Search Results - "Dryer, Stuart E."

ATP acting through P2Y receptors causes activation of podocyte TRPC6 channels: role of podocin and reactive oxygen species by Roshanravan, Hila, Dryer, Stuart E

“…Extracellular ATP may contribute to Ca(2+) signaling in podocytes during tubuloglomerular feedback (TGF) and possibly as a result of local tissue damage. TRPC6…”
Get more information

Insulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species by Kim, Eun Young, Anderson, Marc, Dryer, Stuart E

“…Insulin receptors in podocytes are essential for normal kidney function. Here, we show that insulin evokes a rapid increase in the surface expression of…”
Get more information

Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol by Anderson, Marc, Kim, Eun Young, Hagmann, Henning, Benzing, Thomas, Dryer, Stuart E

“…Gain-of-function mutations in the transient receptor potential (TRP) cation channel subfamily C member 6 (TRPC6) gene and mutations in the NPHS2 gene encoding…”
Get more information

The Effects of TRPC6 Knockout in Animal Models of Kidney Disease by Dryer, Stuart E, Kim, Eun Young

“…Diseases that induce a loss of renal function affect a substantial portion of the world’s population and can range from a slight decline in the glomerular…”
Get full text

Angiotensin II Activation of TRPC6 Channels in Rat Podocytes Requires Generation of Reactive Oxygen Species by Anderson, Marc, Roshanravan, Hila, Khine, Justin, Dryer, Stuart E.

“…Angiotensin II (AII) plays a major role in the progression of chronic kidney diseases. Podocytes are essential components of the ultrafiltration apparatus, and…”
Get full text

Mechanisms underlying modulation of podocyte TRPC6 channels by suPAR: Role of NADPH oxidases and Src family tyrosine kinases by Kim, Eun Young, Hassanzadeh Khayyat, Naghmeh, Dryer, Stuart E.

“…The soluble urokinase receptor (suPAR) has been implicated in the pathogenesis of chronic kidney diseases (CKD) and may function as a circulating “permeability…”
Get full text

Permeation and Rectification in Canonical Transient Receptor Potential-6 (TRPC6) Channels by Dryer, Stuart E, Kim, Eun Young

“…Transient receptor potential-6 channels are widely expressed cation channels that play a role in regulating Ca dynamics, especially during G protein-coupled…”
Get full text

Role of Formyl Peptide Receptors and β-Arrestin-1 in suPAR Signal Transduction in Mouse Podocytes: Interactions with αVβ3-Integrin by Kim, Eun Young, Dryer, Stuart E

“…The soluble urokinase plasminogen activator receptor (suPAR) has been implicated in a wide range of pathological conditions including primary nephrotic…”
Get full text

Effects of TRPC6 Inactivation on Glomerulosclerosis and Renal Fibrosis in Aging Rats by Kim, Eun Young, Dryer, Stuart E

“…Canonical transient receptor potential 6 (TRPC6) channels have been implicated in familial and acquired forms of focal and segmental glomerulosclerosis (FSGS)…”
Get full text

Effects of insulin and high glucose on mobilization of slo1 BKCa channels in podocytes by Kim, Eun Young, Dryer, Stuart E.

“…Podocytes are dynamic polarized cells that lie on the surface of glomerular capillaries and comprise an essential component of the glomerular filitration…”
Get full text

TRPC6 Inactivation Reduces Albuminuria Induced by Protein Overload in Sprague Dawley Rats by Kim, Eun Young, Dryer, Stuart E

“…Canonical transient receptor potential-6 ( ) channels have been implicated in familial and acquired forms of focal and segmental glomerulosclerosis (FSGS), and…”
Get full text

Canonical transient receptor potential channel (TRPC)3 and TRPC6 associate with large-conductance Ca2+-activated K+ (BKCa) channels: role in BKCa trafficking to the surface of cultured podocytes by Kim, Eun Young, Alvarez-Baron, Claudia P, Dryer, Stuart E

“…Large-conductance (BK(Ca) type) Ca(2+)-activated K(+) channels encoded by the Slo1 gene and various canonical transient receptor potential channels (TRPCs) are…”
Get more information

20-Hydroxyeicosatetraenoic Acid (20-HETE) Modulates Canonical Transient Receptor Potential-6 (TRPC6) Channels in Podocytes by Roshanravan, Hila, Kim, Eun Y, Dryer, Stuart E

“…The arachidonic acid metabolite 20-hydroxyeicosatetraenoic acid (20-HETE) regulates renal function, including changes in glomerular function evoked during…”
Get full text

TRPC6 inactivation does not affect loss of renal function in nephrotoxic serum glomerulonephritis in rats, but reduces severity of glomerular lesions by Kim, Eun Young, Shotorbani, Parisa Yazdizadeh, Dryer, Stuart E

“…Canonical transient receptor potential-6 (TRPC6) channels have been implicated in a variety of chronic kidney diseases including familial and acquired forms of…”
Get full text

TRPC6 inactivation does not protect against diabetic kidney disease in streptozotocin (STZ)‐treated Sprague‐Dawley rats by Hassanzadeh Khayyat, Naghmeh, Kim, Eun Young, Dryer, Stuart E.

“…Canonical transient receptor potential‐6 (TRPC6) channels have been implicated in the progression of several forms of kidney disease (1). While there is strong…”
Get full text

Circadian Clocks in Antennal Neurons Are Necessary and Sufficient for Olfaction Rhythms in Drosophila by Tanoue, Shintaro, Krishnan, Parthasarathy, Krishnan, Balaji, Dryer, Stuart E, Hardin, Paul E

“…Background: The Drosophila circadian clock is controlled by interlocked transcriptional feedback loops that operate in many neuronal and nonneuronal tissues…”
Get full text

Ion channels and channelopathies in glomeruli by Staruschenko, Alexander, Ma, Rong, Palygin, Oleg, Dryer, Stuart E

“…An essential step in renal function entails the formation of an ultrafiltrate that is delivered to the renal tubules for subsequent processing. This process,…”
Get full text

Glutamate receptors in the kidney by Dryer, Stuart E

“…l-Glutamate (l-Glu) plays an essential role in the central nervous system (CNS) as an excitatory neurotransmitter, and exerts its effects by acting on a large…”
Get full text

Pleiotropic signaling evoked by tumor necrosis factor in podocytes by Abkhezr, Mousa, Kim, Eun Young, Roshanravan, Hila, Nikolos, Fotis, Thomas, Christoforos, Hagmann, Henning, Benzing, Thomas, Dryer, Stuart E

“…TNF has been implicated in glomerular diseases, but its actions on podocytes are not well understood. Endogenous TNF expression is markedly increased in mouse…”
Get more information

TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology by Dryer, Stuart E, Reiser, Jochen

“…Loss or dysfunction of podocytes is a major cause of glomerular kidney disease. Several genetic forms of glomerular disease are caused by mutations in genes…”
Get more information