) bound to the N terminal domain of molecular chaperone Hsp90 has been used to design…”
Get full text

Cannabidiol-induced intracellular Ca2+ elevations in hippocampal cells by Drysdale, Alison J, Ryan, Duncan, Pertwee, Roger G, Platt, Bettina

“…The phytocannabinoid cannabidiol (CBD) is at the forefront of therapeutic cannabinoid research due to its non-psychotropic properties. Research supports its…”
Get full text

Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800 by Massey, Andrew J, Schoepfer, Joseph, Brough, Paul A, Brueggen, Josef, Chène, Patrick, Drysdale, Martin J, Pfaar, Ulrike, Radimerski, Thomas, Ruetz, Stephan, Schweitzer, Alain, Wood, Mike, Garcia-Echeverria, Carlos, Jensen, Michael Rugaard

“…Heat shock protein 90 (Hsp90) is a ubiquitously expressed molecular chaperone with ATPase activity involved in the conformational maturation and stability of…”
Get full text

Structure-based Drug Design Targeting an Inactive RNA Conformation: Exploiting the Flexibility of HIV-1 TAR RNA by Murchie, Alastair I.H., Davis, Ben, Isel, Catherine, Afshar, Mohammad, Drysdale, Martin J., Bower, Justin, Potter, Andrew J., Starkey, Ian D., Swarbrick, Terry M., Mirza, Shabana, Prescott, Catherine D., Vaglio, Philippe, Aboul-ela, Fareed, Karn, Jonathan

“…The targeting of RNA for the design of novel anti-viral compounds represents an area of vast potential. We have used NMR and computational methods to model the…”
Get full text

4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer by Brough, Paul A, Aherne, Wynne, Barril, Xavier, Borgognoni, Jenifer, Boxall, Kathy, Cansfield, Julie E, Cheung, Kwai-Ming J, Collins, Ian, Davies, Nicholas G. M, Drysdale, Martin J, Dymock, Brian, Eccles, Suzanne A, Finch, Harry, Fink, Alexandra, Hayes, Angela, Howes, Robert, Hubbard, Roderick E, James, Karen, Jordan, Allan M, Lockie, Andrea, Martins, Vanessa, Massey, Andrew, Matthews, Thomas P, McDonald, Edward, Northfield, Christopher J, Pearl, Laurence H, Prodromou, Chrisostomos, Ray, Stuart, Raynaud, Florence I, Roughley, Stephen D, Sharp, Swee Y, Surgenor, Allan, Walmsley, D. Lee, Webb, Paul, Wood, Mike, Workman, Paul, Wright, Lisa

“…Inhibitors of the Hsp90 molecular chaperone are showing considerable promise as potential chemotherapeutic agents for cancer. Here, we describe the…”
Get full text

Differential effects of cannabis extracts and pure plant cannabinoids on hippocampal neurones and glia by Ryan, Duncan, Drysdale, Alison J., Pertwee, Roger G., Platt, Bettina

“…We have shown previously that the plant cannabinoid cannabidiol (CBD) elevates intracellular calcium levels in both cultured hippocampal neurones and glia…”
Get full text

Cannabinoids: mechanisms and therapeutic applications in the CNS by Drysdale, Alison J, Platt, Bettina

“…Cannabinoids comprise three classes of compounds, the active components of marijuana (Cannabis sativa), as well as endogenous and synthetic derivatives. To…”
Get more information

Challenges encountered in the diagnosis of tuberculous otitis media: case report and literature review by Dale, O T, Clarke, A R, Drysdale, A J

“…To report a rare case of tuberculous otitis media, and to highlight barriers to clinical and microbiological diagnosis. Case report and literature review…”
Get more information

Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2+ Levels by Ryan, Duncan, Drysdale, Alison J, Lafourcade, Carlos, Pertwee, Roger G, Platt, Bettina

“…Cannabinoids and the endocannabinoid system have attracted considerable interest for therapeutic applications. Nevertheless, the mechanism of action of one of…”
Get full text

Preclinical pharmacokinetics and metabolism of a novel diaryl pyrazole resorcinol series of heat shock protein 90 inhibitors by Smith, Nicola F, Hayes, Angela, James, Karen, Nutley, Bernard P, McDonald, Edward, Henley, Alan, Dymock, Brian, Drysdale, Martin J, Raynaud, Florence I, Workman, Paul

“…CCT018159 was recently identified as a novel inhibitor of heat shock protein (Hsp) 90, a promising target for cancer therapy. Pharmacokinetic and metabolic…”
Get full text

4-Amino derivatives of the Hsp90 inhibitor CCT018159 by Barril, Xavier, Beswick, Mandy C., Collier, Adam, Drysdale, Martin J., Dymock, Brian W., Fink, Alexandra, Grant, Kate, Howes, Robert, Jordan, Allan M., Massey, Andrew, Surgenor, Allan, Wayne, Joanne, Workman, Paul, Wright, Lisa

“…Novel piperazinyl, morpholino and piperidyl derivatives of the pyrazole-based Hsp90 inhibitor CCT018159 have been prepared and the observed SAR explained by…”
Get full text

A fluorescence polarization assay for inhibitors of Hsp90 by Howes, R., Barril, X., Dymock, B.W., Grant, K., Northfield, C.J., Robertson, A.G.S., Surgenor, A., Wayne, J., Wright, L., James, K., Matthews, T., Cheung, K.-M., McDonald, E., Workman, P., Drysdale, M.J.

“…Hsp90 encodes a ubiquitous molecular chaperone protein conserved among species which acts on multiple substrates, many of which are important cell-signaling…”
Get full text

Discovery of a First-in-Class Inhibitor of the PRMT5–Substrate Adaptor Interaction by McKinney, David C, McMillan, Brian J, Ranaghan, Matthew J, Moroco, Jamie A, Brousseau, Merissa, Mullin-Bernstein, Zachary, O’Keefe, Meghan, McCarren, Patrick, Mesleh, Michael F, Mulvaney, Kathleen M, Robinson, Foxy, Singh, Ritu, Bajrami, Besnik, Wagner, Florence F, Hilgraf, Robert, Drysdale, Martin J, Campbell, Arthur J, Skepner, Adam, Timm, David E, Porter, Dale, Kaushik, Virendar K, Sellers, William R, Ianari, Alessandra

“…PRMT5 and its substrate adaptor proteins (SAPs), pICln and Riok1, are synthetic lethal dependencies in MTAP-deleted cancer cells. SAPs share a conserved PRMT5…”
Get full text

Differential toxicity of novel aluminium compounds in hippocampal culture by Platt, Bettina, Drysdale, Alison J., Nday, Christiane, Roloff, Eva v. Linstow, Drever, Benjamin D., Salifoglou, Athanasios

“…The dependence of aluminium (Al) toxicity on its chemical form has been implicated in previous studies, but the complex chemistry of Al in solutions of…”
Get full text

The use of transient evoked otoacoustic emissions as a hearing screen following grommet insertion by Dale, O T, McCann, L J, Thio, D, Wells, S C, Drysdale, A J

“…This study aimed to evaluate the sensitivity of transient evoked otoacoustic emission testing as a screening tool for hearing loss in children, after grommet…”
Get more information

Novel Adenosine-Derived Inhibitors of 70 kDa Heat Shock Protein, Discovered Through Structure-Based Design by Williamson, Douglas S, Borgognoni, Jenifer, Clay, Alexandra, Daniels, Zoe, Dokurno, Pawel, Drysdale, Martin J, Foloppe, Nicolas, Francis, Geraint L, Graham, Christopher J, Howes, Rob, Macias, Alba T, Murray, James B, Parsons, Rachel, Shaw, Terry, Surgenor, Allan E, Terry, Lindsey, Wang, Yikang, Wood, Mike, Massey, Andrew J

“…The design and synthesis of novel adenosine-derived inhibitors of HSP70, guided by modeling and X-ray crystallographic structures of these compounds in complex…”
Get full text

Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer by Unbekandt, Mathieu, Belshaw, Simone, Bower, Justin, Clarke, Maeve, Cordes, Jacqueline, Crighton, Diane, Croft, Daniel R, Drysdale, Martin J, Garnett, Mathew J, Gill, Kathryn, Gray, Christopher, Greenhalgh, David A, Hall, James A M, Konczal, Jennifer, Lilla, Sergio, McArthur, Duncan, McConnell, Patricia, McDonald, Laura, McGarry, Lynn, McKinnon, Heather, McMenemy, Carol, Mezna, Mokdad, Morrice, Nicolas A, Munro, June, Naylor, Gregory, Rath, Nicola, Schüttelkopf, Alexander W, Sime, Mairi, Olson, Michael F

“…The myotonic dystrophy-related Cdc42-binding kinases MRCKα and MRCKβ contribute to the regulation of actin-myosin cytoskeleton organization and dynamics,…”
Get full text

NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models by Jensen, Michael Rugaard, Schoepfer, Joseph, Radimerski, Thomas, Massey, Andrew, Guy, Chantale T, Brueggen, Josef, Quadt, Cornelia, Buckler, Alan, Cozens, Robert, Drysdale, Martin J, Garcia-Echeverria, Carlos, Chène, Patrick

“…Heat shock protein 90 (HSP90) is a key component of a multichaperone complex involved in the post-translational folding of a large number of client proteins,…”
Get full text